IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells

IL-10/STAT5 axis suppresses miR-140 to upregulate B7-H4 expression in RAW264.7 cells

IntroductionSchistosomiasis japonica, a zoonotic parasitic disease, induces complex immune regulation during infection. The inflammatory responses and immunosuppressive mechanisms co-exist to maintain immune homeostasis in schistosomiasis. B7-H4 is a critical immune checkpoint molecule that modulate...

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Bibliographic Details
Main Authors: Dandan Zhu, Guo Chen, Pei Shen, Weiliang Fan, Chuxin Ji, Yinong Duan, Wenxi Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
miR-140
B7-H4
IL-10
STAT5
Schistosoma japonicum
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1613297/full
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