Role of IL-38 and Its Related Cytokines in Inflammation
Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the produ...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/807976 |
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| _version_ | 1849387069721280512 |
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| author | Xianli Yuan Xiao Peng Yan Li Mingcai Li |
| author_facet | Xianli Yuan Xiao Peng Yan Li Mingcai Li |
| author_sort | Xianli Yuan |
| collection | DOAJ |
| description | Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future. |
| format | Article |
| id | doaj-art-003756e4be154c399384bcee8daf052b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-003756e4be154c399384bcee8daf052b2025-08-20T03:55:23ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/807976807976Role of IL-38 and Its Related Cytokines in InflammationXianli Yuan0Xiao Peng1Yan Li2Mingcai Li3Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, ChinaZhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, ChinaZhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, ChinaZhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, ChinaInterleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.http://dx.doi.org/10.1155/2015/807976 |
| spellingShingle | Xianli Yuan Xiao Peng Yan Li Mingcai Li Role of IL-38 and Its Related Cytokines in Inflammation Mediators of Inflammation |
| title | Role of IL-38 and Its Related Cytokines in Inflammation |
| title_full | Role of IL-38 and Its Related Cytokines in Inflammation |
| title_fullStr | Role of IL-38 and Its Related Cytokines in Inflammation |
| title_full_unstemmed | Role of IL-38 and Its Related Cytokines in Inflammation |
| title_short | Role of IL-38 and Its Related Cytokines in Inflammation |
| title_sort | role of il 38 and its related cytokines in inflammation |
| url | http://dx.doi.org/10.1155/2015/807976 |
| work_keys_str_mv | AT xianliyuan roleofil38anditsrelatedcytokinesininflammation AT xiaopeng roleofil38anditsrelatedcytokinesininflammation AT yanli roleofil38anditsrelatedcytokinesininflammation AT mingcaili roleofil38anditsrelatedcytokinesininflammation |