Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus
Objectives. The aim was to investigate neutrophil gelatinase-associated lipocalin (NGAL) levels in the serum and term placentas and its potential role in gestational diabetes mellitus (GDM). Methods. A total of 49 GDM subjects and 39 age-matched women with normal pregnancies were recruited. We exami...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8760563 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568612396728320 |
|---|---|
| author | Xiaoqian Yin Yan Huo Li Liu Yixing Pan Suxin Liu Runfang Wang |
| author_facet | Xiaoqian Yin Yan Huo Li Liu Yixing Pan Suxin Liu Runfang Wang |
| author_sort | Xiaoqian Yin |
| collection | DOAJ |
| description | Objectives. The aim was to investigate neutrophil gelatinase-associated lipocalin (NGAL) levels in the serum and term placentas and its potential role in gestational diabetes mellitus (GDM). Methods. A total of 49 GDM subjects and 39 age-matched women with normal pregnancies were recruited. We examined serum concentrations of NGAL and tumor necrosis factor-α (TNF-α) in maternal blood and cord blood and their expression levels in the term placentas and umbilical cord. Results. Serum NGAL levels were significantly higher in GDM patients than in normal pregnant controls both in the maternal blood (4.80 ± 1.99 vs. 3.66 ± 1.13, P=0.001) and the cord blood (4.70 ± 2.08 vs. 3.85 ± 1.44, P=0.027). Moreover, serum NGAL levels exhibited a positive correlation with various parameters of insulin resistance. Maternal serum NGAL levels positively correlated with the NGAL levels found in the cord blood of the control (r = 0.399, P=0.012) and the GDM subjects (r = 0.349, P=0.014). Finally, the expression of NGAL protein levels in the placenta (1.22 ± 0.39 vs. 0.65 ± 0.23, P<0.001) and umbilical cord (0.65 ± 0.23 vs. 0.25 ± 0.10, P<0.001) were higher in GDM women than those noted in the control subjects. In the GDM group, maternal serum NGAL levels exhibited a positive correlation with placental NGAL mRNA and protein levels (r = 0.848, P=0.008; r = 0.636, P=0.011, respectively). Conclusions. NGAL may be an important adipokine involved in GDM and fetal development. The oversecretion of NGAL from the placenta may contribute to the elevated levels of serum NGAL in gestational diabetes mellitus. |
| format | Article |
| id | doaj-art-00417322cf51449c863b1f0a60db4d57 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-00417322cf51449c863b1f0a60db4d572025-02-03T00:58:41ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/87605638760563Serum Levels and Placental Expression of NGAL in Gestational Diabetes MellitusXiaoqian Yin0Yan Huo1Li Liu2Yixing Pan3Suxin Liu4Runfang Wang5Department of Obstetrics & Gynecology, Hebei General Hospital, Shijiazhuang 050051, ChinaDepartment of Obstetrics & Gynecology, Hebei General Hospital, Shijiazhuang 050051, ChinaDepartment of Obstetrics & Gynecology, Hebei General Hospital, Shijiazhuang 050051, ChinaDepartment of Obstetrics & Gynecology, Hebei General Hospital, Shijiazhuang 050051, ChinaDepartment of Obstetrics & Gynecology, Hebei General Hospital, Shijiazhuang 050051, ChinaDepartment of Obstetrics & Gynecology, Hebei General Hospital, Shijiazhuang 050051, ChinaObjectives. The aim was to investigate neutrophil gelatinase-associated lipocalin (NGAL) levels in the serum and term placentas and its potential role in gestational diabetes mellitus (GDM). Methods. A total of 49 GDM subjects and 39 age-matched women with normal pregnancies were recruited. We examined serum concentrations of NGAL and tumor necrosis factor-α (TNF-α) in maternal blood and cord blood and their expression levels in the term placentas and umbilical cord. Results. Serum NGAL levels were significantly higher in GDM patients than in normal pregnant controls both in the maternal blood (4.80 ± 1.99 vs. 3.66 ± 1.13, P=0.001) and the cord blood (4.70 ± 2.08 vs. 3.85 ± 1.44, P=0.027). Moreover, serum NGAL levels exhibited a positive correlation with various parameters of insulin resistance. Maternal serum NGAL levels positively correlated with the NGAL levels found in the cord blood of the control (r = 0.399, P=0.012) and the GDM subjects (r = 0.349, P=0.014). Finally, the expression of NGAL protein levels in the placenta (1.22 ± 0.39 vs. 0.65 ± 0.23, P<0.001) and umbilical cord (0.65 ± 0.23 vs. 0.25 ± 0.10, P<0.001) were higher in GDM women than those noted in the control subjects. In the GDM group, maternal serum NGAL levels exhibited a positive correlation with placental NGAL mRNA and protein levels (r = 0.848, P=0.008; r = 0.636, P=0.011, respectively). Conclusions. NGAL may be an important adipokine involved in GDM and fetal development. The oversecretion of NGAL from the placenta may contribute to the elevated levels of serum NGAL in gestational diabetes mellitus.http://dx.doi.org/10.1155/2020/8760563 |
| spellingShingle | Xiaoqian Yin Yan Huo Li Liu Yixing Pan Suxin Liu Runfang Wang Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus International Journal of Endocrinology |
| title | Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus |
| title_full | Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus |
| title_fullStr | Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus |
| title_full_unstemmed | Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus |
| title_short | Serum Levels and Placental Expression of NGAL in Gestational Diabetes Mellitus |
| title_sort | serum levels and placental expression of ngal in gestational diabetes mellitus |
| url | http://dx.doi.org/10.1155/2020/8760563 |
| work_keys_str_mv | AT xiaoqianyin serumlevelsandplacentalexpressionofngalingestationaldiabetesmellitus AT yanhuo serumlevelsandplacentalexpressionofngalingestationaldiabetesmellitus AT liliu serumlevelsandplacentalexpressionofngalingestationaldiabetesmellitus AT yixingpan serumlevelsandplacentalexpressionofngalingestationaldiabetesmellitus AT suxinliu serumlevelsandplacentalexpressionofngalingestationaldiabetesmellitus AT runfangwang serumlevelsandplacentalexpressionofngalingestationaldiabetesmellitus |