Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics
The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the per...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2019-04-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/1011 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849699954615910400 |
|---|---|
| author | N. V. Dmitrieva M. V. Eidelshtein V. V. Aginova I. N. Perukhova Z. V. Grigorievskaya N. S. Bagirova I. V. Tereshchenko E. V. Kulaga I. A. Klyuchnikova E. N. Sokolova E. A. Shek E. Yu. Skleenova |
| author_facet | N. V. Dmitrieva M. V. Eidelshtein V. V. Aginova I. N. Perukhova Z. V. Grigorievskaya N. S. Bagirova I. V. Tereshchenko E. V. Kulaga I. A. Klyuchnikova E. N. Sokolova E. A. Shek E. Yu. Skleenova |
| author_sort | N. V. Dmitrieva |
| collection | DOAJ |
| description | The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resistant to piperacillin/tazobactam was 20.1–12.9 %, to ceftazidime – 33.0–32.9 %, to cefepime – 25.6–32.9 %, ciprofloxacin – 36.8–43.8 %, amikacin – 23.8–24.9 %. No statistically significant differences were found (p>0.05). However, an increase in the number of car-R strains from 31.7 to 43.8 % was observed (p<0.05). of 7 strains of P. aeruginosainvestigated for the presence of acquired carbapenemases, the production of metal-beta-lactamase of group Vimwas detected in 2 strains, and class acarbapenemases of the gEs-5 group in one strain.Conclusion. P. aeruginosaresistance to all antibiotic groups did not exceed 50 % and remained almost unchanged for 3 years, with the exception of the increase in car-R strains. three out of 7 (42.9 %) carbapenem-resistant strains were genetically stable. |
| format | Article |
| id | doaj-art-0004cc96095c404bbb1e14cd3c846a69 |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-0004cc96095c404bbb1e14cd3c846a692025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682019-04-01182283410.21294/1814-4861-2019-18-2-28-34623Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinicsN. V. Dmitrieva0M. V. Eidelshtein1V. V. Aginova2I. N. Perukhova3Z. V. Grigorievskaya4N. S. Bagirova5I. V. Tereshchenko6E. V. Kulaga7I. A. Klyuchnikova8E. N. Sokolova9E. A. Shek10E. Yu. Skleenova11N.N. Blokhin National Medical Research Center of Oncology.Research Institute of Antimicrobial Chemotherapy, Smolensk State Medical University.N.N. Blokhin National Medical Research Center of Oncology; Medical college №1.N.N. Blokhin National Medical Research Center of Oncology.N.N. Blokhin National Medical Research Center of Oncology.N.N. Blokhin National Medical Research Center of Oncology.N.N. Blokhin National Medical Research Center of Oncology.N.N. Blokhin National Medical Research Center of Oncology.N.N. Blokhin National Medical Research Center of Oncology.N.N. Blokhin National Medical Research Center of Oncology.Research Institute of Antimicrobial Chemotherapy, Smolensk State Medical University.Research Institute of Antimicrobial Chemotherapy, Smolensk State Medical University.The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resistant to piperacillin/tazobactam was 20.1–12.9 %, to ceftazidime – 33.0–32.9 %, to cefepime – 25.6–32.9 %, ciprofloxacin – 36.8–43.8 %, amikacin – 23.8–24.9 %. No statistically significant differences were found (p>0.05). However, an increase in the number of car-R strains from 31.7 to 43.8 % was observed (p<0.05). of 7 strains of P. aeruginosainvestigated for the presence of acquired carbapenemases, the production of metal-beta-lactamase of group Vimwas detected in 2 strains, and class acarbapenemases of the gEs-5 group in one strain.Conclusion. P. aeruginosaresistance to all antibiotic groups did not exceed 50 % and remained almost unchanged for 3 years, with the exception of the increase in car-R strains. three out of 7 (42.9 %) carbapenem-resistant strains were genetically stable.https://www.siboncoj.ru/jour/article/view/1011pseudomonas aeruginosacancer patientscarbapenemase productsvimgesnosocomial infectionsantibacterial drugs |
| spellingShingle | N. V. Dmitrieva M. V. Eidelshtein V. V. Aginova I. N. Perukhova Z. V. Grigorievskaya N. S. Bagirova I. V. Tereshchenko E. V. Kulaga I. A. Klyuchnikova E. N. Sokolova E. A. Shek E. Yu. Skleenova Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics Сибирский онкологический журнал pseudomonas aeruginosa cancer patients carbapenemase products vim ges nosocomial infections antibacterial drugs |
| title | Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics |
| title_full | Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics |
| title_fullStr | Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics |
| title_full_unstemmed | Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics |
| title_short | Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics |
| title_sort | nosocomial infections causedby pseudomonas aeruginosa in cancer clinics |
| topic | pseudomonas aeruginosa cancer patients carbapenemase products vim ges nosocomial infections antibacterial drugs |
| url | https://www.siboncoj.ru/jour/article/view/1011 |
| work_keys_str_mv | AT nvdmitrieva nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT mveidelshtein nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT vvaginova nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT inperukhova nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT zvgrigorievskaya nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT nsbagirova nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT ivtereshchenko nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT evkulaga nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT iaklyuchnikova nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT ensokolova nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT eashek nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics AT eyuskleenova nosocomialinfectionscausedbypseudomonasaeruginosaincancerclinics |