Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study
Nicotine consumption is known to be a risk factor for cardiovascular disease. β-Caryophyllene (BCP), a sesquiterpene with anti-inflammatory properties, was investigated in a randomized, double-blind, placebo-controlled trial to see if smoking cigarettes with BCP-containing capsules could improve aor...
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| Format: | Article |
| Language: | English |
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Sciendo
2025-07-01
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| Series: | Contributions to Tobacco and Nicotine Research |
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| Online Access: | https://doi.org/10.2478/cttr-2025-0011 |
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| author | Yamada Kazuya Matahira Yoshiharu Takuwa Nagisa Yoshioka Yuri Matsumura Shin-ichi Higashihara Mayo Zaima Nobuhiro Unno Naoki |
| author_facet | Yamada Kazuya Matahira Yoshiharu Takuwa Nagisa Yoshioka Yuri Matsumura Shin-ichi Higashihara Mayo Zaima Nobuhiro Unno Naoki |
| author_sort | Yamada Kazuya |
| collection | DOAJ |
| description | Nicotine consumption is known to be a risk factor for cardiovascular disease. β-Caryophyllene (BCP), a sesquiterpene with anti-inflammatory properties, was investigated in a randomized, double-blind, placebo-controlled trial to see if smoking cigarettes with BCP-containing capsules could improve aortic stiffness. In this study, 84 adult smokers were randomly assigned to either a BCP group or a placebo group. They smoked capsule-loaded cigarettes for 12 weeks, and various health parameters were measured every 4 weeks. The primary focus was on changes in brachial-ankle pulse wave velocity (baPWV), which measures arterial stiffness. The results showed that blood BCP levels increased only in the BCP group, while nicotine levels rose in both groups. For participants with a high baseline baPWV (≥ 1,400 cm/s), significant reductions in baPWV were observed in the BCP group at weeks 4 and 8. Additionally, baPWV at week 4 was significantly lower in the BCP group compared to the placebo group. No adverse effects were reported. In conclusion, smoking BCP-containing cigarettes improved arterial stiffness in participants with high baseline baPWV without causing any adverse effects. |
| format | Article |
| id | doaj-art-004a07abe93e4d8da8bc1676084c2bec |
| institution | DOAJ |
| issn | 2719-9509 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Contributions to Tobacco and Nicotine Research |
| spelling | doaj-art-004a07abe93e4d8da8bc1676084c2bec2025-08-20T03:08:35ZengSciendoContributions to Tobacco and Nicotine Research2719-95092025-07-0134310711610.2478/cttr-2025-0011Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled StudyYamada Kazuya0Matahira Yoshiharu1Takuwa Nagisa2Yoshioka Yuri3Matsumura Shin-ichi4Higashihara Mayo5Zaima Nobuhiro6Unno Naoki7Sunsho Pharmaceutical Co., Ltd., 1468 Atsuhara, Fuji City, Shizuoka 419-0201, JapanSunsho Pharmaceutical Co., Ltd., 1468 Atsuhara, Fuji City, Shizuoka 419-0201, JapanINABATA KORYO, Co., Ltd., 3-5-20 Tagawa, Yodogawa-ku, Osaka City, Osaka 532-0027, JapanINABATA KORYO, Co., Ltd., 3-5-20 Tagawa, Yodogawa-ku, Osaka City, Osaka 532-0027, JapanINABATA KORYO, Co., Ltd., 3-5-20 Tagawa, Yodogawa-ku, Osaka City, Osaka 532-0027, JapanDepartment of Applied Biological Chemistry, Kindai University, 3327-204 Nakamachi, Nara City, Nara 631-8505, JapanDepartment of Applied Biological Chemistry, Kindai University, 3327-204 Nakamachi, Nara City, Nara 631-8505, JapanDivision of Vascular Surgery, Hamamatsu Medical Center, 328, Tomitsukacho, Chuo-ku, Hamamatsu City, Shizuoka, 432-8580, JapanNicotine consumption is known to be a risk factor for cardiovascular disease. β-Caryophyllene (BCP), a sesquiterpene with anti-inflammatory properties, was investigated in a randomized, double-blind, placebo-controlled trial to see if smoking cigarettes with BCP-containing capsules could improve aortic stiffness. In this study, 84 adult smokers were randomly assigned to either a BCP group or a placebo group. They smoked capsule-loaded cigarettes for 12 weeks, and various health parameters were measured every 4 weeks. The primary focus was on changes in brachial-ankle pulse wave velocity (baPWV), which measures arterial stiffness. The results showed that blood BCP levels increased only in the BCP group, while nicotine levels rose in both groups. For participants with a high baseline baPWV (≥ 1,400 cm/s), significant reductions in baPWV were observed in the BCP group at weeks 4 and 8. Additionally, baPWV at week 4 was significantly lower in the BCP group compared to the placebo group. No adverse effects were reported. In conclusion, smoking BCP-containing cigarettes improved arterial stiffness in participants with high baseline baPWV without causing any adverse effects.https://doi.org/10.2478/cttr-2025-0011smoking/harm reductiontobacco-related diseaseβ-caryophyllenebrachial-ankle pulse wave velocitycardiovascular disease |
| spellingShingle | Yamada Kazuya Matahira Yoshiharu Takuwa Nagisa Yoshioka Yuri Matsumura Shin-ichi Higashihara Mayo Zaima Nobuhiro Unno Naoki Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study Contributions to Tobacco and Nicotine Research smoking/harm reduction tobacco-related disease β-caryophyllene brachial-ankle pulse wave velocity cardiovascular disease |
| title | Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_full | Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_fullStr | Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_full_unstemmed | Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_short | Evidence of Improvements to Arterial Stiffness Among Regular Users of Combustible Cigarettes – Effect of Inhalation of β-Caryophyllene: A Randomized, Double-Blind, Placebo-Controlled Study |
| title_sort | evidence of improvements to arterial stiffness among regular users of combustible cigarettes effect of inhalation of β caryophyllene a randomized double blind placebo controlled study |
| topic | smoking/harm reduction tobacco-related disease β-caryophyllene brachial-ankle pulse wave velocity cardiovascular disease |
| url | https://doi.org/10.2478/cttr-2025-0011 |
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