Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis
BackgroundDiabetic nephropathy (DN) represents one of the most prevalent microvascular complications of type 2 diabetes mellitus (T2DM). The pathogenesis of DN is significantly influenced by the inflammatory response. Thus, the current meta-analysis aimed to assess the diagnostic accuracy of neutrop...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1564170/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850098090657185792 |
|---|---|
| author | Yan Wang Xiaohua Liu Zhenwen Xiao |
| author_facet | Yan Wang Xiaohua Liu Zhenwen Xiao |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | BackgroundDiabetic nephropathy (DN) represents one of the most prevalent microvascular complications of type 2 diabetes mellitus (T2DM). The pathogenesis of DN is significantly influenced by the inflammatory response. Thus, the current meta-analysis aimed to assess the diagnostic accuracy of neutrophil-to-lymphocyte ratio (NLR) in early DN and DN.MethodsCochrane, Pubmed, Embase, and Web of Science were retrieved from database establishment to August 31, 2024. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was utilized to assess the quality of included studies. This meta-analysis was carried out via Stata16.0 and Revman 5.3 software.ResultsFinally, this meta-analysis incorporated 18 studies, of which 5 were early DN studies, involving 232 patients with early DN, and 13 were DN studies, involving 4,818 patients with DN. The results indicated that the diagnostic sensitivity of NLR for early DN was 0.83 [95% CI: 0.60-0.94], the specificity was 0.76 [95% CI: 0.61-0.86], and the area under the receiver operating characteristic curve (AUROC) was 0.85 [95% CI: 0.81-0.88]. The diagnostic sensitivity of NLR for DN was 0.73 [95% CI: 0.67-0.79], the specificity was 0.70 [95% CI: 0.59-0.79], and the AUROC was 0.78 [95% CI: 0.74-0.81].ConclusionsNLR exhibited moderate performance in diagnosing both early DN and DN, and its diagnostic accuracy was higher in early DN than in DN. Due to the limitations of existing studies, further studies are required to verify the findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024591926. |
| format | Article |
| id | doaj-art-002f648511fa41b48c92f7e7968a6d74 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-002f648511fa41b48c92f7e7968a6d742025-08-20T02:40:48ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.15641701564170Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysisYan Wang0Xiaohua Liu1Zhenwen Xiao2Clinical Laboratory Department, Jinan Third People’s Hospital, Jinan, Shandong, ChinaClinical Laboratory Department, Jinan Third People’s Hospital, Jinan, Shandong, ChinaDepartment of Nephrology, Jinan Third People’s Hospital, Jinan, Shandong, ChinaBackgroundDiabetic nephropathy (DN) represents one of the most prevalent microvascular complications of type 2 diabetes mellitus (T2DM). The pathogenesis of DN is significantly influenced by the inflammatory response. Thus, the current meta-analysis aimed to assess the diagnostic accuracy of neutrophil-to-lymphocyte ratio (NLR) in early DN and DN.MethodsCochrane, Pubmed, Embase, and Web of Science were retrieved from database establishment to August 31, 2024. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was utilized to assess the quality of included studies. This meta-analysis was carried out via Stata16.0 and Revman 5.3 software.ResultsFinally, this meta-analysis incorporated 18 studies, of which 5 were early DN studies, involving 232 patients with early DN, and 13 were DN studies, involving 4,818 patients with DN. The results indicated that the diagnostic sensitivity of NLR for early DN was 0.83 [95% CI: 0.60-0.94], the specificity was 0.76 [95% CI: 0.61-0.86], and the area under the receiver operating characteristic curve (AUROC) was 0.85 [95% CI: 0.81-0.88]. The diagnostic sensitivity of NLR for DN was 0.73 [95% CI: 0.67-0.79], the specificity was 0.70 [95% CI: 0.59-0.79], and the AUROC was 0.78 [95% CI: 0.74-0.81].ConclusionsNLR exhibited moderate performance in diagnosing both early DN and DN, and its diagnostic accuracy was higher in early DN than in DN. Due to the limitations of existing studies, further studies are required to verify the findings.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024591926.https://www.frontiersin.org/articles/10.3389/fendo.2025.1564170/fulldiabetic nephropathyearly diabetic nephropathyneutrophils/lymphocytesmeta-analysisneutrophil-lymphocyte ratio |
| spellingShingle | Yan Wang Xiaohua Liu Zhenwen Xiao Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis Frontiers in Endocrinology diabetic nephropathy early diabetic nephropathy neutrophils/lymphocytes meta-analysis neutrophil-lymphocyte ratio |
| title | Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis |
| title_full | Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis |
| title_fullStr | Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis |
| title_full_unstemmed | Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis |
| title_short | Diagnostic accuracy of neutrophil-to-lymphocyte ratio in type 2 diabetic nephropathy: a meta-analysis |
| title_sort | diagnostic accuracy of neutrophil to lymphocyte ratio in type 2 diabetic nephropathy a meta analysis |
| topic | diabetic nephropathy early diabetic nephropathy neutrophils/lymphocytes meta-analysis neutrophil-lymphocyte ratio |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1564170/full |
| work_keys_str_mv | AT yanwang diagnosticaccuracyofneutrophiltolymphocyteratiointype2diabeticnephropathyametaanalysis AT xiaohualiu diagnosticaccuracyofneutrophiltolymphocyteratiointype2diabeticnephropathyametaanalysis AT zhenwenxiao diagnosticaccuracyofneutrophiltolymphocyteratiointype2diabeticnephropathyametaanalysis |