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The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abu... by Joseph K McKenna, Yalan Wu, Praveen Sonkusre, Caleb K Sinclear, Raj Chari, Andres M Lebensohn
Published 2025-05-01Get full text
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Deciphering Squamous Cell Carcinoma Using Multidimensional Genomic Approaches by Ewan A. Gibb, Katey S. S. Enfield, Ivy F. L. Tsui, Raj Chari, Stephen Lam, Carlos E. Alvarez, Wan L. Lam
Published 2011-01-01Get full text
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3
Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping by Siddhardha S. Maligireddy, Mariana D. Mandler, Judith C. Lunger, Madeline Yuen, Sneha Kulkarni, Alexendar R. Perez, Christina M. Fitzsimmons, Daniel R. Crooks, Raj Chari, W. Marston Linehan, Pedro J. Batista
Published 2025-09-01Get full text
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4
A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation. by Christopher E Smith, Yien Che Tsai, Yu-He Liang, Domarin Khago, Jennifer Mariano, Jess Li, Sergey G Tarasov, Emma Gergel, Borong Tsai, Matthew Villaneuva, Michelle E Clapp, Valentin Magidson, Raj Chari, R Andrew Byrd, Xinhua Ji, Allan M Weissman
Published 2021-12-01Get full text
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5
Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition by Haojian Li, Takashi Furusawa, Renzo Cavero, Yunjie Xiao, Raj Chari, Xiaolin Wu, David Sun, Oliver Hartmann, Anjali Dhall, Ronald Holewinski, Thorkell Andresson, Baktiar Karim, Marina Villamor-Payà, Devorah Gallardo, Chi-Ping Day, Lipika R. Pal, Nishanth Ulhas Nair, Eytan Ruppin, Mirit I. Aladjem, Yves Pommier, Markus E. Diefenbacher, Jung Mi Lim, Rodney L. Levine, Travis H. Stracker, Urbain Weyemi
Published 2025-03-01Get full text
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6
A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins by Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters
Published 2024-03-01Get full text
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