Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers
Background and Objectives. This is a prospective nested cohort study conducted over a period of 3 years. 2644 women were recruited, out of which final analysis was done for 1884 women. Methods. Cervicovaginal and blood samples were collected for all recruited women. Out of these, 137 women who deliv...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2014/623269 |
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| author | Reva Tripathi Shakun Tyagi Nilanchali Singh Yedla Manikya Mala Chanchal Singh Preena Bhalla Siddhartha Ramji |
| author_facet | Reva Tripathi Shakun Tyagi Nilanchali Singh Yedla Manikya Mala Chanchal Singh Preena Bhalla Siddhartha Ramji |
| author_sort | Reva Tripathi |
| collection | DOAJ |
| description | Background and Objectives. This is a prospective nested cohort study conducted over a period of 3 years. 2644 women were recruited, out of which final analysis was done for 1884 women. Methods. Cervicovaginal and blood samples were collected for all recruited women. Out of these, 137 women who delivered before 35 weeks were treated as cases and equal number of matched controls were chosen. Analysis of samples for serum G-CSF, AFP, ferritin, and cervicovaginal interleukin-6 and IGFBP-1 was done. Results. Poor orodental hygiene, which can be a social marker, was significantly more common in women who delivered preterm (P=0.008). Serum alkaline phosphatase and serum ferritin were found to be significantly associated with preterm deliveries. The 90th percentile value of these parameters was considered as cut-off as there is no specific cut-off. Conclusions. Our study did not prove usefulness of any predictive marker. Serum ferritin and alkaline phosphatase were found to have correlation but their values are affected in many conditions and need to be elucidated with caution. Larger studies are needed for predicting preterm labour in asymptomatic women. |
| format | Article |
| id | doaj-art-004786a2a46b4f7596d5711bc262f619 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-004786a2a46b4f7596d5711bc262f6192025-08-20T03:55:23ZengWileyJournal of Pregnancy2090-27272090-27352014-01-01201410.1155/2014/623269623269Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical MarkersReva Tripathi0Shakun Tyagi1Nilanchali Singh2Yedla Manikya Mala3Chanchal Singh4Preena Bhalla5Siddhartha Ramji6Department of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi 110002, IndiaDepartment of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi 110002, IndiaDepartment of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi 110002, IndiaDepartment of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi 110002, IndiaDepartment of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi 110002, IndiaDepartment of Microbiology, Maulana Azad Medical College, New Delhi, IndiaDepartment of Paediatrics, Maulana Azad Medical College, New Delhi, IndiaBackground and Objectives. This is a prospective nested cohort study conducted over a period of 3 years. 2644 women were recruited, out of which final analysis was done for 1884 women. Methods. Cervicovaginal and blood samples were collected for all recruited women. Out of these, 137 women who delivered before 35 weeks were treated as cases and equal number of matched controls were chosen. Analysis of samples for serum G-CSF, AFP, ferritin, and cervicovaginal interleukin-6 and IGFBP-1 was done. Results. Poor orodental hygiene, which can be a social marker, was significantly more common in women who delivered preterm (P=0.008). Serum alkaline phosphatase and serum ferritin were found to be significantly associated with preterm deliveries. The 90th percentile value of these parameters was considered as cut-off as there is no specific cut-off. Conclusions. Our study did not prove usefulness of any predictive marker. Serum ferritin and alkaline phosphatase were found to have correlation but their values are affected in many conditions and need to be elucidated with caution. Larger studies are needed for predicting preterm labour in asymptomatic women.http://dx.doi.org/10.1155/2014/623269 |
| spellingShingle | Reva Tripathi Shakun Tyagi Nilanchali Singh Yedla Manikya Mala Chanchal Singh Preena Bhalla Siddhartha Ramji Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers Journal of Pregnancy |
| title | Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers |
| title_full | Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers |
| title_fullStr | Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers |
| title_full_unstemmed | Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers |
| title_short | Can Preterm Labour Be Predicted in Low Risk Pregnancies? Role of Clinical, Sonographic, and Biochemical Markers |
| title_sort | can preterm labour be predicted in low risk pregnancies role of clinical sonographic and biochemical markers |
| url | http://dx.doi.org/10.1155/2014/623269 |
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