Cardiac benign metastatic leiomyoma- a comprehensive review

Abstract Cardiac benign metastatic leiomyoma (BML) is a rare cardiac tumor that is usually asymptomatic, frequently misdiagnosed and may result in serious complications, including embolization, heart failure and death. This review highlights the importance of considering cardiac BML in the different...

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Main Authors: Pankaj Garg, Mostafa Ali, Mohammad Alomari, J. Kenneth Schoolmeester, Mark Edgar, Carolyn K. Landolfo, Steven Attia, Kevin P. Landolfo
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cardio-Oncology
Subjects:
Online Access:https://doi.org/10.1186/s40959-025-00336-3
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author Pankaj Garg
Mostafa Ali
Mohammad Alomari
J. Kenneth Schoolmeester
Mark Edgar
Carolyn K. Landolfo
Steven Attia
Kevin P. Landolfo
author_facet Pankaj Garg
Mostafa Ali
Mohammad Alomari
J. Kenneth Schoolmeester
Mark Edgar
Carolyn K. Landolfo
Steven Attia
Kevin P. Landolfo
author_sort Pankaj Garg
collection DOAJ
description Abstract Cardiac benign metastatic leiomyoma (BML) is a rare cardiac tumor that is usually asymptomatic, frequently misdiagnosed and may result in serious complications, including embolization, heart failure and death. This review highlights the importance of considering cardiac BML in the differential diagnosis of cardiac masses, especially in women with a history of uterine leiomyomas. This review summarizes the current knowledge about cardiac BML, including its demographics, clinical presentation, etio-pathogenesis, diagnosis, and management. The authors discuss the challenges associated with diagnosing cardiac BML and emphasize the importance of a thorough history, physical examination, and imaging studies. They also review the different treatment options for cardiac BML, including surgical resection and role of medical and surgical castration. Early diagnosis and management of cardiac BML is crucial to prevent complications. This review provides valuable insights for clinicians who may encounter this rare condition. By raising awareness of cardiac BML and its management strategies, this review can improve patient care and outcomes.
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series Cardio-Oncology
spelling doaj-art-0023016e8f664729b3cf85a2ac2fe63b2025-08-20T02:55:24ZengBMCCardio-Oncology2057-38042025-05-011111910.1186/s40959-025-00336-3Cardiac benign metastatic leiomyoma- a comprehensive reviewPankaj Garg0Mostafa Ali1Mohammad Alomari2J. Kenneth Schoolmeester3Mark Edgar4Carolyn K. Landolfo5Steven Attia6Kevin P. Landolfo7Department of Cardiothoracic Surgery, Mayo ClinicDepartment of Cardiothoracic Surgery, Mayo ClinicDepartment of Cardiothoracic Surgery, Mayo ClinicLaboratory Medicine and Pathology Department, Mayo ClinicLaboratory Medicine and Pathology Department, Mayo ClinicCardiovascular Diseases Department, Mayo ClinicHematology and Oncology Department, Mayo ClinicDepartment of Cardiothoracic Surgery, Mayo ClinicAbstract Cardiac benign metastatic leiomyoma (BML) is a rare cardiac tumor that is usually asymptomatic, frequently misdiagnosed and may result in serious complications, including embolization, heart failure and death. This review highlights the importance of considering cardiac BML in the differential diagnosis of cardiac masses, especially in women with a history of uterine leiomyomas. This review summarizes the current knowledge about cardiac BML, including its demographics, clinical presentation, etio-pathogenesis, diagnosis, and management. The authors discuss the challenges associated with diagnosing cardiac BML and emphasize the importance of a thorough history, physical examination, and imaging studies. They also review the different treatment options for cardiac BML, including surgical resection and role of medical and surgical castration. Early diagnosis and management of cardiac BML is crucial to prevent complications. This review provides valuable insights for clinicians who may encounter this rare condition. By raising awareness of cardiac BML and its management strategies, this review can improve patient care and outcomes.https://doi.org/10.1186/s40959-025-00336-3Cardiac tumorsCardiac benign metastatic leiomyomaSurgical treatmentGenetic studies
spellingShingle Pankaj Garg
Mostafa Ali
Mohammad Alomari
J. Kenneth Schoolmeester
Mark Edgar
Carolyn K. Landolfo
Steven Attia
Kevin P. Landolfo
Cardiac benign metastatic leiomyoma- a comprehensive review
Cardio-Oncology
Cardiac tumors
Cardiac benign metastatic leiomyoma
Surgical treatment
Genetic studies
title Cardiac benign metastatic leiomyoma- a comprehensive review
title_full Cardiac benign metastatic leiomyoma- a comprehensive review
title_fullStr Cardiac benign metastatic leiomyoma- a comprehensive review
title_full_unstemmed Cardiac benign metastatic leiomyoma- a comprehensive review
title_short Cardiac benign metastatic leiomyoma- a comprehensive review
title_sort cardiac benign metastatic leiomyoma a comprehensive review
topic Cardiac tumors
Cardiac benign metastatic leiomyoma
Surgical treatment
Genetic studies
url https://doi.org/10.1186/s40959-025-00336-3
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