Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise
Chronic wounds, including diabetic foot ulcers and pressure sores, are becoming more prevalent due to aging populations and increased metabolic problems. These wounds often persist due to impaired healing, chronic inflammation, oxidative stress, and infections caused by multidrug-resistant pathogens...
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2025-06-01
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| author | Milind Umekar Anis Ahmad Chaudhary Monali Manghani Supriya Shidhaye Pratiksha Khajone Jayashri Mahore Hassan Ahmad Rudayni Rashmi Trivedi |
| author_facet | Milind Umekar Anis Ahmad Chaudhary Monali Manghani Supriya Shidhaye Pratiksha Khajone Jayashri Mahore Hassan Ahmad Rudayni Rashmi Trivedi |
| author_sort | Milind Umekar |
| collection | DOAJ |
| description | Chronic wounds, including diabetic foot ulcers and pressure sores, are becoming more prevalent due to aging populations and increased metabolic problems. These wounds often persist due to impaired healing, chronic inflammation, oxidative stress, and infections caused by multidrug-resistant pathogens, making conventional treatments—including antibiotics and antiseptics—largely inadequate. This creates an urgent need for advanced, biologically responsive therapies that can both combat infection and promote tissue regeneration. Probiotics have surfaced as a viable option owing to their capacity to regulate immune responses, impede pathogenic biofilms, and generate antibacterial and antioxidant metabolites. However, their clinical application is limited by poor viability, sensitivity to environmental conditions, and short retention at wound sites. Nanotechnology-based delivery systems address these limitations by protecting probiotics from degradation, enhancing site-specific delivery, and enabling controlled, stimuli-responsive release. Encapsulation techniques using materials like chitosan, PLGA, liposomes, nanogels, nanofibers, and microneedles have shown significant success in improving wound healing outcomes in preclinical and clinical models. This review summarizes the current landscape of chronic wound challenges and presents recent advances in probiotic-loaded nanotechnologies. It explores various nano-delivery systems, their mechanisms of action, biological effects, and therapeutic outcomes, highlighting the synergy between probiotics and nanocarriers as a novel, multifaceted strategy for managing chronic wounds. |
| format | Article |
| id | doaj-art-0005693af42b4df688bb3cef9491a85d |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj-art-0005693af42b4df688bb3cef9491a85d2025-08-20T03:32:27ZengMDPI AGPharmaceutics1999-49232025-06-0117780510.3390/pharmaceutics17070805Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical PromiseMilind Umekar0Anis Ahmad Chaudhary1Monali Manghani2Supriya Shidhaye3Pratiksha Khajone4Jayashri Mahore5Hassan Ahmad Rudayni6Rashmi Trivedi7Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur 441002, Maharashtra, IndiaDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartment of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur 441002, Maharashtra, IndiaDepartment of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur 441002, Maharashtra, IndiaDepartment of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur 441002, Maharashtra, IndiaDepartment of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (bk), Pune 411041, Maharashtra, IndiaDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartment of Quality Assurance, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur 441002, Maharashtra, IndiaChronic wounds, including diabetic foot ulcers and pressure sores, are becoming more prevalent due to aging populations and increased metabolic problems. These wounds often persist due to impaired healing, chronic inflammation, oxidative stress, and infections caused by multidrug-resistant pathogens, making conventional treatments—including antibiotics and antiseptics—largely inadequate. This creates an urgent need for advanced, biologically responsive therapies that can both combat infection and promote tissue regeneration. Probiotics have surfaced as a viable option owing to their capacity to regulate immune responses, impede pathogenic biofilms, and generate antibacterial and antioxidant metabolites. However, their clinical application is limited by poor viability, sensitivity to environmental conditions, and short retention at wound sites. Nanotechnology-based delivery systems address these limitations by protecting probiotics from degradation, enhancing site-specific delivery, and enabling controlled, stimuli-responsive release. Encapsulation techniques using materials like chitosan, PLGA, liposomes, nanogels, nanofibers, and microneedles have shown significant success in improving wound healing outcomes in preclinical and clinical models. This review summarizes the current landscape of chronic wound challenges and presents recent advances in probiotic-loaded nanotechnologies. It explores various nano-delivery systems, their mechanisms of action, biological effects, and therapeutic outcomes, highlighting the synergy between probiotics and nanocarriers as a novel, multifaceted strategy for managing chronic wounds.https://www.mdpi.com/1999-4923/17/7/805chronic woundsprobioticsnanotechnologywound healingnanoformulationsdrug delivery systems |
| spellingShingle | Milind Umekar Anis Ahmad Chaudhary Monali Manghani Supriya Shidhaye Pratiksha Khajone Jayashri Mahore Hassan Ahmad Rudayni Rashmi Trivedi Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise Pharmaceutics chronic wounds probiotics nanotechnology wound healing nanoformulations drug delivery systems |
| title | Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise |
| title_full | Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise |
| title_fullStr | Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise |
| title_full_unstemmed | Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise |
| title_short | Probiotics in Nanotechnology-Driven Wound Healing: From Mechanistic Insight to Clinical Promise |
| title_sort | probiotics in nanotechnology driven wound healing from mechanistic insight to clinical promise |
| topic | chronic wounds probiotics nanotechnology wound healing nanoformulations drug delivery systems |
| url | https://www.mdpi.com/1999-4923/17/7/805 |
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