The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication. by Erika Shor, Christopher L Warren, Joshua Tietjen, Zhonggang Hou, Ulrika Müller, Ilaria Alborelli, Florence H Gohard, Adrian I Yemm, Lev Borisov, James R Broach, Michael Weinreich, Conrad A Nieduszynski, Aseem Z Ansari, Catherine A Fox

“…Since HMR-E possessed a unique non-replication function, we reasoned that other tight sites might reveal novel functions for ORC on chromosomes. …”
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Effect of Probiotics Complex on Improving Antibiotic-associated Diarrhea in Mice by Liyi LU, Yecheng GAO, Junlong CHEN, Yajuan GUO, Hualin LIU, Chang CHEN, Xinliang MAO

“…Furthermore, the administration of probiotics complex notably up-regulated the mRNA expression levels of intestinal tight junction proteins ZO-1 and occludin (P<0.05). …”
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Structural and functional insights into the pilotin-secretin complex of the type II secretion system. by Shuang Gu, Saima Rehman, Xiaohui Wang, Vladimir E Shevchik, Richard W Pickersgill

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Comparison between contra-incision combined with high loose-tight thread and traditional incision-thread-drawing procedure for high complex anal fistula by Peng Jue, Peng Yunhua, Liu Suzhi, Chen Tian, Fang Chenyang, Yang Wei

“…[Conclusion] Compared with traditional incision-thread-drawing procedure, contra-incision combined with high loose-tight thread for high complex anal fistula can achieve comparable effectiveness and recurrence rate and shows benefits of shorter time to wound healing, less postoperative anal distension, less wound pain, and better anal function.…”
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The Melilla-Nador cross-border urban complex by Gabino Ponce Herrero, Pablo Martí Ciriquián

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Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21. by Veerle De Wever, David C Lloyd, Isha Nasa, Mhairi Nimick, Laura Trinkle-Mulcahy, Robert Gourlay, Nick Morrice, Greg B G Moorhead

“…High throughput, mass-spectrometry based studies have limited sensitivity for the detection of low-abundance and transient complexes, a typical feature of many protein phosphatase complexes. …”
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Complex Medium-Chain Triglycerides Mitigate Porcine Epidemic Diarrhea Virus Infection in Piglets by Enhancing Anti-Inflammation, Antioxidation, and Intestinal Barrier Function by Tingting Hu, Yunhao Liu, Sihui Gao, Xiaonan Zhao, Huangzuo Cheng, Youjun Hu, Huaqiao Tang, Zhiwen Xu, Chunlin Fang

“…Further investigation is needed to assess whether complex medium-chain triglycerides (CMCTs), composed of glyceryl tricaprylate/caprate (GTCC) and GML, offer an efficient anti-PEDV activity. …”
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TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis by Jingshu Tang, Yuying Kang, Qiuyu Chen, Baodan Zhang, Nianying Shang, Jiaqi Lan, Lei Wu, Ying Peng

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A genetic algorithm to generate maximally orthogonal frames in complex space by Sebastián Roca-Jerat, Juan Román-Roche

“…Then, we discuss the relation between different energy functions and well-known frame varieties such as tight and Grassmannian frames and complex projective p -designs. …”
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A novel lutein-stevioside complex inhibits DSS-induced colitis by Yangyang Dong, Mengdi Hao, Yayuan Xu, Lei Feng, Dajing Li, Yunhe Lian, Di Wu, Zhuqing Dai

“…We previously prepared a highly water-soluble lutein-stevioside (LUT-STE) complex, which significantly improved the bioavailability of lutein. …”
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Intersegmental eye-head-body interactions during complex whole body movements. by Christoph von Laßberg, Karl A Beykirch, Betty J Mohler, Heinrich H Bülthoff

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Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex by María Fernández-Casañas, Eleftheria Karanika, Umit Aliyaskarova, Tomisin Olukoga, Alex D. Herbert, Antony W. Oliver, Matthew Day, Adrijana Crncec, Kok-Lung Chan

“…Inactivating the BLM-TOP3A interaction compromises the UFB-binding complex functions and prevents centromere destruction. …”
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USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination by Derek L. Bolhuis, Dalia Fleifel, Thomas Bonacci, Xianxi Wang, Brandon L. Mouery, Jeanette Gowen Cook, Nicholas G. Brown, Michael J. Emanuele

“…Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability. …”
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Bi-allelic variants in WDR47 cause a complex neurodevelopmental syndrome by Efil Bayam, Peggy Tilly, Stephan C Collins, José Rivera Alvarez, Meghna Kannan, Lucile Tonneau, Elena Brivio, Bruno Rinaldi, Romain Lecat, Noémie Schwaller, Ludovica Cotellessa, Sateesh Maddirevula, Fabiola Monteiro, Carlos M Guardia, João Paulo Kitajima, Fernando Kok, Mitsuhiro Kato, Ahlam A A Hamed, Mustafa A Salih, Saeed Al Tala, Mais O Hashem, Hiroko Tada, Hirotomo Saitsu, Mariano Stabile, Paolo Giacobini, Sylvie Friant, Zafer Yüksel, Mitsuko Nakashima, Fowzan S Alkuraya, Binnaz Yalcin, Juliette D Godin

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TelAP2 links TelAP1 to the telomere complex in Trypanosoma brucei by Nadine Weisert, Verena Majewski, Laura Hartleb, Katarina Luko, Liudmyla Lototska, Nils Christian Krapoth, Helle D. Ulrich, Christian J. Janzen, Falk Butter

“…Three functional homologs of mammalian telomere complex proteins have been characterized thus far, and novel telomere-interacting proteins, such as telomere-associated protein 1 (TelAP1), have recently been identified. …”
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βTrCP facilitates MRN complex localization on chromatin to enhance DNA repair by Alejandro Belmonte-Fernández, Joaquín Herrero-Ruíz, Carmen Sáez, Miguel Á. Japón, Mar Mora-Santos, Francisco Romero

“…Upon detecting DNA breaks, this complex triggers a cascade of signaling events that regulate both cell cycle arrest and DNA repair. …”
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ASPP2 links the apical lateral polarity complex to the regulation of YAP activity in epithelial cells. by Christophe Royer, Sofia Koch, Xiao Qin, Jaroslav Zak, Ludovico Buti, Ewa Dudziec, Shan Zhong, Indrika Ratnayaka, Shankar Srinivas, Xin Lu

“…Here we report that the tumour suppressor ASPP2 forms an apical-lateral polarity complex at the level of tight junctions in polarised epithelial cells, acting as a scaffold for protein phosphatase 1 (PP1) and junctional YAP via dedicated binding domains. …”
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Deep learning-driven automated mitochondrial segmentation for analysis of complex transmission electron microscopy images by Chan Jang, Hojun Lee, Jaejun Yoo, Haejin Yoon

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Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome by Xin Yong, Guowen Jia, Qin Yang, Chunzhuang Zhou, Sitao Zhang, Huaqing Deng, Daniel D. Billadeau, Zhaoming Su, Da Jia

“…The BLOC-3 complex consists of one copy of HPS1 and HPS4, which tightly associate with each other via their longin domains (LD1 and LD3). …”
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A Complex Network of Obesity-Risk Genes Revealed by Systematic Bioinformatics and Single-Cell Transcriptomic Analyses by Yuenan Liu, Haolin Yuan, Junhui Hu, Xu Xu, Shankai Yin, Yiming Hu, Feng Liu

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