The impact of T cells on immune-related liver diseases: an overview by Yuzo Koda, Ryosuke Kasuga, Nobuhito Taniki, Takanori Kanai, Nobuhiro Nakamoto

“…Liver diseases are closely associated with the immune system. Disruption of the tightly regulated balance between immune activation and tolerance induction leads to the development and worsening of immune-related liver diseases. …”
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Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development by Divyesh Joshi, Preeti Jindal, Ronak K Shetty, Maneesha S Inamdar

“…The transforming growth factor β (TGFβ) signaling pathway is critical for survival, proliferation, and cell migration, and is tightly regulated during cardiovascular development. …”
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Crosstalk between metabolism and epigenetics during macrophage polarization by Kangling Zhang, Chinnaswamy Jagannath

“…Abstract Macrophage polarization is a dynamic process driven by a complex interplay of cytokine signaling, metabolism, and epigenetic modifications mediated by pathogens. …”
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Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets by Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun

“…Conclusions: These findings highlight the complex regulatory mechanisms underlying retinal responses to bTOI, involving neuroinflammation, oxidative stress, and disruptions in melatonin synthesis and photoreceptor cell functions. …”
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Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care by Alina-Georgiana Cristea (Hohotă), Elena-Lăcrămioara Lisă, Simona Iacob (Ciobotaru), Ionut Dragostin, Claudia Simona Ștefan, Iuliu Fulga, Andra Monica Anghel (Ștefan), Maria Dragan, Ionela Daniela Morariu, Oana-Maria Dragostin

“…Wound healing is a complex, tightly regulated process essential for maintaining skin barrier function. …”
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Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells by Akiko Sugimoto-Ishige, Aya Jodo, Takashi Tanaka

“…In this study, we have demonstrated that PDLIM2 forms a ubiquitin ligase complex with Cullin 1, a scaffold protein, providing a platform consisting of complex and Skp1, an adaptor protein. …”
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Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency by Shao Yang, Yawei Sun, Wei Luo, Xiaofeng Zhou, Xiao Gu, Wenzhe Zhang, Huashan Zhu, Wenjia Wu, Xueying Wu, Mengru Yu, Shan Wang

“…Dominant follicles play a vital role in ovarian endocrine and reproductive function. Zona pellucida glycoprotein 3 (ZP3) is a specific component of the zona pellucida around the oocyte and is tightly associated with the dominant follicle. …”
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Ca2+ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: a review by Yoshiaki Suzuki, Wayne R. Giles, Gerald W. Zamponi, Rubii Kondo, Yuji Imaizumi, Hisao Yamamura

“…The subsets of these ion channels involved in Ca2+ signaling often form molecular complexes with intracellular molecules via scaffolding proteins. …”
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Cleavage site heterogeneity at the pre-mRNA 3′-untranslated region regulates gene expression in oxidative stress response by Feba Shaji, Jamshaid Ali, Rakesh S. Laishram

“…The endonucleolytic cleavage step of the eukaryotic mRNA 3′-end processing is considered imprecise, which leads to heterogeneity of cleavage site (CS) with hitherto unknown function. Contrary to popular belief, we show that this imprecision in the cleavage is tightly regulated, resulting in the CS heterogeneity (CSH) that controls gene expression in antioxidant response. …”
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Development and assessment of an intestinal tri-cellular model to investigate the pro/anti-inflammatory potential of digested foods by Marina Ramal-Sanchez, Chiara Bravo-Trippetta, Veronica D’Antonio, Elena Corvaglia, Angela A. M. Kämpfer, Roel P. F. Schins, Mauro Serafini, Donato Angelino

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Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability by Alexandra Berroyer, Albino Bacolla, John A. Tainer, Nayun Kim

“…Interestingly, Top1 binds tightly to G4 struc-tures, and its inhibition or depletion can cause elevated instability at these ge-nomic loci. …”
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Expression of LTR and LINE1 transposable elements defines atypical teratoid/rhabdoid tumor subtypes by Martin V. Hamann, Shweta Godbole, Maisha Adiba, Sabrina M. Leddy, Jelena Navolić, Ghazaleh Tabatabai, Daniel J. Merk, Ulrike C. Lange, Julia E. Neumann

“…The sole recurrent biallelic loss-of-function mutation in SMARCB1 in ATRTs, a core component of the SWI/SNF chromatin remodeling complex, raises the question of how TE transcription contributes to ATRT development. …”
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RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation by Alejandro Rosell, Agata Adelajda Krygowska, Marta Alcón Pérez, Cristina Cuesta, Mathieu-Benoit Voisin, Juan de Paz, Héctor Sanz-Fraile, Vinothini Rajeeve, Ana Carreras-González, Alberto Berral-González, Ottilie Swinyard, Enrique Gabandé-Rodríguez, Julian Downward, Jordi Alcaraz, Juan Anguita, Carmen García-Macías, Javier De Las Rivas, Pedro R Cutillas, Esther Castellano Sanchez

“…Macrophages are crucial in the body’s inflammatory response, with tightly regulated functions for optimal immune system performance. …”
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Synergistic activation of the human phosphate exporter XPR1 by KIDINS220 and inositol pyrophosphate by Peng Zuo, Weize Wang, Zonglin Dai, Jiye Zheng, Shang Yu, Guangxi Wang, Yue Yin, Ling Liang, Yuxin Yin

“…Here we report cryo-EM structures of the human XPR1-KIDINS220 complex in substrate-free closed and substrate-bound outward-open states, as well as an XPR1 mutant in a substrate-bound inward-facing state. …”
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Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches by Cristina Uța, Alexandru Tîrziu, Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Marius Georgescu, Laura Haidar, Carmen Panaitescu

“…Recurrent pregnancy loss (RPL) is a complex early pregnancy complication affecting 1–2% of couples and is often linked to immune dysfunction. …”
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An integrated structural and biophysical approach to study carbon metabolism in Mycobacterium tuberculosis by Evelyn Y.-W. Huang, Francis Kuang, Haozhe Wu, Chai Xin Yu, Xiaoxu Chen, Glenda Vasku, Le Thao Anh Nguyen, Katherine J. Jeppe, Anna K. Coussens, Brooke X.C. Kwai, Ivanhoe K.H. Leung

“…Many of these enzymes are tightly regulated by feedback mechanisms. To fully understand their roles and modulation, it is crucial to investigate the relationship between their structure, catalytic mechanism, and function. …”
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Effects of Pueraria montana and Melastoma dodecandrum Intercropping on Soil and Tea Plant Growth in Terraced Tea Gardens: A Sustainable Agricultural Practice by Lingshan Shi, Dongliang Li, Shuaibo Shao, Fajie Feng, Qisong Li, Fanfan Zeng, Lingyuan Shi, Jianming Zhang, Yongcong Hong, Pumo Cai

“…This study investigated the complex interactions between soil microorganisms, soil, and tea trees in two intercropping systems: tea/Pueraria montana var. culaishanensis (HWT) and tea/Melastoma dodecandrum Lour. …”
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A controllable photoresponsive potassium transporter by Zhongyan Li, Lin Yuan, Wenju Chang, Junqiu Liu, Jie Shen, Huaqiang Zeng

“…We report here a controllable, photoresponsive, ion-transporting carrier, achieving controllability through a photoregulated β-cyclodextrin (β-CD)-azobenzene host-guest complex. In this complex, a lipid-anchored β-CD serves as the launch base, tightly immobilizing through host-guest interactions the otherwise freely moving trans-transporter derived from a crown ether-modified trans-azobenzene motif, but rapidly releasing most of it upon 365 nm UV irradiation that converts transporter to its cis-configuration. …”
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Robust Symbol Detection in Large-Scale Overloaded NOMA Systems by Hiroki Iimori, Giuseppe Thadeu Freitas De Abreu, Takanori Hara, Koji Ishibashi, Razvan-Andrei Stoica, David Gonzalez G., Osvaldo Gonsa

“…</italic>, 2020), the method is not relaxed into the <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-norm, but rather approximated with a continuous and asymptotically exact expression without resorting to parallel interference cancellation (PIC). The objective function of the resulting formulation is thus a sum of concave-over-convex ratios, which is then tightly convexified via the quadratic transform (QT), such that its solution can be obtained via the iteration of a simple closed-form expression that closely resembles that of the classic zero-forcing (ZF) receiver, making the method particularly suitable to large-scale set-ups. …”
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CCR3 deficiency shifts adaptive to innate-driven immunity in asthma by Susanne Krammer, RPh, Zuqin Yang, PhD, Hannah Mitländer, MD, Janina C. Grund, MD, Carol I. Geppert, MD, Ralf J. Rieker, MD, Sabine Zirlik, MD, Susetta Finotto, PhD

“…Background: Because of repeated contact with airborne allergens, patients suffering from allergic asthma experience acute asthma attacks, characterized by shortness of breath, chest tightness, and coughing. The underlying immune response is highly complex and involves various immune cells. …”
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