518 Modeling of cancer mutations found in pediatric DICER1 syndrome informs novel therapeutic targeting strategies by David Jee, Seungjae Lee, Dapeng Yang, Robert Rickert, Renfu Shang, Danwei Huangfu, Eric C. Lai

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Regulatory logic of endogenous RNAi in silencing de novo genomic conflicts. by Jeffrey Vedanayagam, Ching-Jung Lin, Ranjith Papareddy, Michael Nodine, Alex S Flynt, Jiayu Wen, Eric C Lai

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ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. by Seungjae Lee, Lu Wei, Binglong Zhang, Raeann Goering, Sonali Majumdar, Jiayu Wen, J Matthew Taliaferro, Eric C Lai

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Double trouble: two retrotransposons triggered a cascade of invasions in Drosophila species within the last 50 years by Almorò Scarpa, Riccardo Pianezza, Hannah R. Gellert, Anna Haider, Bernard Y. Kim, Eric C. Lai, Robert Kofler, Sarah Signor

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Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans. by Jeffrey Vedanayagam, Marion Herbette, Holly Mudgett, Ching-Jung Lin, Chun-Ming Lai, Caitlin McDonough-Goldstein, Stephen Dorus, Benjamin Loppin, Colin Meiklejohn, Raphaëlle Dubruille, Eric C Lai

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Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects. by Daniel Hain, Brian R Bettencourt, Katsutomo Okamura, Tibor Csorba, Wibke Meyer, Zhigang Jin, Jason Biggerstaff, Haruhiko Siomi, Gyorgy Hutvagner, Eric C Lai, Michael Welte, H-Arno J Müller

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