Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity
Air pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemiological and in vitro studies. Environmental air pollutants a...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/493894 |
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| author | Karine Andreau Melanie Leroux Aida Bouharrour |
| author_facet | Karine Andreau Melanie Leroux Aida Bouharrour |
| author_sort | Karine Andreau |
| collection | DOAJ |
| description | Air pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemiological and in vitro studies. Environmental air pollutants are a heterogeneous mixture of particles suspended into a liquid and gaseous phase which trigger the disruption of redox homeostasis—known under the term of cellular oxidative stress—in relation with the establishment of inflammation and cell death via necrosis, apoptosis, or autophagy. Activation or repression of the apoptotic process as an adaptative response to xenobiotics might lead to either acute or chronic toxicity. The purpose of this paper is to highlight the central role of oxidative stress induced by air pollutants and to focus on the subsequent cellular impacts ranging from cytoprotection to cytotoxicity by decreasing or stimulating apoptosis, respectively. |
| format | Article |
| id | doaj-art-000cda68d68a4ff1a83fd3fbb6cdd4b9 |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-000cda68d68a4ff1a83fd3fbb6cdd4b92025-02-03T01:28:39ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/493894493894Health and Cellular Impacts of Air Pollutants: From Cytoprotection to CytotoxicityKarine Andreau0Melanie Leroux1Aida Bouharrour2Laboratory of Molecular and Cellular Responses to Xenobiotics, Unit of Functional and Adaptive Biology (BFA), CNRS EAC 4413, University of Paris Diderot, Sorbonne Paris Cité, 75013 Paris, FranceLaboratory of Molecular and Cellular Responses to Xenobiotics, Unit of Functional and Adaptive Biology (BFA), CNRS EAC 4413, University of Paris Diderot, Sorbonne Paris Cité, 75013 Paris, FranceLaboratory of Molecular and Cellular Responses to Xenobiotics, Unit of Functional and Adaptive Biology (BFA), CNRS EAC 4413, University of Paris Diderot, Sorbonne Paris Cité, 75013 Paris, FranceAir pollution as one of the ravages of our modern societies is primarily linked to urban centers, industrial activities, or road traffic. These atmospheric pollutants have been incriminated in deleterious health effects by numerous epidemiological and in vitro studies. Environmental air pollutants are a heterogeneous mixture of particles suspended into a liquid and gaseous phase which trigger the disruption of redox homeostasis—known under the term of cellular oxidative stress—in relation with the establishment of inflammation and cell death via necrosis, apoptosis, or autophagy. Activation or repression of the apoptotic process as an adaptative response to xenobiotics might lead to either acute or chronic toxicity. The purpose of this paper is to highlight the central role of oxidative stress induced by air pollutants and to focus on the subsequent cellular impacts ranging from cytoprotection to cytotoxicity by decreasing or stimulating apoptosis, respectively.http://dx.doi.org/10.1155/2012/493894 |
| spellingShingle | Karine Andreau Melanie Leroux Aida Bouharrour Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity Biochemistry Research International |
| title | Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity |
| title_full | Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity |
| title_fullStr | Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity |
| title_full_unstemmed | Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity |
| title_short | Health and Cellular Impacts of Air Pollutants: From Cytoprotection to Cytotoxicity |
| title_sort | health and cellular impacts of air pollutants from cytoprotection to cytotoxicity |
| url | http://dx.doi.org/10.1155/2012/493894 |
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