Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studies

Abstract Background Human precision-cut lung slices (hPCLS) are a unique platform for functional, mechanistic, and drug discovery studies in the field of respiratory research. However, tissue availability, generation, and cultivation time represent important challenges for their usage. Therefore, th...

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Bibliographic Details
Main Authors: M. Camila Melo-Narvaez, Fee Gölitz, Eshita Jain, Janine Gote-Schniering, Mircea Gabriel Stoleriu, Wilhelm Bertrams, Bernd Schmeck, Ali Önder Yildirim, Ursula Rauen, Timo Wille, Mareike Lehmann
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Respiratory Research
Subjects:
Human precision-cut lung slices (hPCLS)
3R
Long-term cold storage
Tissue preservation
Fibrosis
Human lung models
Online Access:https://doi.org/10.1186/s12931-025-03132-w
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