Niemann - Pick C2 regulates steroid hormone secretion and lipid deposition in chicken follicular granulosa cells by Ruihao Yu, Shuo Wei, Felix Kwame Amevor, Liuting Wu, Dan Xu, Zheliang Liu, Kunlong Qi, Yingjie Wang, Gang Shu, Xiaoling Zhao

“…Follicular development is tightly regulated by the coordinated action of multiple hormones and complex gene regulatory networks in granulosa cells, which play a crucial role in egg production and fertility in hens. …”
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Measuring communities’ efficiencies within the global tourism network by He Zhu

“…Abstract Tourist flows between countries shape the global tourism network, with tightly interconnected nations forming distinct communities. …”
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Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder by Itay Tokatly Latzer, Jean-Baptiste Roullet, Wardiya Afshar-Saber, Henry H. C. Lee, Mariarita Bertoldi, Gabrielle E. McGinty, Melissa L. DiBacco, Erland Arning, Melissa Tsuboyama, Alexander Rotenberg, Thomas Opladen, Kathrin Jeltsch, Àngels García-Cazorla, Natalia Juliá-Palacios, K. Michael Gibson, Mustafa Sahin, Phillip L. Pearl

“…Conclusions Findings from the SSADHD Natural History Study converge with iPSC and animal model work focused on a common disorder within our IDDRC, deepening our knowledge of the pathophysiology and longitudinal clinical course of a complex neurodevelopmental disorder. This further enables the identification of biomarkers and changes throughout development that will be essential for upcoming targeted trials of enzyme replacement and gene therapy.…”
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PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease by Purin Charoensuksai, Wei Xu

“…The circadian rhythm, controlled by a complex network of cellular transcription factors, orchestrates behavior and physiology in the vast majority of animals. …”
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The Diversity of Cold Worlds: A Blended-light Binary Straddling the T/Y Transition in Brown Dwarfs by Daniella C. Bardalez Gagliuffi, Jacqueline K. Faherty, Genaro Suárez, Sherelyn Alejandro Merchan, Brianna Lacy, Ben Burningham, Klara Matuszewska, Rocio Kiman, Johanna M. Vos, Austin Rothermich, Jonathan Gagné, Caroline Morley, Melanie J. Rowland, Dan Caselden, Aaron Meisner, Adam C. Schneider, Marc J. Kuchner, Charles A. Beichman, Peter R. Eisenhardt, Christopher R. Gelino, Ehsan Gharib-Nezhad, Eileen C. Gonzales, Federico Marocco, Niall Whiteford, J. Davy Kirkpatrick

“…Carbon disequilibrium chemistry strongly shapes the mid-infrared spectra of these sources, as a complex function of the metallicity and surface gravity. …”
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Proteoglycans in normal physiology and carcinogenesis by A. V. Suhovskih, E. V. Grigorieva

“…An important role in this process belongs to the complex protein-carbohydrate molecules – proteoglycans (PG), which are one of the main component of ECM and cell surface of any tissue and are tightly involved in cell-cell and cell-matrix interactions and signaling. …”
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Enhanced propionate and butyrate metabolism in cecal microbiota contributes to cold-stress adaptation in sheep by Xindong Cheng, Yanping Liang, Kaixi Ji, Mengyu Feng, Xia Du, Dan Jiao, Xiukun Wu, Chongyue Zhong, Haitao Cong, Guo Yang

“…Correlation analysis indicated that butyrate holds a central position in both networks, with Hulunbuir sheep exhibiting a more complex and tightly regulated network involving SCFAs, microbiota, microbial functions, and transcriptomes. …”
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Interactions Between Iron Metabolism and the Endocannabinoid System in Bacterial Infections by Kayle Brenna Dickson, Juan Zhou, Christian Lehmann

“…Iron is a key nutritional requirement for a variety of physiological functions, and its metabolism is tightly controlled under homeostatic conditions. …”
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Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies by Yang Xinyi, Reshetov Igor Vladimirovich, Narasimha M. Beeraka, Allaka Satyavathi, Dinisha Kamble, Vladimir N. Nikolenko, Allaka Naga Lakshmi, Basappa Basappa, Padmanabha Reddy Y, Ruitai Fan, Junqi Liu

“…Abstract Background Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated process predominantly influenced by immune factors. …”
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Quantitative determination of iron (III) in polymaltose haematinic formulations on the Ghanaian market. by Rita Okwampah, Kofi Dzorgbenyuie Bedzra, Oti Kwasi Gyamfi, James Ataki, Foster Kyei, Martin Adarkwah-Yiadom, Edem Sosu, Emmanuel Boateng

“…Iron is an essential element needed by living organisms to enable their bodies to perform a variety of cellular functions and it is tightly regulated in the body systems of living organisms. …”
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Transmission interference microscopy of anterior human eye by Samer Alhaddad, Wajdene Ghouali, Christophe Baudouin, Albert Claude Boccara, Viacheslav Mazlin

“…Specifically, we show that the tightly localized illumination spot at the sclera functions analogously to a closed condenser aperture in conventional microscopy, significantly enhancing interference contrast. …”
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Regulators and Effectors of Arf GTPases in Neutrophils by Jouda Gamara, François Chouinard, Lynn Davis, Fawzi Aoudjit, Sylvain G. Bourgoin

“…G protein-dependent signalling pathways tightly control PMN functions. In this review, we will focus on the small monomeric GTPases of the Arf family and their guanine exchange factors (GEFs) and GTPase activating proteins (GAPs) as components of signalling cascades regulating PMN responses. …”
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The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells. by Jennifer Olt, Philomena Mburu, Stuart L Johnson, Andy Parker, Stephanie Kuhn, Mike Bowl, Walter Marcotti, Steve D M Brown

“…Gelsolin is part of a whirlin scaffolding protein complex at the stereocilia tip, which has been shown to interact with other actin regulatory molecules such as Eps8. …”
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GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans. by Marina Martinez-Garcia, Pedro Robles Naharro, Marnie W Skinner, Kerstin A Baran, Laura I Lascarez-Lagunas, Saravanapriah Nadarajan, Nara Shin, Carlos G Silva-García, Takamune T Saito, Sara Beese-Sims, Brianna N Diaz-Pacheco, Elizaveta Berson, Ana B Castañer, Sarai Pacheco, Enrique Martinez-Perez, Philip W Jordan, Monica P Colaiácovo

“…Delayed homologous chromosome pairing, synaptonemal complex (SC) assembly, and DNA double-strand break repair progression are partially rescued by the expression of human CYTIP in gras-1 mutants, supporting functional conservation. …”
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Socio-economic and ecological aspects of land management in cities by Olga Petrakovska, Mariia Mykhalova

“…Modern technologies progress contributes to more intense and complex technogenic load of the land. The active use of the land in a vertical dimension (not only ground, but also underground and aboveground space) often leads to consequences which are increasingly creating negative social pressures and necessitate the economic and environmental matching. …”
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Versatility of vimentin assemblies: From filaments to biomolecular condensates and back by Dolores Pérez-Sala, Silvia Zorrilla

“…Recent findings have unveiled the importance of low complexity sequence domains in vimentin filament assembly. …”
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Endoscopic Debridement, Ostectomy, Release, and Radiofrequency: A Fully Endoscopic Technique for Treating Recalcitrant Plantar Fasciitis by Walter-Soon-Yaw Wong, M.B.Ch.B., M.R.C.S., Dhivakaran Gengatharan, M.B.B.S., Inderjeet Singh Rikhraj, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Keen Wai Chong, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Wen Xian Png, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth), Eric Wei Liang Cher, M.B.B.S., M.Med.(Ortho), F.R.C.S.Ed.(Orth)

“…Plantar fasciitis (PF), a common cause of heel pain, primarily results from inflammation of the plantar fascia due to excessive strain. Its complex pathophysiology, influenced by various biomechanical factors, has led to the development of diverse surgical techniques. …”
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Challenges in Management of a Post-Traumatic Stiff Elbow – When to Perform Open Arthrolysis: A Case Report by S Adithyaa, K R Tarun Prashanth, M R Thirunthaiyan, R Dorai Kumar, B Sundararaja

“…The elbow joint is particularly susceptible to stiffness due to its highly congruent bony anatomy, relatively confined joint space tightly stabilizing collateral ligament complex, and the close relationship of the surrounding muscles acting as secondary stabilizers. …”
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PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control. by Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann

“…All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. …”
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Loss of ARID1A leads to a cold tumor phenotype via suppression of IFNγ signaling by Pamela M. Watson, Chelsea A. DeVaux, Kevin W. Freeman

“…Our work clarifies that the loss of ARID1A, which tightly associates with MYCN amplification, causes reduced inflammatory signaling. …”
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