Causal association between immune cell phenotypes and colorectal cancer: a two-sample bidirectional Mendelian randomization analysis by Wei Jiang, You Zheng, Huiying Fang

Get full text

Exploring the causal association between rheumatoid arthritis and the risk of cervical cancer: a two-sample Mendelian randomization study by Minxian Xu, Huan Chen, Tao Tan, Kaihong Xie, Hui Xie, Qing Li

Get full text

The causal association between temporomandibular joint disorders and eating disorders: a bidirectional two-sample mendelian randomization study by Esam Halboub, Mohammed Nasser Alhajj

“…This study aimed to explore the potential causal association between TMD and ED utilizing the Mendelian randomization (MR) approach. Materials and methods A bidirectional two-sample MR was conducted. …”
Get full text

Causal association between circulating α-Klotho levels and venous thromboembolism: a two-sample Mendelian randomization study by Yanmin Song, Liping Cao, Hui Long

“…However, the underlying relationship between circulating α-Klotho levels and VTE is still unclear. Methods This two-sample Mendelian Randomization (MR) study aims to explore the causal associations of circulating α-Klotho levels with different types of venous thromboembolism. …”
Get full text

Causal relationship between gut microbiota and hepatocellular carcinoma: a two-sample Mendelian randomization and case–control study by Liu Yang, Wei Wei, Yuekui Wang, Wentao Kuai, Liang Xu

“…Methods The principal study method employed was Mendelian randomization (MR). The exposure group included 7738 samples from the MiBioGen Consortium Gut Microbiota Genome-Wide Association Study (GWAS), whereas the outcome group included 8,885,115 single nucleotide polymorphisms (SNPs) from the IEU OpenGWAS project database of hepatocellular carcinoma (HCC). …”
Get full text

Evaluating the Causal Association Between Type 2 Diabetes and Alzheimer’s Disease: A Two-Sample Mendelian Randomization Study by Si Han, Tom Lelieveldt, Miriam Sturkenboom, Geert Jan Biessels, Fariba Ahmadizar

“…This study aims to clarify the causal relationship between T2DM and AD through a systematic review and meta-analysis of Mendelian randomization (MR) studies and a new two-sample MR analysis. …”
Get full text

Causal Association Between Genetically Predicted Circulating Metabolites and Pressure Ulcers: A Two-Sample Mendelian Randomization Study by Hu X, Zhang Y, Wu Y, Peng M

“…Understanding the mechanisms behind PU formation, including the role of metabolites, is crucial for effective prevention.Methods: We conducted a two-sample MR analysis to explore the causal relationship between circulating metabolites and PU. …”
Get full text

The causal effects between low back pain and cerebrospinal fluid metabolites: a two-sample Mendelian randomization study by Run Peng, Xiaoxin Wang, Wei Wang, Zeqin Li, Yuze Sun, Mingliang Yang

“…Methods We performed a two-sample Mendelian randomization (MR) analysis to examine whether there is a causal relationship between CSF metabolites and LBP. …”
Get full text

Genetic causality between insomnia and specific orthopedic conditions: Insights from a two-sample Mendelian randomization study by Mingyi Yang, Jiale Xie, Yani Su, Ke Xu, Pengfei Wen, Xianjie Wan, Hui Yu, Zhi Yang, Lin Liu, Peng Xu

“…Methods: The genome-wide association study (GWAS) summary data on insomnia were obtained from a published study, while the GWAS summary data on RA, AS, OP, and GT were sourced from the FinnGen consortium. We utilized the TwoSampleMR package of the R software (version 4.1.2) to conduct a two-sample Mendelian randomization (MR) analysis. …”
Get full text

Causal relationship between osteoporosis, bone mineral density, and osteonecrosis: a bidirectional two-sample Mendelian randomization study by Chao Zhang, Hao Yu, Yulin Miao, Biaofang Wei

“…This study aims to investigate the causal relationships between OP, bone mineral density (BMD), and ON using a bidirectional two-sample Mendelian randomization (MR) approach. Methods This study utilized genome-wide association study (GWAS) data for OP from the FinnGen database, and BMD data for the lumbar spine and femoral neck from the Genetic Factors for Osteoporosis (GEFOS) consortium. …”
Get full text

Association between sphingomyelin levels and gut microbiota abundance in Alzheimer’s disease: a two-sample Mendelian randomization study by Liping Wang, Yuyan Ding, Yu Tang, Mengqi Yang, Zhihui Yang, Xiao Yang, Jiazeng Xia

“…To determine the causal relationship between sphingolipid abundance and gut microbiota abundance at the genetic level, we conducted a Mendelian randomization (MR) investigation. Methods We first used the TwoSampleMR and MRPRESSO packages for conducting two-sample MR studies. …”
Get full text

Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study by Jiaming Su, Jiyuan Hu, Hongfang Liu, Yan Guo, Yang Shi, Yicheng Zheng, Zhaoxi Dong, Jiayou Liu, Zheyu Xu, Xinhui Yu, Jie Mei, Jing Peng, Lin Wang, Qingqing Liu

“…Abstract Objective This study aimed to utilize Mendelian randomization (MR) techniques to determine causal relationships between the plasma lipidome and the occurrence and progression of chronic kidney disease (CKD). …”
Get full text

Bidirectional two-sample Mendelian randomization analysis unveils causal association between inflammatory cytokines and the risk of diabetic nephropathy by Siyuan Song, Qianhua Yan, Jiangyi Yu

“…We aimed to further evaluate the causal association between 91 inflammatory cytokines and DN using bidirectional two-sample Mendelian randomization (MR) analysis. Method Summary statistics for DN were obtained from a publicly available genome-wide association study (GWAS) analysis. …”
Get full text

A Two‐Sample Mendelian Randomization Research Examining the Causal Association Between Ischemic Stroke and Obstructive Sleep Apnea by Qing Yu, Wei Wei, Ying Yuan

“…We adopted a two‐sample Mendelian randomization analysis to examine the causal relationship between IS (n = 440,328), LAS (n = 410,484), CES (n = 413,304), SVS (n = 198,048), and OSA (n = 451,618).The inverse variance‐weighted (IVW) method was used as the primary analysis method to assess causal relationships, with sensitivity analyses conducted using the leave‐one‐out method, MR‐Egger intercept test, MR‐PRESSO global test, and heterogeneity tests. …”
Get full text

No Bidirectional Causal Relationship Between Traumatic Brain Injury and Parkinson's Disease: A Two‐Sample Mendelian Randomization Study by Huan Wang, Yibin Huang, Ziwen Zhu, Yanzi Peng, Guolian Wei, Xijin Wang, Qiang Guan, Lingjing Jin, Ya Feng, Jingxing Zhang

“…The bidirectional two‐sample MR analyses were used to investigate the causal association between TBI and PD. …”
Get full text

Associations between Sjogren syndrome and psychiatric disorders in European populations: a 2-sample bidirectional Mendelian randomization study by Lingai Pan, Guangpeng Zhou, Guocui Wei, Qian Zhao, Yanping Wang, Qianlan Chen, Qing Xiao, Yujie Song, Xiangui Liang, Zhili Zou, Xiuxia Li, Xuan Xiong

“…Then, we conducted a 2-sample bidirectional Mendelian randomization (MR) analysis to explore the potential causal associations between SS and four major psychiatric disorders. …”
Get full text

A two sample Mendelian randomized study of the association of sex hormones and behavioral and clinical risk factors with macular hole by Zetong Nie, Naxin Duan, Xiang Zhang, Boshi Liu, Siqiong Bai, Xiaorong Li, Wenbo Li, Bojie Hu

Get full text

First evidence on the causal association between green tea and gastrointestinal health: a two sample mendelian randomization study by Zhixiong Jiang, Renlan Li, Yi Li

Get full text

SPAG11B, a potential biomarker for rheumatoid arthritis: a two-sample bidirectional Mendelian randomization analysis by Kun Lin, Qi Lin, Weifeng Lv, Yao Li, Rong Su

Get full text

The causal relationship between steroid hormones and risk of stroke: evidence from a two-sample Mendelian randomization study by Yang Zhang, Miaowen Jiang, Di Wu, Ming Li, Xunming Ji

Get full text