Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…Up-regulation of anti-apoptotic genes increases mitochondrial membrane potential, underlying multidrug resistance. Increased expression of BCL2, BCL2L1 (BCL-XL), and BCL2A1 (BFL1) drives resistance to venetoclax, but expression can be overcome by the potent non-covalent BTK inhibitor pirtobrutinib. …”
Get full text

A multitasking ant system for multi-depot pick-up and delivery location routing problem with time window by Haoyuan Lv, Ruochen Liu, Jianxia Li

“…They are powerless to simultaneously explore the solution spaces of multiple routing tasks under different location schemes. Furthermore, ignoring the potential general knowledge among different schemes leads to redundant optimization. …”
Get full text

Kinetic, Equilibrium and thermodynamic studies on the biosorption of Cd(II) from aqueous solutions by the leaf biomass of <i>Calotropis procera</i> – ‘Sodom apple’ by Babalola J Oyebamiji, LC Overah, Adesola Babarinde, Vincent O Oninla, A Olatunde

“…The calculated thermodynamic parameters (ΔG° -4.846 kJmol-1, ΔH° 10.60 kJmol-1 and ΔS° 0.052 kJK-1mol1) showed that the biosorption of Cd (II) is feasible, spontaneous, endothermic and highly disordered in nature under the experimental conditions. These findings indicate that the leaf of Calotropis procera could be employed in the removal of Cd (II) from industrial effluents. …”
Get full text

Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease by Shangpei Wang, Yajie Cai, Yibin Zhao, Yongqiang Yu, Xianwen Chen, Longsheng Wang

“…Background: The resting-state cerebral blood flow (CBF) alterations in Parkinson’s disease (PD) patients and tremor-dominant (TD) subtype have been explored. However, the underlying molecular architecture correlated with the altered CBF remains unknown. …”
Get full text

Risk Factors and Prevention of Upper Gastrointestinal Complications Associated with Nonsteroidal Anti-Inflammatory Drugs by N. V. Bakulina, S. V. Tikhonov, K. A. Nagornova

“…Esomeprazole has a number of pharmacokinetic advantages — a large area under the pharmacokinetic curve, the ability to inhibit CYP4502C19, which determines the high efficiency of therapy in fast and ultrafast metabolizers. …”
Get full text

Frailty risk prediction models for patients undergoing maintenance hemodialysis in China: a systematic review by Yu Zhong, Songmei Cao, Liangying Chen, Teng Li, Wei Ye

“…A total of 12 predictive models were included across these 10 studies; three of these were solely model development studies, while seven were both model development and validation. The area under the curve (AUC) for the subjects’ operating characteristics was > 0.7 in all ten studies. …”
Get full text

Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simul... by Xiao-Chen Wei, Ming-Feng Zhao, Hai-Rong Lv, Xia Xiao

“…Methods: Monte Carlo simulations were performed using previously published pharmacokinetic parameters and pharmacodynamic data to evaluate the efficacy of the simulated dosage strategies in terms of area under the concentration-time curve/minimum inhibitory concentration targets of tedizolid. …”
Get full text

Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…This review elucidates the pharmacological mechanisms underlying the protective effects of wogonin in CNS diseases, including ischemic stroke, hemorrhagic stroke, traumatic brain injury, epilepsy, anxiety, neurodegenerative diseases, and CNS infections. …”
Get full text

TEACHING AND ASSESSING INDEPENDENT LISTENING IN AN ONLINE COURSE FOR TRANSLATION MAJORS by Olga G. Kvasova, Nataliia K. Liamzina, Roksoliana I. Radchuk, Yulia I. Trykashna

“…Logs/journals/portfolios belong to alternative assessments, which are still innovative and under-researched in language pedagogy, although reflecting the much-welcomed shift from assessment of learning towards assessment for learning.  …”
Get full text

Machine Learning Applications to Dust Storms: A Meta-Analysis by Reem K. Alshammari, Omer Alrwais, Mehmet Sabih Aksoy

“…It aims to compare the applied models and the types of data used in the literature under study. Given that the location of a dust storm event is essential, the properties of dust storms are discussed in relation to the region. …”
Get full text

Estimated inpatient malnutrition prevalence, screening tool utilization, and dietitian referral rates across hospitals during extension of phase 2 of More-2-Eat by Yingying Xu, Rachel A. Warren, Shirley M. Peters, Sonya Boudreau, Tina N. Strickland, Mari Somerville, Brenda L. MacDonald, Heather Keller, Leah E. Cahill

“…Conclusion: Inpatient malnutrition is prevalent in NS hospitals but under-diagnosed due to gaps in screening. INPAC implementation increased dietitian referrals, SGA, and malnutrition diagnosis. …”
Get full text

The epididymal microenvironment in Akodon cursor (Muridae, Sigmodontinae, Akodontini): The lifetime of spermatozoa from production to maturation by Tatiana Prata Menezes, Fernanda Carolina Ribeiro Dias, Nara Clara Lazaroni e Merchid, Camila Folly Batista, Camilo Jose Ramirez-Lopez, Arabela Guedes de Azevedo Viana, Renner Philipe Rodrigues Carvalho, Adrielli Ribeiro Araújo, José Lino-Neto, Gisele Lessa, Arlindo A. Moura, Mariana Machado-Neves

“…These findings provide valuable insights into the molecular mechanisms underlying sperm maturation in this species. In conclusion, the epididymis of A. cursor shares similarities with other rodent species but exhibits unique characteristics, such as shorter sperm transit time.…”
Get full text

Quantifying the sources and health risks of groundwater nitrate via dual NO isotopes and Monte Carlo simulations in a developed planting-breeding area by Jianwei Liu, Shuo Qiao, Shilong Zhao, Hui Chen, Yong Wu, Donghao Li, Ping Liu, Ling Li

“…However, the contribution of N fertilizer may be underestimated because it has undergone a long-term applied history and have progressively accumulated in the soil, and then promoted the entry of groundwater under frequent rainfall and irrigation practices. …”
Get full text

Iron(III) edta-accelerated growth of gold/silver core/shell nanoparticles for wide-range colorimetric detection of hydrogen peroxide by Mahdi Hemmati, Amir Hossein Q. Selakjan, Forough Ghasemi

“…This characteristic was exploited to measure different concentrations of H2O2. Under well-optimized conditions, various concentrations of H2O2 ranging from 1.0 to 50 µΜ have shown an acceptable linear relationship with different colors and, with a limit of detection (LOD) of 230 nM. …”
Get full text

Implementation of patient-centred care: which organisational determinants matter from decision maker’s perspective? Results from a qualitative interview study across various health... by Lena Ansmann, Holger Pfaff, Kira Isabel Hower, Vera Vennedey, Hendrik Ansgar Hillen, Ludwig Kuntz, Stephanie Stock

“…Objectives Health and social care systems, organisations and providers are under pressure to organise care around patients’ needs with constrained resources. …”
Get full text

Infertility and Social Issue Have the Most Significant Impact on Health-Related Quality of Life Among Polycystic Ovarian Syndrome Women in South India by L. Hariprasath, D. Selvakumar, V. Dharani, K. K. Durgalakshmi, V. G. Abilash, T. S. Gopenath, S. Nishu

“…Settings and Design: A total of 126 females in the first phase and 356 females in the second phase between the age group of 18–40 years characterised under the Rotterdam criteria were selected for the study. …”
Get full text

Effect of laser and light emitting diode bleaching techniques on micro-leakage of dental composite postoperatively using two different bonding systems by Shalaw S. Jawhar, Bassam K. Amin

“…When the scores of micro-leakage of the six subgroups were compared, the differences among the groups were found to be statistically significant (p < 0.001). there was no significant difference found between the adhesive systems after treatment with the same bleaching techniques. Conclusion: Under the conditions of this study, micro-leakage of composite resin restorations differs according to the bleaching techniques used with no significant difference was found between the adhesive systems, and restorations post bleaching procedure was necessitate replacing by the clinician due adverse effects on tooth restoration interface. …”
Get full text

CHURCH RESPONSE TO SECURITY CHALLENGES IN THE 21ST CENTURY: THE NIGERIAN EXPERIENCE by Oyebode Paul Jegede, Abare Yunuwa Kallah

“…The study discovered that no nation can develop where lives and properties are constantly under threat. The paper also recommended that church leaders should use their pulpits to promote awareness among members of the Church on the need for security of their lives and loved ones and the society at large. …”
Get full text

Evaluation of conditioning temperature and retention time on Enterococcus faecium inactivation, vitamin stability, metabolizable energy, and amino acid digestibility by J.I. Vargas, W.J. Pacheco, L.M. Almeida, C.W. Starkey, E. Monu

“…In contrast, water-soluble vitamins were stable under varying conditioning temperatures and retention times. …”
Get full text

Effects of water nutrient concentrations on stream macroinvertebrate community stoichiometry: a large-scale study by Beck, Miriam, Billoir, Elise, Usseglio-Polatera, Philippe, Meyer, Albin, Gautreau, Edwige, Danger, Michael

“…An increased nutrient content (e.g. phosphorus) in primary and detrital resources under nutrient enriched conditions should favour taxa with a high demand for this nutrient. …”
Get full text