Surface protonation amplifies carbon nitride nanosheet-induced phospholipid extraction: Mechanistic insights into enhanced cytotoxicity by Yiping Feng, Jiayong Lao, Jingchuan Xue

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Reconstruction of Tissue-Specific Metabolic Networks Using CORDA. by André Schultz, Amina A Qutub

“…Human metabolism involves thousands of reactions and metabolites. To interpret this complexity, computational modeling becomes an essential experimental tool. …”
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TRF1 and TRF2 form distinct shelterin subcomplexes at telomeres by Tomáš Janovič, Gloria I. Perez, Greta Boelting, Jens C. Schmidt

“…Summary: The shelterin complex protects chromosome ends from aberrant DNA repair and regulates telomerase access to telomeres. …”
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ECMO-assisted bilateral uniportal thoracoscopic carinal resection and reconstruction: a case report by Bin Wu, Yinliang Sheng, Zhenyang Geng, Yiming Xu, Xueyuan Fan, Ping Yuan, Feng Li, Yu Qi

“…The patient’s postoperative course was uneventful, and she was discharged on postoperative day 4 with satisfactory respiratory function and no major complications. Conclusions This case demonstrates the feasibility and potential benefits of combining ECMO support with uniportal VATS for complex carinal surgeries. …”
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Isolation and characterization of novel peptides from fermented products of Lactobacillus for ulcerative colitis prevention and treatment by Dong He, Wen Zeng, Yi Wang, Yifan Xing, Kang Xiong, Nan Su, Chong Zhang, Yuan Lu, Xinhui Xing

“…Ulcerative colitis (UC) is an incurable and highly complex digestive disease affecting millions of people worldwide. …”
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Alternative Splicing in Tumorigenesis and Cancer Therapy by Huiping Chen, Jingqun Tang, Juanjuan Xiang

“…Alternative splicing (AS) is a pivotal post-transcriptional mechanism that expands the functional diversity of the proteome by enabling a single gene to generate multiple mRNA and protein isoforms. …”
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Update on NKCC2 regulation in the thick ascending limb (TAL) by membrane trafficking, phosphorylation, and protein-protein interactions by Dipak Maskey, Dipak Maskey, Jessica Granados Pineda, Jessica Granados Pineda, Pablo A. Ortiz, Pablo A. Ortiz

“…Here, we update the latest molecular mechanisms and players that control NKCC2 function, which gives an increasingly complex picture of NKKC2 regulation in the apical membrane of the TAL.Recent FindingsProtein-protein interactions are required as a regulatory mechanism in many cellular processes. …”
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Revolutionizing Implantation Studies: Uterine-Specific Models and Advanced Technologies by Shu-Yun Li, Francesco John DeMayo

“…Implantation is a complex and tightly regulated process essential for the establishment of pregnancy. …”
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Identifying the effectiveness of face mask in a large population with a network-based fluid model. by Akshay Anand, Kourosh Shoele

“…The study also elucidates the complex role of nose clips in improving sealing efficacy for tightly fitted masks and redirecting leaked flow in typical imperfect facemasks. …”
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Cell-specific genetic expression profile of antennal glia in Drosophila reveals candidate genes in neuron-glia interactions by Ana Castañeda-Sampedro, Esther Alcorta, Carolina Gomez-Diaz

“…Additionally, similarities between the molecular signatures of peripheral glia in Drosophila and vertebrates highlight the utility of model organisms in elucidating glial cell functions in complex systems.…”
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The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severit... by Elizabeth M. Ortega Rocha, Paul Hernández-Herrera, Sofia V. de los Santos- Carmona, Saraí G De León-Rodríguez, Ángel Juárez-Flores, Vadim Pérez-Koldenkova, Octavio Castro-Escamilla, Samira Muñoz-Cruz, Alicia Lemini-López, Laura C. Bonifaz

“…Our findings emphasize the complex interplay between epidermal barrier distribution, SEB localization, and functional CD4 TCRvβ17 cells in psoriatic skin, highlighting their potential in patient stratification in association with the severity of the disease.…”
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The Centriole Stability Assay: A Method to Investigate Mechanisms Involved in the Maintenance of the Centrosome Structure in Drosophila Cultured Cells by Mariana Lince-Faria, Ana Ferreira-Silva, Ana Pimenta-Marques

“…Centrosome numbers are tightly regulated, typically duplicating once per cell cycle, during the S phase. …”
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Integrating particle tracking with computational fluid dynamics to assess haemodynamic perturbation by coronary artery stents. by Luke Boldock, Amanda Inzoli, Silvia Bonardelli, Sarah Hsiao, Alberto Marzo, Andrew Narracott, Julian Gunn, Gabriele Dubini, Claudio Chiastra, Ian Halliday, Paul D Morris, Paul C Evans, Perrault C M

“…Stents had striking effects on fluid flow streamlines, flow separation or funnelling, and the accumulation of particles at areas of complex geometry that were tightly coupled to stent shape. …”
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Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B-Loop and C-Terminus and p22phox N-Terminus: An Elusive Target by Gábor Csányi, Patrick J. Pagano

“…Although NADPH oxidase 4 (Nox4) is the most abundant Nox isoform in systemic vascular endothelial and smooth muscle cells, its function in the vascular tissue is not entirely known. …”
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The Interplay of Iron and Lipid Homeostasis in Non-Alcoholic Fatty Liver Disease by Clinton J. Kidman, Cyril D.S. Mamotte, Keea R. Inder-Smith, Mark J. Tobin, Mark J. Hackett, Ross M. Graham

“… The liver is essential for numerous metabolic functions and is the primary site of iron storage and regulation in addition to maintaining critical functions in lipid metabolism. …”
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Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation by Wenhan Ju, Shuai Zhao, Danping Li, Jinfu Zhang, Jinfu Zhang, Shan Xiang, Fang Lian

“…The cyclic recruitment of primordial follicles and the preservation of oocyte quality involve complex and tightly regulated biological processes. …”
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A targeted MAVS fusion protein for controlled innate immune activation and antitumor therapy by Muhan Wang, Zhijie Zhang, YouYou Yang, Xiaoyi Peng, Hongping Yin

“…TRIAS-expressing tumor cells exhibited enhanced antitumor activity, likely due to increased cytokine release and upregulated major histocompatibility complex (MHC) expression, enabling tumor cells to function as antigen-presenting cells. …”
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The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. by David S Guttery, Jon K Pittman, Karine Frénal, Benoit Poulin, Leon R McFarlane, Ksenija Slavic, Sally P Wheatley, Dominique Soldati-Favre, Sanjeev Krishna, Rita Tewari, Henry M Staines

“…Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms. These mechanisms are therefore of interest as putative drug targets. …”
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Successful management of severe anaerobic infection inducing mediastinal and subcutaneous emphysema, septic shock, and ARDS: a case report highlighting VV-ECMO and NGS-guided thera... by Haohao Wu, Pin Lan, Kechun Zhou, Xingzhen Wu, Lutao Xie

“…After 7 days of ECMO support and anti-infective treatment, the patient’s oxygenation improved significantly, inflammatory markers decreased, and ECMO was successfully weaned.ConclusionVV-ECMO is of critical value in managing septic shock and ARDS caused by severe anaerobic infections, effectively improving oxygenation and supporting organ function. This case highlights the pivotal role of airway management, VV-ECMO support, and comprehensive therapeutic strategies in the management of complex infectious ARDS, providing valuable insights for similar clinical scenarios.…”
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Case Report: Giant pheochromocytoma complicated by takotsubo syndrome: a case of emergency robot-assisted left adrenalectomy and multidisciplinary management by Jia Miao, Jia Miao, Xuanhan Hu, Xuanhan Hu, Ting Wang, Feng Liu, Dahong Zhang, Haibin Wei

“…This case highlights the successful emergency management of this complex condition, demonstrating the feasibility of robotic adrenalectomy in hemodynamically unstable patients. …”
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