Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs.
Oropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC. Mice lacking...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-07-01
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| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012302&type=printable |
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| author | Felix E Y Aggor Martinna Bertolini Bianca M Coleman Tiffany C Taylor Nicole O Ponde Sarah L Gaffen |
| author_facet | Felix E Y Aggor Martinna Bertolini Bianca M Coleman Tiffany C Taylor Nicole O Ponde Sarah L Gaffen |
| author_sort | Felix E Y Aggor |
| collection | DOAJ |
| description | Oropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC. Mice lacking IL-17RA and IL-22RA1 exhibited high fungal loads in esophagus- and intestinal tract, severe weight loss, and symptoms of colitis. Ultimately, mice succumbed to infection. Dual loss of IL-17RA and IL-22RA impaired expression of small proline rich proteins (SPRRs), a class of antimicrobial effectors not previously linked to fungal immunity. Sprr2a1 exhibited direct candidacidal activity in vitro, and Sprr1-3a-/- mice were susceptible to OPC. Thus, cooperative actions of Type 17 cytokines mediate oral mucosal anti-Candida defenses and reveal a role for SPRRs. |
| format | Article |
| id | doaj-art-00057ee8a517475cb226bbae4236d470 |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-00057ee8a517475cb226bbae4236d4702025-08-20T03:51:19ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-07-01207e101230210.1371/journal.ppat.1012302Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs.Felix E Y AggorMartinna BertoliniBianca M ColemanTiffany C TaylorNicole O PondeSarah L GaffenOropharyngeal candidiasis (OPC) is the most common human fungal infection, arising typically from T cell immune impairments. IL-17 and IL-22 contribute individually to OPC responses, but here we demonstrate that the combined actions of both cytokines are essential for resistance to OPC. Mice lacking IL-17RA and IL-22RA1 exhibited high fungal loads in esophagus- and intestinal tract, severe weight loss, and symptoms of colitis. Ultimately, mice succumbed to infection. Dual loss of IL-17RA and IL-22RA impaired expression of small proline rich proteins (SPRRs), a class of antimicrobial effectors not previously linked to fungal immunity. Sprr2a1 exhibited direct candidacidal activity in vitro, and Sprr1-3a-/- mice were susceptible to OPC. Thus, cooperative actions of Type 17 cytokines mediate oral mucosal anti-Candida defenses and reveal a role for SPRRs.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012302&type=printable |
| spellingShingle | Felix E Y Aggor Martinna Bertolini Bianca M Coleman Tiffany C Taylor Nicole O Ponde Sarah L Gaffen Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs. PLoS Pathogens |
| title | Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs. |
| title_full | Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs. |
| title_fullStr | Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs. |
| title_full_unstemmed | Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs. |
| title_short | Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs. |
| title_sort | combinatorial actions of il 22 and il 17 drive optimal immunity to oral candidiasis through sprrs |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012302&type=printable |
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