Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus
Purpose: To compare topographic, pachymetric and epithelial distribution patterns of clinically unaffected fellow eyes of patients with asymmetric keratoconus (AKC) with those of normal controls and keratoconic fellow eyes. Methods: A prospective, observational study was conducted at a tertiary care...
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| Language: | English |
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Elsevier
2025-09-01
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| Series: | JFO Open Ophthalmology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949889924000503 |
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| author | Rajneesh Dhiman Barkha Gupta Arun Kumar Jain Amit Gup Jagat Ram Chintan Malhotra |
| author_facet | Rajneesh Dhiman Barkha Gupta Arun Kumar Jain Amit Gup Jagat Ram Chintan Malhotra |
| author_sort | Rajneesh Dhiman |
| collection | DOAJ |
| description | Purpose: To compare topographic, pachymetric and epithelial distribution patterns of clinically unaffected fellow eyes of patients with asymmetric keratoconus (AKC) with those of normal controls and keratoconic fellow eyes. Methods: A prospective, observational study was conducted at a tertiary care center, in which twenty-five clinically unaffected fellow eyes in patients with AKC were compared to 25 keratoconic fellow eyes and 67 normal controls. Pachymetric and epithelial thicknesses in the central 2 mm and 8 octants in the 2–5 mm and 5–7 mm zones were compared using Spectral Domain Optical Coherence Tomography (SDOCT). Scheimpflug derived topography was also compared. Results: Mean simulated keratometry of fellow eyes (43.6D ± 1.34 D) was comparable to that of control eyes (43.85D ± 1.57 D) (p > 0.99) and less than that of keratoconic eyes (47.08D ± 4.62 D) (p = 0.004). Central corneal and epithelial thicknesses of fellow eyes (474.28 ± 40.27 μm, 52.76 ± 7.45 μm, respectively) were less than in control eyes (505.97 ± 30.12 μm, 60.48 ± 8.37 μm) (p < 0.001 and p = 0.006, respectively) but comparable to those of keratoconic eyes (470.48 ± 44.19 μm, 52.48 ± 8.00 μm) (p > 0.99). Pachymetric differences of radially opposite octants in the 2–5 mm zone demonstrated thinning in the inferior and inferotemporal octants of fellow eyes which was greater than that seen in control eyes (p = 0.017 and 0.04, respectively) Conclusion: Reduced central epithelial thickness and greater pachymetric differences in radially opposite octants of the mid-peripheral cornea may be suggestive of susceptibility to ectasia despite normal topography. |
| format | Article |
| id | doaj-art-0000f1869e0b4a049d654e8dec01b556 |
| institution | Kabale University |
| issn | 2949-8899 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
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| series | JFO Open Ophthalmology |
| spelling | doaj-art-0000f1869e0b4a049d654e8dec01b5562025-08-20T03:55:22ZengElsevierJFO Open Ophthalmology2949-88992025-09-011110012610.1016/j.jfop.2024.100126Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconusRajneesh Dhiman0Barkha Gupta1Arun Kumar Jain2Amit Gup3Jagat Ram4Chintan Malhotra5Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160022, IndiaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160022, IndiaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160022, IndiaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160022, IndiaAdvanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160022, IndiaCorresponding author.; Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160022, IndiaPurpose: To compare topographic, pachymetric and epithelial distribution patterns of clinically unaffected fellow eyes of patients with asymmetric keratoconus (AKC) with those of normal controls and keratoconic fellow eyes. Methods: A prospective, observational study was conducted at a tertiary care center, in which twenty-five clinically unaffected fellow eyes in patients with AKC were compared to 25 keratoconic fellow eyes and 67 normal controls. Pachymetric and epithelial thicknesses in the central 2 mm and 8 octants in the 2–5 mm and 5–7 mm zones were compared using Spectral Domain Optical Coherence Tomography (SDOCT). Scheimpflug derived topography was also compared. Results: Mean simulated keratometry of fellow eyes (43.6D ± 1.34 D) was comparable to that of control eyes (43.85D ± 1.57 D) (p > 0.99) and less than that of keratoconic eyes (47.08D ± 4.62 D) (p = 0.004). Central corneal and epithelial thicknesses of fellow eyes (474.28 ± 40.27 μm, 52.76 ± 7.45 μm, respectively) were less than in control eyes (505.97 ± 30.12 μm, 60.48 ± 8.37 μm) (p < 0.001 and p = 0.006, respectively) but comparable to those of keratoconic eyes (470.48 ± 44.19 μm, 52.48 ± 8.00 μm) (p > 0.99). Pachymetric differences of radially opposite octants in the 2–5 mm zone demonstrated thinning in the inferior and inferotemporal octants of fellow eyes which was greater than that seen in control eyes (p = 0.017 and 0.04, respectively) Conclusion: Reduced central epithelial thickness and greater pachymetric differences in radially opposite octants of the mid-peripheral cornea may be suggestive of susceptibility to ectasia despite normal topography.http://www.sciencedirect.com/science/article/pii/S2949889924000503KeratoconusAsymmetric keratoconusClinically unaffected fellow eyesPachymetryEpithelial thicknessSDOCT |
| spellingShingle | Rajneesh Dhiman Barkha Gupta Arun Kumar Jain Amit Gup Jagat Ram Chintan Malhotra Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus JFO Open Ophthalmology Keratoconus Asymmetric keratoconus Clinically unaffected fellow eyes Pachymetry Epithelial thickness SDOCT |
| title | Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus |
| title_full | Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus |
| title_fullStr | Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus |
| title_full_unstemmed | Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus |
| title_short | Topographic, pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus |
| title_sort | topographic pachymetric and epithelial thickness distribution patterns in clinically unaffected fellow eyes of patients with asymmetric keratoconus |
| topic | Keratoconus Asymmetric keratoconus Clinically unaffected fellow eyes Pachymetry Epithelial thickness SDOCT |
| url | http://www.sciencedirect.com/science/article/pii/S2949889924000503 |
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