Brain Reward System and Its Volumetric Investigations in Alcohol Addiction
It has been shown that structural changes occur in the brain in many types of addiction and can have an impact on maintaining addictive behavior, which can be improved with treatment. The study aimed to iden- tify structural changes in the brain’s reward system in alcohol use disorder. Structural ma...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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AVES Yayincilik
2024-12-01
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| Series: | Addicta: The Turkish Journal on Addictions |
| Online Access: | https://www.addicta.com.tr/en/brain-reward-system-and-its-volumetric-investigations-in-alcohol-addiction-13383 |
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| _version_ | 1841527651645259776 |
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| author | Muhammed Fatih Tabara Murad Atmaca Hanefi Yıldırım Onur Solmaz Muhammed Amir Essibayi Mehmet Gürkan Gurok |
| author_facet | Muhammed Fatih Tabara Murad Atmaca Hanefi Yıldırım Onur Solmaz Muhammed Amir Essibayi Mehmet Gürkan Gurok |
| author_sort | Muhammed Fatih Tabara |
| collection | DOAJ |
| description | It has been shown that structural changes occur in the brain in many types of addiction and can have an impact on maintaining addictive behavior, which can be improved with treatment. The study aimed to iden- tify structural changes in the brain’s reward system in alcohol use disorder. Structural magnetic resonance imaging was employed to compare the volumes of total white matter and gray matter, as well as those of the nucleus accumbens, ventral tegmental area, amygdala, and hippocampus between 15 individuals diag- nosed with alcohol use disorder and 17 healthy controls. The Michigan Alcoholism Screening Test, Severity of Alcohol Dependence Questionnaire, and Alcohol Use Disorders Identification Test were administered to the participants to reveal the pattern of alcohol use and severity of dependence. The group with alcohol use disorder exhibited a significant decrease in the volume of the right hippocampus. No differences were found between the two groups in terms of other brain regions. In conclusion, this study revealed a decrease in hip- pocampal volume in patients with alcohol use disorder. It is an indication that structural changes play a role in the etiology of cognitive impairments commonly seen in alcohol use disorder. |
| format | Article |
| id | doaj-art-00061b76b916459b96b114f054a70bcd |
| institution | Kabale University |
| issn | 2149-1305 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | AVES Yayincilik |
| record_format | Article |
| series | Addicta: The Turkish Journal on Addictions |
| spelling | doaj-art-00061b76b916459b96b114f054a70bcd2025-01-15T08:48:57ZengAVES YayincilikAddicta: The Turkish Journal on Addictions2149-13052024-12-0111324124810.5152/ADDICTA.2024.24076Brain Reward System and Its Volumetric Investigations in Alcohol AddictionMuhammed Fatih Tabara0Murad Atmaca1Hanefi Yıldırım2Onur Solmaz3Muhammed Amir Essibayi4Mehmet Gürkan Gurok5Department of Psychiatry, Fırat University School of Medicine, Elazığ, Türkiye Department of Psychiatry, Fırat University School of Medicine, Elazığ, Türkiye Department of Radiology, Fırat University School of Medicine, Elazığ, TürkiyeDepartment of Radiology, Fırat University School of Medicine, Elazığ, Türkiye Montefore Einstein Cerebrovascular Research Lab and Department of Neurological Surgery, Montefore Medical Center, Albert Einstein College of Medicine, NY, United StatesDepartment of Psychiatry, Fırat University School of Medicine, Elazığ, Türkiye It has been shown that structural changes occur in the brain in many types of addiction and can have an impact on maintaining addictive behavior, which can be improved with treatment. The study aimed to iden- tify structural changes in the brain’s reward system in alcohol use disorder. Structural magnetic resonance imaging was employed to compare the volumes of total white matter and gray matter, as well as those of the nucleus accumbens, ventral tegmental area, amygdala, and hippocampus between 15 individuals diag- nosed with alcohol use disorder and 17 healthy controls. The Michigan Alcoholism Screening Test, Severity of Alcohol Dependence Questionnaire, and Alcohol Use Disorders Identification Test were administered to the participants to reveal the pattern of alcohol use and severity of dependence. The group with alcohol use disorder exhibited a significant decrease in the volume of the right hippocampus. No differences were found between the two groups in terms of other brain regions. In conclusion, this study revealed a decrease in hip- pocampal volume in patients with alcohol use disorder. It is an indication that structural changes play a role in the etiology of cognitive impairments commonly seen in alcohol use disorder.https://www.addicta.com.tr/en/brain-reward-system-and-its-volumetric-investigations-in-alcohol-addiction-13383 |
| spellingShingle | Muhammed Fatih Tabara Murad Atmaca Hanefi Yıldırım Onur Solmaz Muhammed Amir Essibayi Mehmet Gürkan Gurok Brain Reward System and Its Volumetric Investigations in Alcohol Addiction Addicta: The Turkish Journal on Addictions |
| title | Brain Reward System and Its Volumetric Investigations in Alcohol Addiction |
| title_full | Brain Reward System and Its Volumetric Investigations in Alcohol Addiction |
| title_fullStr | Brain Reward System and Its Volumetric Investigations in Alcohol Addiction |
| title_full_unstemmed | Brain Reward System and Its Volumetric Investigations in Alcohol Addiction |
| title_short | Brain Reward System and Its Volumetric Investigations in Alcohol Addiction |
| title_sort | brain reward system and its volumetric investigations in alcohol addiction |
| url | https://www.addicta.com.tr/en/brain-reward-system-and-its-volumetric-investigations-in-alcohol-addiction-13383 |
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