Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype by Ivana Iveljic, Megan Young, Elvira Corhodzic, Fenn Cullen, Hiran A. Prag, Michael P. Murphy, Dunja Aksentijevic

Get full text

Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. by Edward T Chouchani, Carmen Methner, Guido Buonincontri, Chou-Hui Hu, Angela Logan, Stephen J Sawiak, Michael P Murphy, Thomas Krieg

Get full text

Ninety-Day Outcomes in Primary Hypercoagulable Disease Patients Undergoing Total Joint Arthroplasty Vs Normal: A Matched Case-Control Series by Amir M. Boubekri, MD, Michael P. Murphy, MD, Nicolas Jozefowski, BS, Nicholas M. Brown, MD, Harold W. Rees, MD

Get full text

Modeling integration site data for safety assessment with MELISSA by Tsai-Yu Lin, Giacomo Ceoldo, Kimberley House, Matthew Welty, Thao Thi Dang, Denise Klatt, Christian Brendel, Michael P. Murphy, Kenneth Cornetta, Danilo Pellin

Get full text

Effects of the Mitochondria-Targeted Antioxidant Mitoquinone in Murine Acute Pancreatitis by Wei Huang, Nicole Cash, Li Wen, Peter Szatmary, Rajarshi Mukherjee, Jane Armstrong, Michael Chvanov, Alexei V. Tepikin, Michael P. Murphy, Robert Sutton, David N. Criddle

Get full text

Maternal MitoQ Treatment Is Protective Against Programmed Alterations in CYP Activity Due to Antenatal Dexamethasone by Millicent G. A. Bennett, Ashley S. Meakin, Kimberley J. Botting-Lawford, Youguo Niu, Sage G. Ford, Michael P. Murphy, Michael D. Wiese, Dino A. Giussani, Janna L. Morrison

Get full text

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS by Alba Signes, Raffaele Cerutti, Anna S Dickson, Cristiane Benincá, Elizabeth C Hinchy, Daniele Ghezzi, Rosalba Carrozzo, Enrico Bertini, Michael P Murphy, James A Nathan, Carlo Viscomi, Erika Fernandez‐Vizarra, Massimo Zeviani

Get full text

A novel class of mitochondria-targeted soft electrophiles modifies mitochondrial proteins and inhibits mitochondrial metabolism in breast cancer cells through redox mechanisms. by Praveen K Vayalil, Joo-Yeun Oh, Fen Zhou, Anne R Diers, M Ryan Smith, Hafez Golzarian, Patsy G Oliver, Robin A J Smith, Michael P Murphy, Sadanandan E Velu, Aimee Landar

Get full text

MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes by Alex M. Parker, Jarmon G. Lees, Mitchel Tate, Ren J. Phang, Anida Velagic, Minh Deo, Tayla Bishop, Thomas Krieg, Michael P. Murphy, Shiang Y. Lim, Miles J. De Blasio, Rebecca H. Ritchie

Get full text

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice by Mariana J Kaplan, Karen A Fortner, Luz P Blanco, Iwona Buskiewicz, Nick Huang, Pamela C Gibson, Deborah L Cook, Hege L Pedersen, Peter S T Yuen, Michael P Murphy, Ralph C Budd, ANDRAS PERL

Get full text

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism. by Rida Mourtada, Sonali B Fonseca, Simon P Wisnovsky, Mark P Pereira, Xiaoming Wang, Rose Hurren, Jeremy Parfitt, Lesley Larsen, Robin A J Smith, Michael P Murphy, Aaron D Schimmer, Shana O Kelley

Get full text

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition. by Pau B Esparza-Moltó, Inés Romero-Carramiñana, Cristina Núñez de Arenas, Marta P Pereira, Noelia Blanco, Beatriz Pardo, Georgina R Bates, Carla Sánchez-Castillo, Rafael Artuch, Michael P Murphy, José A Esteban, José M Cuezva

Get full text

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. by Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne M Toivonen, Michael P Murphy, Janet Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge

Get full text

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition by Alicia Garcia-Gimenez, Jonathan E. Ditcham, Dhoyazan M. A. Azazi, George Giotopoulos, Ryan Asby, Eshwar Meduri, Jaana Bagri, Nathalie Sakakini, Cecile K. Lopez, Nisha Narayan, Tumas Beinortas, Shuchi Agrawal-Singh, Kent Fung, David O’Connor, Marc R. Mansour, Husam B. R. Alabed, Benjamin Jenkins, Albert Koulman, Michael P. Murphy, Sarah J. Horton, Brian J. P. Huntly, Simon E. Richardson

Get full text

Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice by Cheukyau Luk, Katherine I. Bridge, Nele Warmke, Katie J. Simmons, Michael Drozd, Amy Moran, Amanda D. V. MacCannell, Chew W. Cheng, Sam Straw, Jason L. Scragg, Jessica Smith, Claire H. Ozber, Chloe G. Wilkinson, Anna Skromna, Natallia Makava, Hiran A. Prag, T. Simon Futers, Oliver I. Brown, Alexander-Francisco Bruns, Andrew MN Walker, Nicole T. Watt, Romana Mughal, Kathryn J. Griffin, Nadira Y. Yuldasheva, Sunti Limumpornpetch, Hema Viswambharan, Piruthivi Sukumar, David J. Beech, Antonio Vidal-Puig, Klaus K. Witte, Michael P. Murphy, Richard C. Hartley, Stephen B. Wheatcroft, Richard M. Cubbon, Lee D. Roberts, Mark T. Kearney, Natalie J. Haywood

Get full text