Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilers
Tannic acid (TA), a polyphenolic compound derived from plants, exhibits anti-inflammatory, antibacterial, antiviral, and antioxidant biological activities. Salmonella, a prevalent foodborne pathogen, poses a significant threat to poultry, resulting in considerable economic losses for the animal husb...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579125002123 |
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| author | Aoao Wu Liu Xu Yinzhu Zhang Yuanyuan Zhu You Wu Jing Wu Lixin Wen Zhihang Yuan Ji Wang |
| author_facet | Aoao Wu Liu Xu Yinzhu Zhang Yuanyuan Zhu You Wu Jing Wu Lixin Wen Zhihang Yuan Ji Wang |
| author_sort | Aoao Wu |
| collection | DOAJ |
| description | Tannic acid (TA), a polyphenolic compound derived from plants, exhibits anti-inflammatory, antibacterial, antiviral, and antioxidant biological activities. Salmonella, a prevalent foodborne pathogen, poses a significant threat to poultry, resulting in considerable economic losses for the animal husbandry industry. In this study, we investigated the protective effects of TA against lung and intestinal injuries induced by a transient Salmonella infection in broilers. After a ten-day infection period, although Salmonella was not detected in the intestinal content of broilers, the infected broilers exhibited reduced body weight and compromised intestinal barrier function. Salmonella infection facilitated the growth of detrimental bacteria in the lungs and ileums, triggering an inflammatory response. TA inhibited the pathogen's colonization in the lungs and reduced serum levels of lipopolysaccharide (LPS) as well as lung levels of myeloperoxidase (MPO). Moreover, TA down-regulated the expression of pro-inflammatory cytokines and hindered the polarization of M1 macrophages in the lungs.In summary, TA mitigates Salmonella-induced lung inflammation and immune imbalance by its anti-inflammatory, antioxidant and antibacterial properties in broilers. |
| format | Article |
| id | doaj-art-00390f70a6b447f699ae61ea8c4ff441 |
| institution | DOAJ |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj-art-00390f70a6b447f699ae61ea8c4ff4412025-08-20T02:59:15ZengElsevierPoultry Science0032-57912025-04-01104410497310.1016/j.psj.2025.104973Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilersAoao Wu0Liu Xu1Yinzhu Zhang2Yuanyuan Zhu3You Wu4Jing Wu5Lixin Wen6Zhihang Yuan7Ji Wang8Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR China; Changsha Luye Biotechnology Co., Ltd, Changsha 410100, PR ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR ChinaHunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR China; Corresponding authors: Hunan Agricultural University, Changsha 410128, PR China.Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, PR China; Changsha Luye Biotechnology Co., Ltd, Changsha 410100, PR China; Corresponding authors: Hunan Agricultural University, Changsha 410128, PR China.; Corresponding authors: Changsha Luye Biotechnology Co., Ltd, Changsha 410100, PR China.Tannic acid (TA), a polyphenolic compound derived from plants, exhibits anti-inflammatory, antibacterial, antiviral, and antioxidant biological activities. Salmonella, a prevalent foodborne pathogen, poses a significant threat to poultry, resulting in considerable economic losses for the animal husbandry industry. In this study, we investigated the protective effects of TA against lung and intestinal injuries induced by a transient Salmonella infection in broilers. After a ten-day infection period, although Salmonella was not detected in the intestinal content of broilers, the infected broilers exhibited reduced body weight and compromised intestinal barrier function. Salmonella infection facilitated the growth of detrimental bacteria in the lungs and ileums, triggering an inflammatory response. TA inhibited the pathogen's colonization in the lungs and reduced serum levels of lipopolysaccharide (LPS) as well as lung levels of myeloperoxidase (MPO). Moreover, TA down-regulated the expression of pro-inflammatory cytokines and hindered the polarization of M1 macrophages in the lungs.In summary, TA mitigates Salmonella-induced lung inflammation and immune imbalance by its anti-inflammatory, antioxidant and antibacterial properties in broilers.http://www.sciencedirect.com/science/article/pii/S0032579125002123Tannic acidSalmonellabroilergut-lung axisMacrophage polarization |
| spellingShingle | Aoao Wu Liu Xu Yinzhu Zhang Yuanyuan Zhu You Wu Jing Wu Lixin Wen Zhihang Yuan Ji Wang Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilers Poultry Science Tannic acid Salmonella broiler gut-lung axis Macrophage polarization |
| title | Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilers |
| title_full | Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilers |
| title_fullStr | Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilers |
| title_full_unstemmed | Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilers |
| title_short | Tannic acid mitigates salmonella-induced lung injury via gut-lung axis in broilers |
| title_sort | tannic acid mitigates salmonella induced lung injury via gut lung axis in broilers |
| topic | Tannic acid Salmonella broiler gut-lung axis Macrophage polarization |
| url | http://www.sciencedirect.com/science/article/pii/S0032579125002123 |
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