Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution
Toscana virus (TOSV), a member of the <i>Phlebovirus</i> genus transmitted by sandflies, is acknowledged for its capacity to cause neurological infections and is widely distributed across Mediterranean countries. The potential geographic distribution and risk to the human population rema...
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2024-12-01
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| author | Xue-Geng Hong Mei-Qi Zhang Fang Tang Si-Hui Song Jia-Yi Wang Zhen-Yu Hu Li-Ming Liu Xiao-Ai Zhang Yi Sun Li-Qun Fang Wei Liu |
| author_facet | Xue-Geng Hong Mei-Qi Zhang Fang Tang Si-Hui Song Jia-Yi Wang Zhen-Yu Hu Li-Ming Liu Xiao-Ai Zhang Yi Sun Li-Qun Fang Wei Liu |
| author_sort | Xue-Geng Hong |
| collection | DOAJ |
| description | Toscana virus (TOSV), a member of the <i>Phlebovirus</i> genus transmitted by sandflies, is acknowledged for its capacity to cause neurological infections and is widely distributed across Mediterranean countries. The potential geographic distribution and risk to the human population remained obscure due to its neglected nature. We searched PubMed and Web of Science for articles published between 1 January 1971 and 30 June 2023 to extract data on TOSV detection in vectors, vertebrates and humans, clinical information of human patients, as well as the occurrence of two identified sandfly vectors for TOSV. We further predicted the global distribution of the two sandfly vectors, based on which the global risk of TOSV was projected, after incorporating the environmental, ecoclimatic, biological, and socioeconomic factors. A total of 1342 unique studies were retrieved, among which 389 met the selection criteria and were included for data extraction. TOSV infections were documented in 10 sandfly species and 14 species of vertebrates, as well as causing a total of 7571 human infections. The occurrence probabilities of two sandfly vectors have demonstrated the greatest contributions to the potential distribution of TOSV infection risk. This study provides a comprehensive overview of global TOSV distribution and potential risk zones. Future surveillance and intervention programs should prioritize high-risk areas based on updated quantitative analyses. |
| format | Article |
| id | doaj-art-00268649c4b34fd1b96da44fc06d74e0 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-00268649c4b34fd1b96da44fc06d74e02025-01-24T13:52:15ZengMDPI AGViruses1999-49152024-12-011711510.3390/v17010015Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk DistributionXue-Geng Hong0Mei-Qi Zhang1Fang Tang2Si-Hui Song3Jia-Yi Wang4Zhen-Yu Hu5Li-Ming Liu6Xiao-Ai Zhang7Yi Sun8Li-Qun Fang9Wei Liu10State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaInstitute of Medical Prevention and Control of Public Health Emergencies, Characteristic Medical Center of the Chinese People’s Armed Police Force, Beijing 102613, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaSchool of Public Health, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, ChinaCollege of Animal Science and Technology, Jilin Agricultural Science and Technology University, Jilin 132101, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, ChinaToscana virus (TOSV), a member of the <i>Phlebovirus</i> genus transmitted by sandflies, is acknowledged for its capacity to cause neurological infections and is widely distributed across Mediterranean countries. The potential geographic distribution and risk to the human population remained obscure due to its neglected nature. We searched PubMed and Web of Science for articles published between 1 January 1971 and 30 June 2023 to extract data on TOSV detection in vectors, vertebrates and humans, clinical information of human patients, as well as the occurrence of two identified sandfly vectors for TOSV. We further predicted the global distribution of the two sandfly vectors, based on which the global risk of TOSV was projected, after incorporating the environmental, ecoclimatic, biological, and socioeconomic factors. A total of 1342 unique studies were retrieved, among which 389 met the selection criteria and were included for data extraction. TOSV infections were documented in 10 sandfly species and 14 species of vertebrates, as well as causing a total of 7571 human infections. The occurrence probabilities of two sandfly vectors have demonstrated the greatest contributions to the potential distribution of TOSV infection risk. This study provides a comprehensive overview of global TOSV distribution and potential risk zones. Future surveillance and intervention programs should prioritize high-risk areas based on updated quantitative analyses.https://www.mdpi.com/1999-4915/17/1/15Toscana virussandfly<i>Phlebovirus</i>machine learning |
| spellingShingle | Xue-Geng Hong Mei-Qi Zhang Fang Tang Si-Hui Song Jia-Yi Wang Zhen-Yu Hu Li-Ming Liu Xiao-Ai Zhang Yi Sun Li-Qun Fang Wei Liu Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution Viruses Toscana virus sandfly <i>Phlebovirus</i> machine learning |
| title | Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution |
| title_full | Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution |
| title_fullStr | Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution |
| title_full_unstemmed | Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution |
| title_short | Epidemiology and Ecology of Toscana Virus Infection and Its Global Risk Distribution |
| title_sort | epidemiology and ecology of toscana virus infection and its global risk distribution |
| topic | Toscana virus sandfly <i>Phlebovirus</i> machine learning |
| url | https://www.mdpi.com/1999-4915/17/1/15 |
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