A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma
Abstract Background Mean platelet volume (MPV), as a marker of platelet activity, has been shown to be an efficient prognostic biomarker in several types of cancer. Using MPV, this study aimed to create and validate a prognostic nomogram to the overall survival in esophageal squamous cell carcinoma...
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Wiley
2023-10-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6551 |
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| author | Qiao He Zhenglian Luo Haiming Zou Bo Ye Lichun Wu Yao Deng Mu Yang Dongsheng Wang Qifeng Wang Kaijiong Zhang |
| author_facet | Qiao He Zhenglian Luo Haiming Zou Bo Ye Lichun Wu Yao Deng Mu Yang Dongsheng Wang Qifeng Wang Kaijiong Zhang |
| author_sort | Qiao He |
| collection | DOAJ |
| description | Abstract Background Mean platelet volume (MPV), as a marker of platelet activity, has been shown to be an efficient prognostic biomarker in several types of cancer. Using MPV, this study aimed to create and validate a prognostic nomogram to the overall survival in esophageal squamous cell carcinoma (ESCC) patients. Methods The nomogram was constructed and tested using data from a retrospective study of 1893 patients who were randomly assigned to the training and testing cohorts with a 7:3 randomization. In order to screen out the optimal predictors for overall survival (OS), we conducted the LASSO‐cox regression, univariate, and multivariate cox regression analyses. Subsequently, the predictive accuracy of the nomogram was validated in both the training and the testing cohorts. Finally, decision curve analysis (DCA) was used to confirm clinical validity. Results Age, MPV, nerve invasion, T stage, and N stage were found as independent prognostic variables for OS and were further developed into a nomogram. The nomogram's prediction accuracy for 1‐, 3‐, and 5‐year OS was 0.736, 0.749, 0.774, and 0.724, 0.719, 0.704 in the training and testing cohorts, respectively. Furthermore, DCA results indicated that nomograms outperformed the AJCC 8th and conventional T, N staging systems in both the training and testing cohorts. Conclusions The nomogram, in conjunction with MPV and standard clinicopathological markers, could improve the accuracy of prediction of OS in ESCC patients. |
| format | Article |
| id | doaj-art-002622d0997a41bb9a14cc2234293c82 |
| institution | OA Journals |
| issn | 2045-7634 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-002622d0997a41bb9a14cc2234293c822025-08-20T02:11:08ZengWileyCancer Medicine2045-76342023-10-011220202662027610.1002/cam4.6551A prognostic nomogram that includes MPV in esophageal squamous cell carcinomaQiao He0Zhenglian Luo1Haiming Zou2Bo Ye3Lichun Wu4Yao Deng5Mu Yang6Dongsheng Wang7Qifeng Wang8Kaijiong Zhang9Department of Clinical Laboratory Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu ChinaDepartment of Transfusion Medicine, West China Hospital Sichuan University Chengdu ChinaDepartment of Clinical Laboratory Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu ChinaDepartment of Clinical Laboratory Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu ChinaDepartment of Clinical Laboratory Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu ChinaDepartment of Clinical Laboratory Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu ChinaCentre for Translational Research in Cancer Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Chengdu ChinaDepartment of Clinical Laboratory Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China Chengdu ChinaDepartment of Radiation Oncology Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China Chengdu ChinaDepartment of Clinical Laboratory Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China Chengdu ChinaAbstract Background Mean platelet volume (MPV), as a marker of platelet activity, has been shown to be an efficient prognostic biomarker in several types of cancer. Using MPV, this study aimed to create and validate a prognostic nomogram to the overall survival in esophageal squamous cell carcinoma (ESCC) patients. Methods The nomogram was constructed and tested using data from a retrospective study of 1893 patients who were randomly assigned to the training and testing cohorts with a 7:3 randomization. In order to screen out the optimal predictors for overall survival (OS), we conducted the LASSO‐cox regression, univariate, and multivariate cox regression analyses. Subsequently, the predictive accuracy of the nomogram was validated in both the training and the testing cohorts. Finally, decision curve analysis (DCA) was used to confirm clinical validity. Results Age, MPV, nerve invasion, T stage, and N stage were found as independent prognostic variables for OS and were further developed into a nomogram. The nomogram's prediction accuracy for 1‐, 3‐, and 5‐year OS was 0.736, 0.749, 0.774, and 0.724, 0.719, 0.704 in the training and testing cohorts, respectively. Furthermore, DCA results indicated that nomograms outperformed the AJCC 8th and conventional T, N staging systems in both the training and testing cohorts. Conclusions The nomogram, in conjunction with MPV and standard clinicopathological markers, could improve the accuracy of prediction of OS in ESCC patients.https://doi.org/10.1002/cam4.6551clinicopathological indicatorsESCCMPVOSprognostic nomogram |
| spellingShingle | Qiao He Zhenglian Luo Haiming Zou Bo Ye Lichun Wu Yao Deng Mu Yang Dongsheng Wang Qifeng Wang Kaijiong Zhang A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma Cancer Medicine clinicopathological indicators ESCC MPV OS prognostic nomogram |
| title | A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma |
| title_full | A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma |
| title_fullStr | A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma |
| title_full_unstemmed | A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma |
| title_short | A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma |
| title_sort | prognostic nomogram that includes mpv in esophageal squamous cell carcinoma |
| topic | clinicopathological indicators ESCC MPV OS prognostic nomogram |
| url | https://doi.org/10.1002/cam4.6551 |
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