Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia

Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia

Abstract Myopia is a serious public health issue worldwide. Damage to retinal ganglion cells (RGCs) in the retina induces degeneration of the visual cortex, which is known as anterograde trans-synaptic degeneration (TSD). However, the role of TSD in myopia is still unknown. Here single-cell RNA-sequ...

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Main Authors: Ruixue Zhang, Yunxiao Xie, Miao Zhang, Zhiheng Li, Lijie Guo, Huixia Wei, Xiaomeng Li, Jizhao Xin, Zhaohui Yang, Ying Wen, Jiawen Hao, Xianglin Li, Xuewei Yin, Wenjun Jiang, Hongsheng Bi, Dadong Guo
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01489-y
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