Effectiveness of analgesic ear drops as add-on treatment to oral analgesics in children with acute otitis media: study protocol of the OPTIMA pragmatic randomised controlled trial by Paul Little, Alastair D Hay, Lucy Yardley, G Ardine de Wit, Nicolaas P A Zuithoff, Sibyl Anthierens, Roderick P Venekamp, Anne G M Schilder, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Joline L H de Sévaux

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Topical or oral antibiotics for children with acute otitis media presenting with ear discharge: study protocol of a randomised controlled non-inferiority trial by Anne GM Schilder, Alastair D Hay, Marc J M Bonten, Michael V Moore, G Ardine de Wit, Debby Bogaert, Roderick P Venekamp, Roger A M J Damoiseaux, Elisabeth A M Sanders, Saskia Hullegie, Thijs M A van Dongen, Sanne Mulder, Willem van Schaik

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