Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions
Motor ability decline remains a major threat to the quality of life of the elderly. Although the later stages of aging co-exist with degenerative pathologies, the long process of aging is more complicated than a simple and gradual degeneration. To combat senescence and the associated late-stage dege...
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MDPI AG
2024-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/20/1684 |
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| author | Yizhi Li Yomna Badawi Stephen D. Meriney |
| author_facet | Yizhi Li Yomna Badawi Stephen D. Meriney |
| author_sort | Yizhi Li |
| collection | DOAJ |
| description | Motor ability decline remains a major threat to the quality of life of the elderly. Although the later stages of aging co-exist with degenerative pathologies, the long process of aging is more complicated than a simple and gradual degeneration. To combat senescence and the associated late-stage degeneration of the neuromuscular system, it is imperative to examine changes that occur during the long process of aging. Prior to late-stage degeneration, age-induced changes in the neuromuscular system trigger homeostatic plasticity. This unique phenomenon may be important for the maintenance of the neuromuscular system during the early stages of aging. In this review, we will focus on age-induced changes in neurotransmission at the neuromuscular junction, providing the potential mechanisms responsible for these changes. The goal is to highlight these key elements and their role in regulating neurotransmission, facilitating future research efforts to combat late-stage degeneration in the neuromuscular system by preserving the functional and structural integrity of these elements prior to the late stage of aging. |
| format | Article |
| id | doaj-art-000899e079ce4bbd8311c031e1f3a162 |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-000899e079ce4bbd8311c031e1f3a1622025-08-20T02:11:09ZengMDPI AGCells2073-44092024-10-011320168410.3390/cells13201684Age-Related Homeostatic Plasticity at Rodent Neuromuscular JunctionsYizhi Li0Yomna Badawi1Stephen D. Meriney2Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USADepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USADepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USAMotor ability decline remains a major threat to the quality of life of the elderly. Although the later stages of aging co-exist with degenerative pathologies, the long process of aging is more complicated than a simple and gradual degeneration. To combat senescence and the associated late-stage degeneration of the neuromuscular system, it is imperative to examine changes that occur during the long process of aging. Prior to late-stage degeneration, age-induced changes in the neuromuscular system trigger homeostatic plasticity. This unique phenomenon may be important for the maintenance of the neuromuscular system during the early stages of aging. In this review, we will focus on age-induced changes in neurotransmission at the neuromuscular junction, providing the potential mechanisms responsible for these changes. The goal is to highlight these key elements and their role in regulating neurotransmission, facilitating future research efforts to combat late-stage degeneration in the neuromuscular system by preserving the functional and structural integrity of these elements prior to the late stage of aging.https://www.mdpi.com/2073-4409/13/20/1684agingneuromuscular junctionsynaptic transmissionpresynaptic homeostatic plasticity |
| spellingShingle | Yizhi Li Yomna Badawi Stephen D. Meriney Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions Cells aging neuromuscular junction synaptic transmission presynaptic homeostatic plasticity |
| title | Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions |
| title_full | Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions |
| title_fullStr | Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions |
| title_full_unstemmed | Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions |
| title_short | Age-Related Homeostatic Plasticity at Rodent Neuromuscular Junctions |
| title_sort | age related homeostatic plasticity at rodent neuromuscular junctions |
| topic | aging neuromuscular junction synaptic transmission presynaptic homeostatic plasticity |
| url | https://www.mdpi.com/2073-4409/13/20/1684 |
| work_keys_str_mv | AT yizhili agerelatedhomeostaticplasticityatrodentneuromuscularjunctions AT yomnabadawi agerelatedhomeostaticplasticityatrodentneuromuscularjunctions AT stephendmeriney agerelatedhomeostaticplasticityatrodentneuromuscularjunctions |