Serotonin 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice

Serotonin 5-HT2A and 5-HT2C receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice

IntroductionStudies suggest that serotonin (5-HT) plays an important role in alcohol use disorder (AUD). While several receptor subtypes modulate the role of 5-HT in AUD, evidence suggests that 5-HT2A and 5-HT2C receptors may be directly involved in alcohol drinking due to their interaction with the...

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Main Authors: Sandy C. Simões, Livia N. Amorim, Yasmim A. Serra, Camila S. Abreu, Maria Clara E. Santana, João P. C. Leite, Carla M. Kaneto, Roberta C. A. Costa, Kaio R. Ferreira, Isabelle C. S. de Oliveira, Alexandre J. Oliveira-Lima, Agnieszka Sulima, Kenner C. Rice, Eduardo A. V. Marinho, Lais F. Berro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Neuroscience
Subjects:
alcohol
serotonin
two-bottle choice
mice
5-HT2A
5-HT2C
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1639344/full
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