Causal Effects Between Blood Pressure Variability and Alzheimer's Disease: A Two‐Sample Mendelian Randomization Study by Pingping Jia, Ziyu Hao, Karen Yiu, Kelvin Tsoi

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Causal Association Between Monounsaturated Fatty Acids and Lung Cancer: A Two‐Sample Mendelian Randomization Study by Shaofeng Zhang, Jia Jiang, Xiping Wu, Jiayi Liu, Wei Lei, Siqin Chen, Yaling Zeng, Xiang Liu, Qiang Xiao

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Causal associations between epigenetic age and thromboembolism: a bi-directional two-sample Mendelian randomization study by Bowen Jin, Yunyan Li, Dingyang Li, Chi Jing, Qunshan Sheng

“…Through Mendelian randomization (MR), this research seeks to assess the causal links between genetically determined epigenetic aging factors and thromboembolism. …”
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Assessing the associations of inflammatory bowel disease and hepatitis B virus infections with two-sample bidirectional mendelian randomization by Ping Han, Chaohui Wang, Yan Qiu

“…This study aimed to determine whether there is a causal association between IBD and CHB using a bidirectional two-sample Mendelian randomization (MR) design. Independent genetic variants were extracted from public genome-wide association studies (GWAS) for CHB (145 cases 351,740 controls) to estimate the causal effects on inflammatory bowel disease (12882 cases 21,770 controls) and its two subtypes: ulcerative colitis (69968 cases 20,464 controls) and Crohn’s disease (5956 cases 14,927 controls). …”
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Causal association between immunoglobulin G N-glycosylation patterns and diabetic complications: two-sample mendelian randomization by Xiaohuan Zhang

“…Abstract Background To elucidate the correlation between immunoglobulin G (IgG) N-glycosylation patterns (IGPs) and diabetes complications, including diabetic nephropathy (DN), diabetic retinopathy (DR) and diabetic maculopathy (DM). We performed a two-sample Mendelian randomization (MR) study. Methods We obtained genome-wide association studies (GWAS) summary statistics related to 77 IGPs and diabetic complications from the MRC Human Genetics Unit and the FinnGen consortium. …”
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The causal effect of gut microbiome on pulmonary artery hypertension based on a two-sample Mendelian randomization study by Detian Jiang, Yuxin Chang, Xiaowen Zhen, Xin Zhao

“…Abstract Background Alterations in gut microbiota composition have been linked to the presence of pulmonary artery hypertension (PAH), but it is unclear whether gut microbiota directly causes PAH. Methods A two-sample Mendelian randomization approach was used to investigate the causal association between gut microbiota and PAH. …”
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Causal relationship between diabetes mellitus and lung cancer: a two-sample Mendelian randomization and mediation analysis by Xiaolin Yu, Binfan Fu, Taizhen Sun, Xu Sun

“…Simultaneously, sensitivity analyses were performed to confirm the lack of horizontal pleiotropy and heterogeneity.ResultsThe two-sample MR analysis illustrated the overall effect of type 1 diabetes mellitus (T1DM) on lung squamous cell carcinoma (LUSC) (OR: 1.040, 95% CI: 1.010–1.072, p = 0.009). …”
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The Causal Effect of Basal Metabolic Rate on Type 2 Diabetes: A Two-Sample Mendelian Randomization Study by Yu Huang, Jianxuan Wen, Xiaofeng Liao, Guiling Chen, Xiang Zeng, Yu Chen

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Causal association between endocrine diseases and lymphoid malignancies explored through two-sample Mendelian randomization analysis by Chenze Zhao, Yu Zhang, Lili Qian, Qing Guo, Ni Zhu

“…Utilizing data from genome-wide association studies, a two-sample Mendelian randomization analysis was performed. …”
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Causal associations of particulate matter 2.5 and cardiovascular disease: A two-sample mendelian randomization study. by Ye Cao, Yi Feng, Nan Xia, Jiancheng Zhang

“…In this study, we used two-sample Mendelian randomization (MR) to examine the causal relationship between PM 2.5 and the risk of CVD.…”
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Causal associations between dietary habits and liver cancer risk: a two-sample Mendelian randomization study by Wen-Hao Hu, Jia-An Sun, Chang Liu

“…Importantly, our two-sample MR investigations indicated no considerable pleiotropy effects in the instrumental variables (IVs). …”
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Tea intake and non-alcoholic fatty liver disease risk: A two-sample Mendelian randomization study by Cuncun Lu, Lixin Ke, Alexios-Fotios A. Mentis, Qiang Zhang, Ziyi Wang, Zhifei Wang

“…Objective: To examine the genetically predicted causal association between tea intake and NAFLD risk using the two-sample Mendelian randomization (MR) method. Methods: Single‐nucleotide polymorphisms (SNPs) strongly associated with tea intake were obtained from a large dataset (N = 447,485) in the UK biobank, and summary‐level genetic data for NAFLD (2,275 cases and 375,002 controls) were collected from the FinnGen consortium. …”
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A two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers by Mikiyas Amare Getu, Xianbin Zhang, Ying Ying, Peng Gong

“…To address this gap, we conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between T1D and 22 site-specific cancers. …”
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Investigation of the causal relationship of saturated fat acids on heart stroke: evidence from two-sample Mendelian randomization by Danial Habibi, Iman Hamraz, Farshad Teymoori, Amir Hesam Saeidian, Hanifeh Mirtavoos-Mahyari, Qumars Kasnavi, Alireza Soleymani Taloubaghi, Homayoon Masoudi, Fereidoun Azizi, Maryam Sadat Daneshpour, Mehdi Hedayati, Mahdi Akbarzadeh, Marjan Mansourian

“…Additionally, we performed a two-sample Mendelian Randomization (TSMR). The odds ratio (OR) with 95% confidence intervals (CIs) was indicated. …”
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Causal relationship between matrix metalloproteinase and pulmonary embolism: a bidirectional two-sample Mendelian randomization study by Xiaowei Gong, Yadong Yuan

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Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study by Zhimin Chen, Zigui Zheng, Bingjing Jiang, Yanfang Xu

“…Objective A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD).Methods The study comprised data from three genome-wide association studies involving individuals of European ancestry. …”
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Corrigendum to “Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study”

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The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study. by Benjamin I Perry, Stephen Burgess, Hannah J Jones, Stan Zammit, Rachel Upthegrove, Amy M Mason, Felix R Day, Claudia Langenberg, Nicholas J Wareham, Peter B Jones, Golam M Khandaker

“…<h4>Methods and findings</h4>We used summary data from genome-wide association studies of mostly European adults from large consortia (Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) featuring up to 108,557 participants; Diabetes Genetics Replication And Meta-analysis (DIAGRAM) featuring up to 435,387 participants; Global Lipids Genetics Consortium (GLGC) featuring up to 173,082 participants; Genetic Investigation of Anthropometric Traits (GIANT) featuring up to 339,224 participants; Psychiatric Genomics Consortium (PGC) featuring up to 105,318 participants; and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium featuring up to 204,402 participants). We conducted two-sample uni- and multivariable mendelian randomization (MR) analysis to test whether (i) 10 cardiometabolic traits (fasting insulin, high-density lipoprotein and triglycerides representing an insulin resistance phenotype, and 7 related cardiometabolic traits: low-density lipoprotein, fasting plasma glucose, glycated haemoglobin, leptin, body mass index, glucose tolerance, and type 2 diabetes) could be causally associated with schizophrenia; and (ii) inflammation could be a shared mechanism for these phenotypes. …”
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Does ankylosing spondylitis exert a bidirectional influence on hypertension? A two-sample Mendelian randomization study by Weiran Hu, Kai Zhang, Guang Yang, Haoxu Wang, Yanzheng Gao

“…Methods: A bidirectional two-sample Mendelian randomization (MR) analysis was performed by employing five Mendelian randomization analysis methods. …”
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Causal relationship between atherosclerosis and inflammatory bowel disease risk: a two-sample Mendelian randomization study by Wenjuan Guo, Na Peng, Shiyu Du

“…Abstract Objective This study was to evaluate the causal associations of atherosclerosis with the risk of inflammatory bowel disease (IBD), and its subtypes [ulcerative colitis (UC) and Crohn’s disease (CD)]: a two-sample Mendelian randomization study. Materials and methods Single nucleotide polymorphism (SNPs) associated with atherosclerosis including CPAmax, CPSmax, brachial-femoral pulse wave velocity (bfPWV), coronary atherosclerosis, cerebral atherosclerosis, peripheral atherosclerosis, coronary artery disease (CAD) and ischemic stroke (IS) were identified from previous genome-wide association studies (GWAS). …”
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