Incorporating Non-Coding Annotations into Rare Variant Analysis. by Tom G Richardson, Colin Campbell, Nicholas J Timpson, Tom R Gaunt

Get full text

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization. by Eleanor Sanderson, Tom G Richardson, Tim T Morris, Kate Tilling, George Davey Smith

Get full text

Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study by Sweta Pathak, Tom G. Richardson, Eleanor Sanderson, Bjørn Olav Åsvold, Laxmi Bhatta, Ben M. Brumpton

Get full text

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation. by Tom G Richardson, Genevieve M Leyden, Qin Wang, Joshua A Bell, Benjamin Elsworth, George Davey Smith, Michael V Holmes

Get full text

Structural and population-based evaluations of TBC1D1 p.Arg125Trp. by Tom G Richardson, Elaine C Thomas, Richard B Sessions, Debbie A Lawlor, Jeremy M Tavaré, Ian N M Day

Get full text

A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure. by Katie O'Nunain, Chloe Park, Helena Urquijo, Genevieve M Leyden, Alun D Hughes, George Davey Smith, Tom G Richardson

Get full text

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. by Tom G Richardson, Eleanor Sanderson, Tom M Palmer, Mika Ala-Korpela, Brian A Ference, George Davey Smith, Michael V Holmes

Get full text

A Protein Domain and Family Based Approach to Rare Variant Association Analysis. by Tom G Richardson, Hashem A Shihab, Manuel A Rivas, Mark I McCarthy, Colin Campbell, Nicholas J Timpson, Tom R Gaunt

Get full text

The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases by Marek J. Konieczny, Murad Omarov, Lanyue Zhang, Rainer Malik, Tom G. Richardson, Sebastian-Edgar Baumeister, Jürgen Bernhagen, Martin Dichgans, Marios K. Georgakis

Get full text

Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study. by Si Fang, James Yarmolinsky, Dipender Gill, Caroline J Bull, Claire M Perks, PRACTICAL Consortium, George Davey Smith, Tom R Gaunt, Tom G Richardson

Get full text

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis. by James Yarmolinsky, Virginia Díez-Obrero, Tom G Richardson, Marie Pigeyre, Jennifer Sjaarda, Guillaume Paré, Venexia M Walker, Emma E Vincent, Vanessa Y Tan, Mireia Obón-Santacana, Demetrius Albanes, Jochen Hampe, Andrea Gsur, Heather Hampel, Rish K Pai, Mark Jenkins, Steven Gallinger, Graham Casey, Wei Zheng, Christopher I Amos, International Lung Cancer Consortium, PRACTICAL consortium, MEGASTROKE consortium, George Davey Smith, Richard M Martin, Victor Moreno

Get full text

A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank by Ana Torralbo, Jonathan M. Davitte, Damien C. Croteau-Chonka, Cai Ytsma, Chris Tomlinson, Natalie K. Fitzpatrick, Sheng-Chia Chung, Ghazaleh Fatemifar, Adrian S. Cortes, Tom G. Richardson, Matthew Barclay, Julia Carrasco-Zanini, Chris Finan, Harry Hemingway, Aroon D. Hingorani, Valerie Kuan, Claudia Langenberg, Georgios Lyratzopoulos, R. Thomas Lumbers, Maik Pietzner, Anoop D. Shah, Johan H. Thygesen, Natalie Zelenka, John C. Whittaker, Margaret G. Ehm, Spiros Denaxas

Get full text

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome. by Denis A Baird, Jimmy Z Liu, Jimmy Z Liu, Jie Zheng, Solveig K Sieberts, Thanneer Perumal, Benjamin Elsworth, Tom G Richardson, Chia-Yen Chen, Minerva M Carrasquillo, Mariet Allen, Joseph S Reddy, Philip L De Jager, Nilufer Ertekin-Taner, Lara M Mangravite, Ben Logsdon, Karol Estrada, Philip C Haycock, Gibran Hemani, Heiko Runz, George Davey Smith, Tom R Gaunt, AMP-AD eQTL working group

Get full text

Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes by Emma Hazelwood, Daffodil M. Canson, Benedita Deslandes, Xuemin Wang, Pik Fang Kho, Danny Legge, Andrei-Emil Constantinescu, Matthew A. Lee, D. Timothy Bishop, Andrew T. Chan, Stephen B. Gruber, Jochen Hampe, Loic Le Marchand, Michael O. Woods, Rish K. Pai, Stephanie L. Schmit, Jane C. Figueiredo, Wei Zheng, Jeroen R. Huyghe, Neil Murphy, Marc J. Gunter, Tom G. Richardson, Vicki L. J. Whitehall, Emma E. Vincent, Dylan M. Glubb, Tracy A. O’Mara

Get full text