A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis: the UPSIDE study protocol by Vanessa Smith, Ellen De Langhe, Jacob M van Laar, Alexandre E Voskuyl, Madelon C Vonk, Roger Hesselstrand, Ulrich A Walker, Dirk M Wuttge, Reinhard E Voll, Arjan A van de Loosdrecht, Julia Spierings, Joerg Henes, Anna van Rhenen, Paco MW Welsing, Anne CA Marijnissen, Nicoletta Del Papa, Daan Dierickx, Karina R Gheorghe, Tessa Kerre, Per Ljungman, Erik WAF Marijt, Miro Mayer, Marc Schmalzing, Roland Schroers, Jeska K de Vries-Bouwstra

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