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Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR. by Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan, Pierre Boivin, Vihasi Jani, Aaron J Cantor, Akshay Tambe, Mary Haak-Frendscho, Mary J Janatpour, Spencer C Wei
Published 2025-01-01Get full text
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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines by Spencer C. Wei, Aaron J. Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Ashil Bans, Prachi Khekare, Suhani Gupta, Jonathan Wang, Craig Soares, Radwan Kiwan, Jieun Lee, Shannon McCawley, Vihasi Jani, Weng In Leong, Pawan K. Shahi, Jean Chan, Pierre Boivin, Peter Otoupal, Bikash R. Pattnaik, David M. Gamm, Krishanu Saha, Benjamin G. Gowen, Mary Haak-Frendscho, Mary J. Janatpour, Adam P. Silverman
Published 2025-01-01Get full text
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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines. by Spencer C Wei, Aaron J Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Ashil Bans, Prachi Khekare, Suhani Gupta, Jonathan Wang, Craig Soares, Radwan Kiwan, Jieun Lee, Shannon McCawley, Vihasi Jani, Weng In Leong, Pawan K Shahi, Jean Chan, Pierre Boivin, Peter Otoupal, Bikash R Pattnaik, David M Gamm, Krishanu Saha, Benjamin G Gowen, Mary Haak-Frendscho, Mary J Janatpour, Adam P Silverman
Published 2025-01-01Get full text
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