Takayama first became known for his toughness after he began competing in mixed martial arts, when he took part in one of the most famous fights in MMA history at PRIDE 21 against Don Frye. Through his career Takayama had several career-threatening injuries, including a stroke after a match against Kensuke Sasaki in 2004. Takayama's career ended with a spinal cord injury in May 2017, which left him paralyzed from the shoulders down.
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