Microstructured Waveguide Sensors for Point-of-Care Health Screening
Biosensor technologies in medicine, as in many other areas, are replacing labor-intensive methods of monitoring human health. This paper presents the results of experimental studies on label-free sensors based on a hollow core microstructured optical waveguide (HC-MOW) for human blood serum analysis...
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| Format: | Article |
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MDPI AG
2025-04-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/12/4/399 |
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| author | Svetlana S. Konnova Pavel A. Lepilin Anastasia A. Zanishevskaya Alexey Y. Gryaznov Natalia A. Kosheleva Victoria P. Ilinskaya Julia S. Skibina Valery V. Tuchin |
| author_facet | Svetlana S. Konnova Pavel A. Lepilin Anastasia A. Zanishevskaya Alexey Y. Gryaznov Natalia A. Kosheleva Victoria P. Ilinskaya Julia S. Skibina Valery V. Tuchin |
| author_sort | Svetlana S. Konnova |
| collection | DOAJ |
| description | Biosensor technologies in medicine, as in many other areas, are replacing labor-intensive methods of monitoring human health. This paper presents the results of experimental studies on label-free sensors based on a hollow core microstructured optical waveguide (HC-MOW) for human blood serum analysis. The MOWs with a hollow core of 247.5 µm in diameter were manufactured and used in our work. These parameters allow the hollow core to be filled with high-viscosity solutions due to the capillary properties of the fiber. Calculations of the spectral properties of the HC-MOW fiber were carried out and experimentally confirmed. Twenty-one blood serum samples from volunteers were analyzed using standard photometry (commercial kits) and an experimental biosensor. The obtained transmission spectra were processed by the principal component analysis method and conclusions were drawn about the possibility of using this biosensor in point-of-care medicine. A significant difference was shown between the blood serum of healthy patients and patients with confirmed diagnoses and a long history of cardiovascular system abnormalities. Algorithms for spectra processing using the Origin program are presented. |
| format | Article |
| id | doaj-art-000ba338e77d4a93ade7d7e7b92eadb6 |
| institution | DOAJ |
| issn | 2304-6732 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Photonics |
| spelling | doaj-art-000ba338e77d4a93ade7d7e7b92eadb62025-08-20T03:13:55ZengMDPI AGPhotonics2304-67322025-04-0112439910.3390/photonics12040399Microstructured Waveguide Sensors for Point-of-Care Health ScreeningSvetlana S. Konnova0Pavel A. Lepilin1Anastasia A. Zanishevskaya2Alexey Y. Gryaznov3Natalia A. Kosheleva4Victoria P. Ilinskaya5Julia S. Skibina6Valery V. Tuchin7SPE LLC “Nanostructured Glass Technology” (SPE LLC “NGT”), Saratov 410033, RussiaSPE LLC “Nanostructured Glass Technology” (SPE LLC “NGT”), Saratov 410033, RussiaSPE LLC “Nanostructured Glass Technology” (SPE LLC “NGT”), Saratov 410033, RussiaSPE LLC “Nanostructured Glass Technology” (SPE LLC “NGT”), Saratov 410033, RussiaDepartment of Hospital Therapy, Saratov State Medical University Named After V.I. Razumovsky, Saratov 410000, RussiaDepartment of Cardiology, Regional Clinical Hospital, Saratov 410053, RussiaSPE LLC “Nanostructured Glass Technology” (SPE LLC “NGT”), Saratov 410033, RussiaInstitution of Physics and Science Medical Center, Saratov State University, Saratov 410012, RussiaBiosensor technologies in medicine, as in many other areas, are replacing labor-intensive methods of monitoring human health. This paper presents the results of experimental studies on label-free sensors based on a hollow core microstructured optical waveguide (HC-MOW) for human blood serum analysis. The MOWs with a hollow core of 247.5 µm in diameter were manufactured and used in our work. These parameters allow the hollow core to be filled with high-viscosity solutions due to the capillary properties of the fiber. Calculations of the spectral properties of the HC-MOW fiber were carried out and experimentally confirmed. Twenty-one blood serum samples from volunteers were analyzed using standard photometry (commercial kits) and an experimental biosensor. The obtained transmission spectra were processed by the principal component analysis method and conclusions were drawn about the possibility of using this biosensor in point-of-care medicine. A significant difference was shown between the blood serum of healthy patients and patients with confirmed diagnoses and a long history of cardiovascular system abnormalities. Algorithms for spectra processing using the Origin program are presented.https://www.mdpi.com/2304-6732/12/4/399hollow core microstructured optical waveguidesHC-MOWblood serumbiosensorpoint-of-care diagnosticsprincipal component analysis |
| spellingShingle | Svetlana S. Konnova Pavel A. Lepilin Anastasia A. Zanishevskaya Alexey Y. Gryaznov Natalia A. Kosheleva Victoria P. Ilinskaya Julia S. Skibina Valery V. Tuchin Microstructured Waveguide Sensors for Point-of-Care Health Screening Photonics hollow core microstructured optical waveguides HC-MOW blood serum biosensor point-of-care diagnostics principal component analysis |
| title | Microstructured Waveguide Sensors for Point-of-Care Health Screening |
| title_full | Microstructured Waveguide Sensors for Point-of-Care Health Screening |
| title_fullStr | Microstructured Waveguide Sensors for Point-of-Care Health Screening |
| title_full_unstemmed | Microstructured Waveguide Sensors for Point-of-Care Health Screening |
| title_short | Microstructured Waveguide Sensors for Point-of-Care Health Screening |
| title_sort | microstructured waveguide sensors for point of care health screening |
| topic | hollow core microstructured optical waveguides HC-MOW blood serum biosensor point-of-care diagnostics principal component analysis |
| url | https://www.mdpi.com/2304-6732/12/4/399 |
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