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5021
Temporal changes in plasma and milk lipids in response to an esophageal bolus of rumen-protected fish oil in lactating Holstein dairy cows
Published 2025-02-01“…Separated milk fat was analyzed for individual milk FA using gas–liquid chromatography and a flame-ionization detector. Data were analyzed under a mixed model with the random effect of cow, and the fixed effects of treatment, hour, and period. …”
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5022
Comparison of Healthcare Encounters and Drug Persistence in Patients With Pulmonary Arterial Hypertension Receiving Oral Selexipag, Inhaled Iloprost, or Parenteral Treprostinil: A...
Published 2022-06-01“…Further research is required to identify factors underlying these differences.…”
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5023
Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study
Published 2025-02-01“…Abstract Background Data suggest excess mortality is associated with loiasis, which is endemic to Central Africa, although the underlying mechanisms remain unknown. We hypothesized that there could be an association between Loa loa microfilarial densities (MFD) and lower spleen volume (SV) due to micro-obstruction linked to circulating microfilariae (mf). …”
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5024
Providing an Anti-Marketing Model to Prevent Criminal Behaviors in Online and Digital Businesses
Published 2024-06-01“…To ensure the collection of precise and relevant data, an effort was made to employ indicators for sample selection so the experts could have closer connections and sufficient experience related to the subject under investigation. The data collection was also carried out by employing targeted sampling and semi-structured interviews. …”
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5025
Smart Pharmaceutical Monitoring System With Personalized Medication Schedules and Self-Management Programs for Patients With Diabetes: Development and Evaluation Study
Published 2025-02-01“… BackgroundWith the climbing incidence of type 2 diabetes, the health care system is under pressure to manage patients with this condition properly. …”
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5026
Long term cost-effectiveness analysis of IDegLira in the treatment of type 2 diabetes patients compared to GLP-1RA added to basal insulin after IDegLira entered the national reimbu...
Published 2025-01-01“…In the base-case analysis, IDegLira compared to the combined regimen shows an incremental cost of -34,254 CNY and an incremental QALYs of 0.436. Under the threshold of 1 times the per capita GDP of China in 2022 (85,698 CNY), IDegLira is a dominant scheme with lower cost and better health outcome. …”
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5027
Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing
Published 2025-02-01“…Abstract Background Vestibular schwannoma (VS) is an intracranial tumor arising from the Schwann cells of the vestibular nerve and is an important cause of sensorineural hearing loss (SNHL) in humans. The mechanisms underlying this SNHL are incompletely understood and currently, there are no drugs FDA approved specifically for VS. …”
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5028
Efficacy of non-invasive brain stimulation interventions on cognitive impairment: an umbrella review of meta-analyses of randomized controlled trials
Published 2025-02-01“…Abstract Background The impact of noninvasive brain stimulation (NIBS) on cognitive and mental outcomes in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) remains under debate due to contradictory findings from systematic reviews and meta-analyses (SRMAs). …”
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5029
The Opportunity of Using Diode Laser with the Length of 1940 nm in the Treatment of Hemorrhoids
Published 2022-08-01“…Surgical intervention was performed under both local and spinal anesthesia. Intraoperative complications in the form of hemorrhoidal node bleeding were noted in 3 patients. …”
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5030
Examining Sex Differences in Visual Reliance During Postural Control in Intercollegiate Athletes
Published 2021-10-01“… # Study Design Cross-sectional Study # Methods Static postural stability was assessed during a single session for football, soccer, basketball, and volleyball intercollegiate athletes (males, n=135, females, n=51) under eyes open (EO) and eyes closed (EC) conditions via performance of single limb stance on a force plate. …”
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5031
Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer
Published 2025-02-01“…DiscussionThese findings highlight circPCDH11Y as a promising candidate for early detection of t-NEPC and provide new insights into the molecular mechanisms underlying prostate cancer progression. Further validation in clinical samples is required to establish its diagnostic and therapeutic potential, which could significantly improve the management of treatment-resistant prostate cancer. …”
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5032
Trends in the utilisation of maternal and child healthcare services from the public and private health sectors in India, 2005–2021: an analysis of cross-sectional survey data
Published 2025-02-01“…Market sustainability of key MCH indicators was assessed by level of MCH services and subsidisation.Participants 36 850, 190 898 and 176 843 ever-married women aged 15–49 years, 4440, 22 500 and 15 334 children under 5 years of age with diarrhoea before the survey, and 2552, 6960 and 6117 children with symptoms of acute respiratory infections (ARI) in NFHS 2005–2006, 2015–2016 and 2019–2021, respectively.Outcome measures The study used three maternal healthcare indicators: women had four or more antenatal care (ANC) visits, had institutional delivery, and received postnatal care (PNC); and two child healthcare indicators: care seeking for ARI and diarrhoea.Results In India, utilisation of maternal healthcare services increased over the last 15 years: four or more ANC visits increased from 37% to 58% and PNC of mothers increased from 33% to 78% between 2005–2006 and 2019–2021. …”
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5033
Epidemiological and Clinical Aspects of Ulcerative Colitis in Mosul city, Iraq
Published 2019-08-01“…Out of 102 female patients, 45 (44.1%) were more frequently under uses of contraceptive pills. 60 (58.8%) of patients was in severe cases of UC and followed by moderate 35 (34.3%). …”
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5034
Effect of HBeAg/anti-HBe coexistence on HBeAg seroconversion in treatment-naïve chronic hepatitis B patients with peginterferon-α
Published 2025-02-01“…The nomogram model constructed based on these four independent correlates demonstrated good discrimination (area under the curve = 0.866), calibration, and clinical adaptability. …”
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5035
Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD
Published 2025-02-01“…Cholesterol accumulation is known to drive cellular senescence; however, its underlying mechanisms are not fully understood. ATP-binding cassette transporter A1 (ABCA1) plays an important role in cholesterol homeostasis, and its expression and trafficking are altered in APOE4 and AD models. …”
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5036
The association between maternal tobacco smoking during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring: A systematic review and meta-analysi...
Published 2025-01-01“…Future research should explore underlying mechanisms and potential confounders further.…”
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5037
HOLSEA-NL: a Holocene water level and sea level indicator dataset for the Netherlands
Published 2025-02-01“…<p>Deltas and coastal plains worldwide developed under the influence of relative sea level rise (RSLR) during the Holocene. …”
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5038
Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study
Published 2025-02-01“…Further research is needed to explore the underlying causes of HCA to inform targeted preventive measures.…”
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5039
A note on the global existence and boundedness of an N-dimensional parabolic-elliptic predator-prey system with indirect pursuit-evasion interaction
Published 2025-02-01“…We investigate the two-species chemotaxis predator-prey system given by the following system: ut=Δu−χ∇⋅(u∇w)+u(λ1−μ1ur1−1+av),x∈Ω,t>0,vt=Δv+ξ∇⋅(v∇z)+v(λ2−μ2vr2−1−bu),x∈Ω,t>0,0=Δw−w+v,x∈Ω,t>0,0=Δz−z+u,x∈Ω,t>0,\left\{\begin{array}{ll}{u}_{t}=\Delta u-\chi \nabla \cdot \left(u\nabla w)+u\left({\lambda }_{1}-{\mu }_{1}{u}^{{r}_{1}-1}+av),& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ {v}_{t}=\Delta v+\xi \nabla \cdot \left(v\nabla z)+v\left({\lambda }_{2}-{\mu }_{2}{v}^{{r}_{2}-1}-bu),& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ 0=\Delta w-w+v,& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ 0=\Delta z-z+u,& x\in \Omega ,\hspace{0.33em}t\gt 0,\end{array}\right. in a bounded domain Ω⊂RN(N≥1)\Omega \subset {{\mathbb{R}}}^{N}\left(N\ge 1) with smooth boundary, where parameters χ,ξ,λi,μi>0\chi ,\xi ,{\lambda }_{i},{\mu }_{i}\gt 0, and ri>1(i=1,2){r}_{i}\gt 1\hspace{0.33em}\left(i=1,2). Under appropriate conditions, utilizing suitable a priori estimates, we demonstrate that if (N−2)+N<max(r1−1)(r2−1),4N2,(r1−1)2N,(r2−1)2N\frac{{\left(N-2)}_{+}}{N}\lt \max \left\{\phantom{\rule[-0.95em]{}{0ex}},\left({r}_{1}-1)\left({r}_{2}-1),\frac{4}{{N}^{2}},\left({r}_{1}-1)\frac{2}{N},\left({r}_{2}-1)\frac{2}{N}\right\}, then the system admits a unique, uniformly bounded global classical solution. …”
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5040
MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism
Published 2025-02-01“…The optimal drug concentration for inducing CPO was subsequently determined, and in vitro experiments revealed that HUVEC activity was significantly decreased in the CPO group under hypoxic culture, accompanied by increased DLAT oligomerization, decreased SDHB expression, increased HSP70 expression. …”
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