Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates.

Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates.

The continued spread of highly pathogenic H5N1 influenza viruses among poultry and wild birds, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine. Inactivated subvirion or whole-virion H5N1 v...

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Main Authors: Shufang Fan, Yuwei Gao, Kyoko Shinya, Chris Kafai Li, Yanbing Li, Jianzhong Shi, Yongping Jiang, Yongbing Suo, Tiegang Tong, Gongxun Zhong, Jiasheng Song, Ying Zhang, Guobin Tian, Yuntao Guan, Xiao-Ning Xu, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000409&type=printable
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