Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]
Background Dehydration secondary to diarrhoea is a major cause of hospitalization and mortality in children aged less than five years. Most diarrhoea cases in childhood are caused by rotavirus, and routine introduction of rotavirus vaccine is expected to reduce the incidence and severity of dehydrat...
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Wellcome
2025-01-01
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| author | Samuel Akech Lucas Malla Daisy Chelangat Reuben C. Langat |
| author_facet | Samuel Akech Lucas Malla Daisy Chelangat Reuben C. Langat |
| author_sort | Samuel Akech |
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| description | Background Dehydration secondary to diarrhoea is a major cause of hospitalization and mortality in children aged less than five years. Most diarrhoea cases in childhood are caused by rotavirus, and routine introduction of rotavirus vaccine is expected to reduce the incidence and severity of dehydration secondary to diarrhoea in vaccinated infants. Previously, studies have examined changes in admissions with stools positive for rotavirus but this study reports on all admissions with dehydration secondary to diarrhoea regardless of stool rotavirus results. We aimed to assess the changes in all-cause severe diarrhoea and dehydration (DAD) admissions following the vaccine’s introduction. Methods We examined changes in admissions of all clinical cases of DAD before and after introduction of routine vaccination with rotavirus vaccine in July 2014 in Kenya. We use data from 13 public hospitals currently involved in a clinical network, the Clinical Information Network (CIN). Routinely collected data for children aged 2-36 months were examined. We used a segmented mixed effects model to assess changes in the burden of diarrhoea and dehydration after introduction of rotavirus vaccine. For sensitivity analysis, we examined trends for non-febrile admissions (surgical or burns). Results There were 17,708 patients classified as having both diarrhoea and dehydration. Average monthly admissions due to DAD for each hospital before vaccine introduction (July 2014) was 35 (standard deviation: ±22) and 17 (standard deviation: ±12) after vaccine introduction. Segmented mixed effects regression model showed there was a 33% (95% CI, 30% to 38%) decrease in DAD admissions immediately after the vaccine was introduced to the Kenya immunization program in July 2014. There was no change in admissions due to non-febrile admissions pre-and post-vaccine introduction. Conclusion The rotavirus vaccine, after introduction into the Kenya routine immunization program resulted in reduction of all-cause admissions of diarrhoea and dehydration in children to public hospitals. |
| format | Article |
| id | doaj-art-003c813f674e40b6b8d22299a84089e4 |
| institution | Kabale University |
| issn | 2398-502X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wellcome |
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| series | Wellcome Open Research |
| spelling | doaj-art-003c813f674e40b6b8d22299a84089e42025-01-31T01:00:00ZengWellcomeWellcome Open Research2398-502X2025-01-01725455Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved]Samuel Akech0https://orcid.org/0000-0001-5126-1225Lucas Malla1Daisy Chelangat2https://orcid.org/0000-0002-8761-0332Reuben C. Langat3Health Services Unit, KEMRI-Centre of Geographic Medicine Research-Coast/ KEMRI-Wellcome Trust Research Programe, Nairobi, KenyaInfectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, London, WC1E7HT, UKHealth Services Unit, KEMRI-Centre of Geographic Medicine Research-Coast/ KEMRI-Wellcome Trust Research Programe, Nairobi, KenyaDepartment of Mathematics and Computer Science, University of Kabianga, Kericho, KenyaBackground Dehydration secondary to diarrhoea is a major cause of hospitalization and mortality in children aged less than five years. Most diarrhoea cases in childhood are caused by rotavirus, and routine introduction of rotavirus vaccine is expected to reduce the incidence and severity of dehydration secondary to diarrhoea in vaccinated infants. Previously, studies have examined changes in admissions with stools positive for rotavirus but this study reports on all admissions with dehydration secondary to diarrhoea regardless of stool rotavirus results. We aimed to assess the changes in all-cause severe diarrhoea and dehydration (DAD) admissions following the vaccine’s introduction. Methods We examined changes in admissions of all clinical cases of DAD before and after introduction of routine vaccination with rotavirus vaccine in July 2014 in Kenya. We use data from 13 public hospitals currently involved in a clinical network, the Clinical Information Network (CIN). Routinely collected data for children aged 2-36 months were examined. We used a segmented mixed effects model to assess changes in the burden of diarrhoea and dehydration after introduction of rotavirus vaccine. For sensitivity analysis, we examined trends for non-febrile admissions (surgical or burns). Results There were 17,708 patients classified as having both diarrhoea and dehydration. Average monthly admissions due to DAD for each hospital before vaccine introduction (July 2014) was 35 (standard deviation: ±22) and 17 (standard deviation: ±12) after vaccine introduction. Segmented mixed effects regression model showed there was a 33% (95% CI, 30% to 38%) decrease in DAD admissions immediately after the vaccine was introduced to the Kenya immunization program in July 2014. There was no change in admissions due to non-febrile admissions pre-and post-vaccine introduction. Conclusion The rotavirus vaccine, after introduction into the Kenya routine immunization program resulted in reduction of all-cause admissions of diarrhoea and dehydration in children to public hospitals.https://wellcomeopenresearch.org/articles/7-2/v2Diarrhea dehydration time series rotavirus vaccine clinical information networkeng |
| spellingShingle | Samuel Akech Lucas Malla Daisy Chelangat Reuben C. Langat Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] Wellcome Open Research Diarrhea dehydration time series rotavirus vaccine clinical information network eng |
| title | Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_full | Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_fullStr | Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_full_unstemmed | Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_short | Examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in Kenyan hospitals: A study using interrupted time series analysis. [version 2; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_sort | examining the impact of implementing routine rotavirus vaccination on the number of paediatric admissions due to diarrhoea and dehydration in kenyan hospitals a study using interrupted time series analysis version 2 peer review 1 approved 2 approved with reservations 1 not approved |
| topic | Diarrhea dehydration time series rotavirus vaccine clinical information network eng |
| url | https://wellcomeopenresearch.org/articles/7-2/v2 |
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