Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth
Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism of action involves the selective activation of retinoic acid...
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MDPI AG
2025-03-01
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| author | Chun-Hua Wang Lu-Kai Wang Fu-Ming Tsai |
| author_facet | Chun-Hua Wang Lu-Kai Wang Fu-Ming Tsai |
| author_sort | Chun-Hua Wang |
| collection | DOAJ |
| description | Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism of action involves the selective activation of retinoic acid receptors (RAR-β and RAR-γ), which play important roles in regulating cell growth, differentiation, and apoptosis. By activating these receptors, tazarotene influences the expression of several downstream inducible genes, such as tazarotene-induced gene-1 (<i>TIG1</i>), <i>TIG2</i>, and <i>TIG3</i>. These genes play crucial roles in regulating melanoma cell proliferation, invasiveness, and immune responses in the tumor microenvironment. This review aims to provide a comprehensive overview of the current status of retinoid derivatives—particularly tazarotene—in melanoma treatment and the latest research regarding their molecular mechanisms. We will explore how tazarotene suppresses melanoma growth through gene regulation mechanisms and discuss its potential role in immune responses within the tumor microenvironment. Additionally, we assess the advantages and challenges of using tazarotene as a topical treatment and explore its future clinical applications. These studies contribute to a wider understanding of tazarotene’s antitumor mechanisms, providing a solid theoretical foundation for its potential as a therapeutic option for melanoma in situ. |
| format | Article |
| id | doaj-art-0008c06de4df48a5b78bc0d144dc260e |
| institution | OA Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-03-01 |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-0008c06de4df48a5b78bc0d144dc260e2025-08-20T02:17:20ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-03-0147423710.3390/cimb47040237Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell GrowthChun-Hua Wang0Lu-Kai Wang1Fu-Ming Tsai2Department of Dermatology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanOperation & Promotion Division, National Center for Biomodels, National Institutes of Applied Research, Taipei City 115, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanTazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism of action involves the selective activation of retinoic acid receptors (RAR-β and RAR-γ), which play important roles in regulating cell growth, differentiation, and apoptosis. By activating these receptors, tazarotene influences the expression of several downstream inducible genes, such as tazarotene-induced gene-1 (<i>TIG1</i>), <i>TIG2</i>, and <i>TIG3</i>. These genes play crucial roles in regulating melanoma cell proliferation, invasiveness, and immune responses in the tumor microenvironment. This review aims to provide a comprehensive overview of the current status of retinoid derivatives—particularly tazarotene—in melanoma treatment and the latest research regarding their molecular mechanisms. We will explore how tazarotene suppresses melanoma growth through gene regulation mechanisms and discuss its potential role in immune responses within the tumor microenvironment. Additionally, we assess the advantages and challenges of using tazarotene as a topical treatment and explore its future clinical applications. These studies contribute to a wider understanding of tazarotene’s antitumor mechanisms, providing a solid theoretical foundation for its potential as a therapeutic option for melanoma in situ.https://www.mdpi.com/1467-3045/47/4/237tazaroteneretinoic acidmelanomatazarotene-induced generetinoic acid receptorsretinoid X receptors |
| spellingShingle | Chun-Hua Wang Lu-Kai Wang Fu-Ming Tsai Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth Current Issues in Molecular Biology tazarotene retinoic acid melanoma tazarotene-induced gene retinoic acid receptors retinoid X receptors |
| title | Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth |
| title_full | Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth |
| title_fullStr | Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth |
| title_full_unstemmed | Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth |
| title_short | Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth |
| title_sort | exploring potential therapeutic applications of tazarotene gene regulation mechanisms and effects on melanoma cell growth |
| topic | tazarotene retinoic acid melanoma tazarotene-induced gene retinoic acid receptors retinoid X receptors |
| url | https://www.mdpi.com/1467-3045/47/4/237 |
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