Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils by Yixiang Jiang, Ning Wang, Jingyi Liu, Haoran Ren, Wenkang Jiang, Yanting Lei, Xidan Fu, Miao Hao, Xiujuan Lang, Yumei Liu, Xijun Liu, Rui Li, Hulun Li

“…While the cytokines secreted by stem cells show promise in modulating post-stroke inflammation, the direct application of these supernatants in ischemic stroke treatment and the underlying mechanisms are still unclear. Methods Secretory supernatants (hMSC-L) and cell lysate products (hMSC-M) from primary human umbilical cord mesenchymal stem cells-cultured medium were administered intranasally to mice with cerebral ischemia. …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…Conclusions Our study elucidated the mechanism underlying 5-Fu-induced NAT10 downregulation, revealing that NAT10 inhibition destabilizes ERRFI1 mRNA through ac4C modifications, subsequently resulting in EGFR reactivation. …”
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Physiological impact of Trichoderma viride agents on the quality and production of melon that is grown on soils continuously cropped to melon by Jingyi Liu, Hua Lian, Jingwei Dou, Jingjing Li, Guangliang Zhu, Jiatong Wang, Guangshu Ma, Mei Li

“…At the seedling and fruiting stages, a pot experiment and a bedding experiment were conducted to study the physiological properties and yield of melon under varying concentration of Trichoderma viride kf57 agents. …”
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Association of baseline and trajectory of triglyceride-glucose index with the incidence of cardiovascular autonomic neuropathy in type 2 diabetes mellitus by Qiong Huang, Wenbin Nan, Baimei He, Zhenhua Xing, Zhenyu Peng

“…Methods Based on the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial, multivariate logistic regression models and restricted cubic splines (RCS) were deployed for elucidating the relation between baseline TyG index and the incidence of CAN. The area under the curve (AUC) of receiver operating characteristic (ROC) curve was used to assess the diagnostic value of the TyG index in predicting the risk of CAN. …”
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Conflict-associated wounds and burns infected with GLASS pathogens in the Eastern Mediterranean Region: A systematic review by Amelia Wild, Clare Shortall, Omar Dewachi, Carine Naim, Alex Green, Sarah Hussain, Aula Abbara

“…Improving primary data will facilitate the production of large, high-quality studies throughout the EMRO, including under-represented countries. Conclusion Laboratory diagnostic capacity building and improved surveillance in conflict-affected settings in the Eastern Mediterranean Region are required to assess the burden of GLASS priority pathogens in vulnerable non-combatant populations.…”
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GelMA@LNP/AST Promotes eNOS-Dependent Angiogenesis Through Autophagy Activation for the Treatment of Hind Limb Ischemia by Lai L, Wu H, Peng L, Zhang Z, Wu X, Zheng S, Su Z, Chu H

“…This effect was mainly attributed to the enhanced migration and angiogenic capabilities of endothelial cells mediated by AST. A potential underlying mechanism could be that the autophagy induced by AST increases eNOS activity.Conclusion: GelMA@LNP/AST enables complete revascularization in female mice after hind limb ischemia, thereby achieving limb preservation and restoring motor function. …”
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Framework for smartphone-based grape detection and vineyard management using UAV-trained AI by Sergio Vélez, Mar Ariza-Sentís, Mario Triviño, Antonio Carlos Cob-Parro, Miquel Mila, João Valente

“…The proposed approach achieved a precision of 0.92 and recall of 0.735, with an F1 score of 0.82 and an Average Precision (AP) of 0.802 under different operation conditions, indicating high accuracy and reliability in detecting grape bunches. …”
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Microbial community succession characteristics in an anaerobic baffled reactor during phenol gradient acclimation by Yuan LI, Chunmei YU, Daqiang CANG

“…However, the ΔG' values for these reactions were consistently greater than −20 kJ·mol−1, indicating that propionate degradation did not occur under the experimental conditions. From a thermodynamic point of view, high hydrogen partial pressure levels in the reactor affected the propionate degradation process and also inhibited sludge bioactivity. …”
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A Multidisciplinary-Based and Bundle Intervention for Controlling Carbapenem-Resistant Organisms in Neurosurgery by Zhu W, Liang Y, Xu J, Weng C

“…This study aims to observe the effect of multidisciplinary-based and bundle interventions under PDCA (plan-do-check-act) cycle management on the control of CROs in neurosurgery.Patients and Methods: We conducted a before-after study from January 2021 to December 2023, which was divided into pre-intervention phase and intervention phase. …”
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Construction and validation of a prognostic model for NK/T-cell lymphoma based on random survival forest algorithm by HUANG Zhen, HUANG Zhen, WU Yazhou

“…In the validation cohort, the area under the ROC curve (AUC) for the nomogram model at 1, 3, and 5 years was 0.745, 0.771, and 0.748, respectively, while the AUC for the RSF model was 0.764, 0.792, and 0.761 at the same time points. …”
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Network Pharmacology and Experimental Validation of the Therapeutic Effect of Baji Capsule on LPS-Induced Osteoporosis by Li Q, Li D, Tian C, Liu X, Wang H, Liu H

“…Therefore, the aim of this study was to evaluate whether Baji capsule has a therapeutic effect on lipopolysaccharide (LPS)-induced inflammatory osteoporosis and to explore the underlying mechanisms through network pharmacology.Patients and Methods: Osteoporosis model in ICR mice induced with LPS. …”
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Prevalence, influencing factors, and prediction model construction of anemia in ankylosing spondylitis based on real-world data: An exploratory study. by Yifan Gong, Kun Yang, Zhaoyang Geng, Hongxiao Liu

“…The ROC curve analysis showed that the area under the curve of the model for predicting anemia in AS was 0.857 (95% CI: 0.808 ~ 0.906). …”
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Preoperative prediction of IDH genotypes and prognosis in adult-type diffuse gliomas: intratumor heterogeneity habitat analysis using dynamic contrast-enhanced MRI and diffusion-we... by Xingrui Wang, Zhenhui Xie, Xiaoqing Wang, Yang Song, Shiteng Suo, Yan Ren, Wentao Hu, Yi Zhu, Mengqiu Cao, Yan Zhou

“…Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to evaluate IDH predictive performance. …”
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E-HEART score: A novel scoring system for undifferentiated chest pain in the emergency department by V. Yuvaraj, Sachin Sujir Nayak, S. Vimal Krishnan

“…In 48 patients with high E-HEART scores (values 7–11), MACE occurred in 97.9%. The area under receiver operating characteristics (AUROC) of E-HEART score is 0.992 (95% confidence interval: 0.98–0.99), which is significantly higher than AUROC values for HEART (0.978), TIMI (0.889), T-MACS (0.959), and HEAR (0.861), respectively (P < 0.0001). …”
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Chaihu Shugan San and Zuogui Yin synergistically improve premature ovarian failure in a rat model via the PI3K/Akt/mTOR pathway by Fei Zhang, RuiFang Liu, ZhenLing Xu, WenJie Chen, XiYa Lu, Yang Wang

“…This study aims to evaluate the therapeutic effects of Chaihu Shugan San, Zuogui Yin, and their combination on POI in a rat model and to elucidate the underlying mechanisms involving the PI3K/Akt/mTOR signaling pathway. …”
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Implementasi Algoritma Fuzzi Mamdani pada Sistem Pakar Menggunakan Software Aplikasi Matlab R2007B, Studi Kasus: Tanaman Hidroponik Selada Air by Okta Purnawirawan, Tri Afirianto

“…The results of the analysis of the FIS keluaran surface diagram show that watercress hydroponic plants can grow and develop under the following conditions: (1) nutrient levels of 1000 to 1800 PPM; (2) acidity level 3 to 6 H+/liter; and (3) temperature water level of 24o to 29o C. …”
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A Rare Case of Spontaneous Heterotopic Pregnancy at 12&nbsp;weeks of Gestation Following Natural Conception With Literature Review by Wang F, Xu Y, Dong X, Jiang P, Yu QQ

“…An urgent laparoscopic salpingectomy was performed under general anesthesia, revealing a distended right fallopian tube (3.5 cm) with a thickened appearance, bluish-purple discoloration, and a 2 mm rupture with active bleeding surrounded by clots. …”
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Dexmedetomidine versus Dexamethasone as Perineural Adjuvants in Supraclavicular Brachial Plexus Block: An Interventional Study by Charmi Hitenbhai Shah, Jinesh Pareshbhai Kothari, Nilesh Vrajmohan Shah, Rajsi Rajan Shah, Sara Mary Thomas

“…Materials and Methods: This interventional study was conducted in the Department of Anaesthesiology at Dhiraj Hospital, Vadodara, Gujarat, India from October 2023 to April 2024 on 80 patients with American Society of Anaesthesiologists (ASA) physical status I and II, aged 18 to 65 years, scheduled for surgery under supraclavicular brachial plexus block. Patients were allocated into two groups of 40 patients each. …”
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Chronic Myeloid Leukemia: Part I—Real-World Treatment Patterns, Healthcare Resource Utilization, and Associated Costs in Later Lines of Therapy in the United States by Ehab L. Atallah, Rodrigo Maegawa, Dominick Latremouille-Viau, Carmine Rossi, Annie Guérin, Eric Q. Wu, Pallavi Patwardhan

“…Costs increased from 3L to 4L; in commercially insured patients, inpatient costs were responsible for most of the cost increase between 3L and 4L, underlying these patients’ continued need for care. …”
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Research on comprehensive characterization of deep coal full aperture structure and burial depth effect by Qi Li, Xiaoxia Zhang, Zhengzong Wang, Lei Qiao, Shitan Shao

“…The fractal dimension in the high-pressure zone of the FHH model (DHP) ranged from 2.8 to 2.9, and that in the low-pressure zone (DLP) ranged from 2.1 to 2.4, indicating that coal pore structure under low-pressure conditions is relatively simple. …”
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