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Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques by Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha, Sonnet S. Davis, Valerie Warkins, Dan Xia, Brigitte Nuscher, Anna Berghofer, Marvin Reich, Astrid F. Feiten, Kai Schlepckow, Michael Willem, Stefan F. Lichtenthaler, Joseph W. Lewcock, Kathryn M. Monroe, Matthias Brendel, Christian Haass
Published 2025-08-01Get full text
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Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial by Brittany N. Flores, Seungyoon B. Yu, Isaac V. Cohen, Melania H. Fanok, Wei Luan, Romeo D. Maciuca, Linus D. Sun, Richard M. Tsai, Maurits Vissers, Lars Smits, Tommy M. Bunte, Anna Bakardjiev, Srijana Balasundar, Meredith E. K. Calvert, Marcus Y. Chin, Sarah K. Dobbins, William E. Dowdle, Meng Fang, Jules A. A. C. Heuberger, Connie L. Ha, Fen Huang, Takashi Miyamoto, Maksim Osipov, Lidia Madrid San Martin, Katie Saund, David Tatarakis, Anthony Q. Vu, Chenling Xiong, Gene W. Yeo, Geert Jan Groeneveld, Leonard H. van den Berg, Shyeilla Dhuria, Anthony A. Estrada, Danna Jennings, Thomas Sandmann, Carole Ho, Kimberly Scearce-Levie, Ernie Yulyaningsih, Adam K. Walker, Gilbert Di Paolo, Lesley A. Kane, Matthew D. Troyer, Joseph W. Lewcock
Published 2025-08-01Get full text
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