Humatch - fast, gene-specific joint humanisation of antibody heavy and light chains by Lewis Chinery, Jeliazko R. Jeliazkov, Charlotte M. Deane

Get full text

Revisiting date and party hubs: novel approaches to role assignment in protein interaction networks. by Sumeet Agarwal, Charlotte M Deane, Mason A Porter, Nick S Jones

Get full text

Large scale paired antibody language models. by Henry Kenlay, Frédéric A Dreyer, Aleksandr Kovaltsuk, Dom Miketa, Douglas Pires, Charlotte M Deane

Get full text

Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data by Ísak Valsson, Matthew T. Warren, Charlotte M. Deane, Aniket Magarkar, Garrett M. Morris, Philip C. Biggin

Get full text

Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies. by Sarah A Robinson, Matthew I J Raybould, Constantin Schneider, Wing Ki Wong, Claire Marks, Charlotte M Deane

Get full text

T-cell receptor structures and predictive models reveal comparable alpha and beta chain structural diversity despite differing genetic complexity by Nele P. Quast, Brennan Abanades, Bora Guloglu, Vijaykumar Karuppiah, Stephen Harper, Matthew I. J. Raybould, Charlotte M. Deane

Get full text

Quantifying conformational changes in the TCR:pMHC-I binding interface by Benjamin McMaster, Benjamin McMaster, Christopher J. Thorpe, Christopher J. Thorpe, Jamie Rossjohn, Jamie Rossjohn, Charlotte M. Deane, Hashem Koohy

Get full text

Challenges in antibody structure prediction by Monica L. Fernández-Quintero, Janik Kokot, Franz Waibl, Anna-Lena M. Fischer, Patrick K. Quoika, Charlotte M. Deane, Klaus R. Liedl

Get full text

Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Matteo P. Ferla, Rubén Sánchez-García, Rachael E. Skyner, Stefan Gahbauer, Jenny C. Taylor, Frank von Delft, Brian D. Marsden, Charlotte M. Deane

Get full text

A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs by Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen, Paolo Arosio

Get full text

Publisher Correction: The molecular reach of antibodies crucially underpins their viral neutralisation capacity by Anna Huhn, Daniel Nissley, Daniel B. Wilson, Mikhail A. Kutuzov, Robert Donat, Tiong Kit Tan, Ying Zhang, Michael I. Barton, Chang Liu, Wanwisa Dejnirattisai, Piyada Supasa, Juthathip Mongkolsapaya, Alain Townsend, William James, Gavin Screaton, P. Anton van der Merwe, Charlotte M. Deane, Samuel A. Isaacson, Omer Dushek

Get full text

Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations by Frédéric A. Dreyer, Constantin Schneider, Aleksandr Kovaltsuk, Daniel Cutting, Matthew J. Byrne, Daniel A. Nissley, Henry Kenlay, Claire Marks, David Errington, Richard J. Gildea, David Damerell, Pedro Tizei, Wilawan Bunjobpol, John F. Darby, Ieva Drulyte, Daniel L. Hurdiss, Sachin Surade, Newton Wahome, Douglas E.V. Pires, Charlotte M. Deane

Get full text