The mechanism of Ningxin-Tongyu-Zishen formula regulating probdnf/mbdnf balance through PAI-1/tPA signaling pathway in the treatment of premature ovarian insufficiency

The mechanism of Ningxin-Tongyu-Zishen formula regulating probdnf/mbdnf balance through PAI-1/tPA signaling pathway in the treatment of premature ovarian insufficiency

Abstract Background Premature ovarian insufficiency (POI) is a refractory gynecological endocrine disorder. Ningxin-Tongyu-Zishen formula (NTZF), developed based on the ‘simultaneous heart-kidney regulation’ principle, exhibits therapeutic efficacy in treating POI, potentially through regulating pro...

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Bibliographic Details
Main Authors: Jiawen Ma, Chaofan Zhu, Lifang Xie, Shuaiqi An, Zaiyang Zhang, Keying Wang, Yizhou Zhang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Ovarian Research
Subjects:
Premature ovarian insufficiency
Ningxin-Tongyu-Zishen formula
ProBDNF
mBDNF
PAI-1
tPA
Online Access:https://doi.org/10.1186/s13048-025-01769-1
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