The Drosophila hematopoietic niche assembles through collective cell migration controlled by neighbor tissues and Slit-Robo signaling by Kara A Nelson, Kari F Lenhart, Lauren Anllo, Stephen DiNardo

“…Consistency of niche position suggests that placement is important for niche function. However, the complexity of most niches has precluded a thorough understanding of how their proper placement is established. …”
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CRABP1 Signalosomes in Non-Canonical Actions of Retinoic Acid—Maintaining Health and Preventing Thyroid Dysfunction in Aging by Jennifer Nhieu, Fatimah Najjar, Li-Na Wei

“…RA also elicits rapid, RAR-independent (noncanonical) activities mediated by Cellular RA Binding Protein 1 (CRABP1) to modulate cytosolic signaling. CRABP1 functions by forming protein complexes, named CRABP1 signalosomes, to modulate signal propagation in a cell type-specific manner. …”
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RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation by Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo

“…Here, we map the genome‐wide occupancy of RNAPII and Polycomb from pluripotent ESCs to non‐dividing functional dopaminergic neurons. We find that poised RNAPII complexes are ubiquitously present at Polycomb‐repressed genes at all stages of neuronal differentiation. …”
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Well Performance from Numerical Methods to Machine Learning Approach: Applications in Multiple Fractured Shale Reservoirs by Kailei Liu, Boyue Xu, Changjea Kim, Jing Fu

“…Horizontal well fracturing technology is widely used in unconventional reservoirs such as tight or shale oil and gas reservoirs. Meanwhile, the potential of enhanced oil recovery (EOR) methods including huff-n-puff miscible gas injection are used to further increase oil recovery in unconventional reservoirs. …”
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Duplex γ/α-phase evolution of biocompatible high-nitrogen stainless steel in additive manufacturing by Yufeng Tao, Liansheng Lin, Xudong Ren, Xuejiao Wang, Xia Cao, Yunxia Ye, Erjin Zhang, Heng Gu, Zijie Dai

“…Artificial tunability of microstructured high-nitrogen γ/α duplex-phase at tight topological control promises transformative opportunities not possessed by individual ferrite or austenitic phase, allowing pre-programming mechanics (density, strength, hardness, and tensile properties) for next-generation industrial or implantable biomedical uses requiring complex geometries and multi-functions.…”
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Thick-panel origami structures forming seamless surfaces by Rui Peng, Gregory S. Chirikjian

“…Existing methods often introduce structural complexities or fail to ensure seamless surfaces, limiting their practicality. …”
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Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas by Ye Ju, Chunyue Ma, Ling Ding, Mingyue Shi, Xia Wang, Dongbei Wu, Qing Wu, Xingjun Qin, Qigang Wang

“…Abstract Penetrating orocutaneous or oropharyngeal fistulas (POFs), severe complications following unsuccessful oral or oropharyngeal reconstruction, remain complex clinical challenges due to lack of supportive tissue, contamination with saliva and chewed food, and dynamic oral environment. …”
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Integrated biomimetic bioprinting of perichondrium with cartilage for auricle reconstruction by Litao Jia, Siyu Liu, Luosha Gu, Xiaomin Liu, Kexin Sun, Feiyang Chu, Jinshi Zeng, Wenshuai Liu, Haiyue Jiang, Xia Liu

“…Simulating the anatomical structure of the native auricle designs a sandwich construction model containing bilateral perichondrium and intermediate cartilage, employing a photocrosslinkable acellular cartilage matrix and gelatin bionics matrix microenvironment, applying co-cultured auricular chondrocytes and adipose-derived stem cells creates functional cell populations, designing hatch patterns imitates microscopic arrangement structures, utilizing sacrificial materials forms interlaminar network traffic to enhance the tight connection between layers, and finally, assessing the regenerative quality of the constructs explores their feasibility and stability. …”
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Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans by Yixuan Jiang, Ying Liang, Fujie Zhao, Zhenguo Lu, Siyu Wang, Yao Meng, Zhanxiang Liu, Jing Zhang, Youbao Zhao

“…Rtf1 is generally considered to be a subunit of the Paf1 complex (Paf1C), which is a multifunctional protein complex involved in histone modification and RNA biosynthesis at multiple stages. …”
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Optimal estimates of trace distance between bosonic Gaussian states and applications to learning by Lennart Bittel, Francesco Anna Mele, Antonio Anna Mele, Salvatore Tirone, Ludovico Lami

“…In this work, we fully resolve this question by demonstrating that if the first and second moments are known up to an error $\varepsilon$, the trace distance error on the state also scales as $\varepsilon$, and this functional dependence is optimal. To prove this, we establish tight bounds on the trace distance between two Gaussian states in terms of the norm distance of their first and second moments. …”
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In silico evaluation of missense SNPs in cancer-associated Cystatin A protein and their potential to disrupt Cathepsin B interaction by Shafaat Hossain, Omar Hamza Bin Manjur, Mst Sharmin Sultana Shimu, Tamanna Sultana, Mustafizur Rahman Naim, Shahariar Siddique, Abdullah Al Mamun, Md Miftaur Rahman, Md Abu Saleh, Md Rakibul Hasan, Tania Rahman

“…Cystatin A (CSTA) functions as a cysteine protease inhibitor by forming tight complexes with the cathepsins. …”
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Profiling of rhizosphere-associated microbial communities in North Alabama soils infested with varied levels of reniform nematodes by Sowndarya Karapareddy, Varsha C. Anche, Sowjanya R. Tamatamu, Madhusudhana R. Janga, Kathy Lawrence, Leopold M. Nyochembeng, Antonette Todd, Lloyd T. Walker, Venkateswara R. Sripathi

“…IntroductionPlant roots, nematodes, and soil microorganisms have a complex interaction in the rhizosphere by exchanging or communicating through biomolecules or chemicals or signals. …”
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Surface protonation amplifies carbon nitride nanosheet-induced phospholipid extraction: Mechanistic insights into enhanced cytotoxicity by Yiping Feng, Jiayong Lao, Jingchuan Xue

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Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer’s disease by Simone M. Crivelli, Aisylu Gaifullina, Jean-Yves Chatton

“…The brain’s high demand for energy necessitates tightly regulated metabolic pathways to sustain physiological activity. …”
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Reconstruction of Tissue-Specific Metabolic Networks Using CORDA. by André Schultz, Amina A Qutub

“…Human metabolism involves thousands of reactions and metabolites. To interpret this complexity, computational modeling becomes an essential experimental tool. …”
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…Summary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. …”
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Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment by Dong He, Wen Zeng, Yi Wang, Yifan Xing, Kang Xiong, Nan Su, Chong Zhang, Yuan Lu, Xinhui Xing

“…Ulcerative colitis (UC) is an incurable and highly complex digestive disease affecting millions of people worldwide. …”
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ECMO-assisted bilateral uniportal thoracoscopic carinal resection and reconstruction: a case report by Bin Wu, Yinliang Sheng, Zhenyang Geng, Yiming Xu, Xueyuan Fan, Ping Yuan, Feng Li, Yu Qi

“…The patient’s postoperative course was uneventful, and she was discharged on postoperative day 4 with satisfactory respiratory function and no major complications. Conclusions This case demonstrates the feasibility and potential benefits of combining ECMO support with uniportal VATS for complex carinal surgeries. …”
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Alternative Splicing in Tumorigenesis and Cancer Therapy by Huiping Chen, Jingqun Tang, Juanjuan Xiang

“…Alternative splicing (AS) is a pivotal post-transcriptional mechanism that expands the functional diversity of the proteome by enabling a single gene to generate multiple mRNA and protein isoforms. …”
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Static Clathrin Assemblies at the Peripheral Vacuole-Plasma Membrane Interface of the Parasitic Protozoan Giardia lamblia. by Jon Paulin Zumthor, Lenka Cernikova, Samuel Rout, Andres Kaech, Carmen Faso, Adrian B Hehl

“…Here, we investigated the molecular consequences of these adaptations on the Giardia endocytic machinery and membrane coat complexes. Despite the absence of canonical clathrin coated vesicles in electron microscopy, Giardia possesses conserved PV-associated clathrin heavy chain (GlCHC), dynamin-related protein (GlDRP), and assembly polypeptide complex 2 (AP2) subunits, suggesting a novel function for GlCHC and its adaptors. …”
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