Age-related retinopathy in NRF2-deficient mice.

Age-related retinopathy in NRF2-deficient mice.

<h4>Background</h4>Cumulative oxidative damage is implicated in the pathogenesis of age-related macular degeneration (AMD). Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that plays key roles in retinal antioxidant and detoxification responses. The purposes...

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Main Authors: Zhenyang Zhao, Yan Chen, Jian Wang, Paul Sternberg, Michael L Freeman, Hans E Grossniklaus, Jiyang Cai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0019456&type=printable
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