Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19
We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. All study assessments and exercise sessions were conducted remotely (decentralized) in patient’s homes. Patients recei...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529385/full |
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| author | Jessica M. Scott Jessica M. Scott Zhuyu Qiu Zhuyu Qiu Jahan Rahman Chaya S. Moskowitz Meghan G. Michalski Sarah Lehman Catherine P. Lee Jenna Harrison Anthony F. Yu Anthony F. Yu Amira Marouf Amira Marouf Santosha Vardhana Santosha Vardhana Paul C. Boutros Paul C. Boutros Paul C. Boutros Paul C. Boutros Lee W. Jones Lee W. Jones |
| author_facet | Jessica M. Scott Jessica M. Scott Zhuyu Qiu Zhuyu Qiu Jahan Rahman Chaya S. Moskowitz Meghan G. Michalski Sarah Lehman Catherine P. Lee Jenna Harrison Anthony F. Yu Anthony F. Yu Amira Marouf Amira Marouf Santosha Vardhana Santosha Vardhana Paul C. Boutros Paul C. Boutros Paul C. Boutros Paul C. Boutros Lee W. Jones Lee W. Jones |
| author_sort | Jessica M. Scott |
| collection | DOAJ |
| description | We assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. All study assessments and exercise sessions were conducted remotely (decentralized) in patient’s homes. Patients received five escalated doses of aerobic exercise therapy (range, 90 to 375 minutes per week) following a tolerability-based adapted schedule over 30 consecutive weeks. Exercise therapy was safe (i.e., no serious adverse events), tolerable (i.e., all exercise therapy doses were completed, with an overall average relative exercise dose intensity of 89%), and associated with improvements in patient physiology (e.g., exercise capacity) and patient-reported outcomes (e.g., quality of life). Correlative proteomic and single-cell immune sequencing of peripheral blood samples revealed marked alterations in protein and immune phenotypes implicated in post COVID-19 condition. (ClinicalTrials.gov number, NCT04824443). |
| format | Article |
| id | doaj-art-00586fd7945e4fd58a281b8fa49bd4d8 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-00586fd7945e4fd58a281b8fa49bd4d82025-08-20T03:03:06ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15293851529385Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19Jessica M. Scott0Jessica M. Scott1Zhuyu Qiu2Zhuyu Qiu3Jahan Rahman4Chaya S. Moskowitz5Meghan G. Michalski6Sarah Lehman7Catherine P. Lee8Jenna Harrison9Anthony F. Yu10Anthony F. Yu11Amira Marouf12Amira Marouf13Santosha Vardhana14Santosha Vardhana15Paul C. Boutros16Paul C. Boutros17Paul C. Boutros18Paul C. Boutros19Lee W. Jones20Lee W. Jones21Department of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Weill Cornell Medical College, New York, NY, United StatesJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, United StatesHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Weill Cornell Medical College, New York, NY, United StatesHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, United StatesJonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Urology, University of California, Los Angeles, CA, United StatesInstitute for Precision Health, University of California, Los Angeles, CA, United StatesDepartment of Medicine, Memorial Sloan Kettering Cancer Center (MSK), New York, NY, United StatesDepartment of Medicine, Weill Cornell Medical College, New York, NY, United StatesWe assessed the safety, tolerability, and effects of exercise therapy in three patients with cancer and hospitalization for SARS-CoV-2 infection in an early-phase prospective trial. All study assessments and exercise sessions were conducted remotely (decentralized) in patient’s homes. Patients received five escalated doses of aerobic exercise therapy (range, 90 to 375 minutes per week) following a tolerability-based adapted schedule over 30 consecutive weeks. Exercise therapy was safe (i.e., no serious adverse events), tolerable (i.e., all exercise therapy doses were completed, with an overall average relative exercise dose intensity of 89%), and associated with improvements in patient physiology (e.g., exercise capacity) and patient-reported outcomes (e.g., quality of life). Correlative proteomic and single-cell immune sequencing of peripheral blood samples revealed marked alterations in protein and immune phenotypes implicated in post COVID-19 condition. (ClinicalTrials.gov number, NCT04824443).https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529385/fullexerciseimmune phenotypelong covidcancerdecentralized |
| spellingShingle | Jessica M. Scott Jessica M. Scott Zhuyu Qiu Zhuyu Qiu Jahan Rahman Chaya S. Moskowitz Meghan G. Michalski Sarah Lehman Catherine P. Lee Jenna Harrison Anthony F. Yu Anthony F. Yu Amira Marouf Amira Marouf Santosha Vardhana Santosha Vardhana Paul C. Boutros Paul C. Boutros Paul C. Boutros Paul C. Boutros Lee W. Jones Lee W. Jones Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 Frontiers in Immunology exercise immune phenotype long covid cancer decentralized |
| title | Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 |
| title_full | Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 |
| title_fullStr | Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 |
| title_full_unstemmed | Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 |
| title_short | Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 |
| title_sort | case report decentralized trial of tolerability adapted exercise therapy after severe covid 19 |
| topic | exercise immune phenotype long covid cancer decentralized |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1529385/full |
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