Characterization and quantification of proteins secreted by single human embryos prior to implantation by Maurizio Poli, Alessandro Ori, Tim Child, Souraya Jaroudi, Katharina Spath, Martin Beck, Dagan Wells

“…Our work paves the way for the development of “next‐generation” embryo competence assessment strategies, based on functional proteomics.…”
Get full text

Inorganic-bacterial biohybrids for efficient solar-driven nitrogen fixation by Xue Zhou, Dan Wu, Yingjie Zhang, Tianhang Feng, Wenming Zhang, Zhonghai Zhang

“…This study underscores the potential of inorganic-bacterial biohybrid systems in solar-chemical conversion, paving the way for more diverse and functional approaches to harnessing solar energy for sustainable chemical production.…”
Get full text

Combining 3‐D Probabilistic Kinematic Modeling With Thermal Resetting Measurements: An Approach to Reduce Uncertainty in Exhumation Histories by Sofia Brisson, Denise Degen, David Nathan, Florian Wellmann, Christoph vonHagke

“…The resulting, more robust model can then be used to re‐interpret the thermal resetting data. …”
Get full text

Designing wind turbines for profitability in the day-ahead market by M. K. Mehta, M. Zaaijer, D. von Terzi

“…The goal of this study is to optimize the design for a new set of objective functions and analyze how various day-ahead market conditions and objectives drive turbine design. …”
Get full text

Balancing public safety and civil rights: Successes and challenges of AI-based video surveillance systems by S.S. Vaddiparti, F. Babaiev

“…The research examined the functional capabilities of intelligent video systems based on machine learning and deep learning. …”
Get full text

FAViTNet: An Effective Deep Learning Framework for Non-Invasive Fetal Arrhythmia Diagnosis by Bipin Samuel, Malaya Kumar Hota

“…In this work, authors aim to develop a three-stage fetal arrhythmia detection framework comprised of 1) fECG extraction from abdominal Electrocardiogram (aECG) signal based on functional link neural network adaptive filter, 2) denoising of extracted fECG exploiting a generative adversarial network where the generator and the discriminator follow robust architectures, and 3) fetal arrhythmia detection based on FAViTNet architecture. …”
Get full text

Integrated ATAC‐seq and RNA‐seq analysis identifies key regulatory elements in NK cells activated with feeder cells and IL‐2 by Pedram Motallebnejad, Zion Lee, Jennifer L. One, Frank Cichocki, Wei‐Shou Hu, Samira M. Azarin

“…The transcriptomic and epigenetic characterization of NK cells presented in this study could facilitate the ex vivo expansion and engineering of functionally superior NK cells.…”
Get full text

Assessing the Influence of Selected Permeabilization Methods on Lymphocyte Single-Cell Multi-Omics by Shifan Ding, Na Lu, Hassan Abolhassani

“…(1) Background: Single-cell multi-omics is a powerful method for the dissection and detection of complicated immunologic functions and synapses. However, most currently available technologies merge datasets of different omics from separate portions of the same sample to generate combined multi-omics. …”
Get full text

A comparative study of deep reinforcement learning for crop production management by Joseph Balderas, Dong Chen, Yanbo Huang, Li Wang, Ren-Cang Li

“…This comparative analysis provides critical insights into the strengths and limitations of each approach, advancing the development of more effective RL-based crop management strategies.…”
Get full text

Advanced Digital System for International Collaboration on Biosample-Oriented Research: A Multicriteria Query Tool for Real-Time Biosample and Patient Cohort Searches by Alexandros Fridas, Anna Bourouliti, Loukia Touramanidou, Desislava Ivanova, Kostantinos Votis, Panagiotis Katsaounis

“…This study presents a novel platform designed to address these issues, enabling researchers to conduct high-quality research more efficiently and at reduced costs. The platform employs a modular, distributed architecture that ensures high availability, redundancy, and interoperability among diverse stakeholders, as well as integrates advanced features, including secure access management, comprehensive query functionalities, real-time availability reporting, and robust data mining capabilities. …”
Get full text

Knockout of Apolipoprotein E in rabbit promotes premature intervertebral disc degeneration: A new in vivo model for therapeutic approaches of spinal disc disorders. by Anja Beierfuß, Hermann Dietrich, Christian Kremser, Monika Hunjadi, Andreas Ritsch, Thomas Rülicke, Claudius Thomé, Demissew Shenegelegn Mern

“…Intervertebral disc (IVD) degeneration that accelerates the loss of disc structural and functional integrities is recognized as one of the major factors of chronic back pain. …”
Get full text

Comparison of dCas9-activator complexes for the activation of PDX1 and NGN3 pancreatic genes using the CRISPR system by Ersin Akıncı, Mehmet Fatih Cengiz, Fatma Akçakale Kaba, Adem Kaba

“…This study presents a novel approach to generate insulin-producing β cells from non-β cell sources using the CRISPR/dCas9 gene activation system. …”
Get full text

The legal conflictology in constitutional and municipal law by Irina A. Tretyak

“…The legal conflict arises about legal phenomena, it is realized under the influence and with the application of legal norms, it is resolved on the basis of legal regulation;– there is a special kind of political conflict that arises within the existing government, where each of the groups within the ruling class has more private interests and its own vision of the situation.Conflictology of constitutional and municipal law bases on the general theoretical postulates of the science of social conflicts. …”
Get full text

Barriers and challenges: a descriptive qualitative study of job satisfaction among direct care workers who provide long-term care services in Shandong Province, China by Qiang Sun, Jia Yin, Jing Gao

“…Background The special nature of the functional ability of older individuals with disabilities places higher demands on the quantity and quality of long-term care (LTC) services. …”
Get full text

Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy by Bin Gong, Qiuyun Zhang, Jiayi Chen, Yijie Qu, Xuanxuan Luo, Weiqi Wang, Xiaohua Zheng

“…Consequently, it is crucial to design functionalized nanoplatforms that integrate glutathione depletion with porphyrin-based metal–organic frameworks to significantly boost photodynamic therapy efficacy. …”
Get full text

A New Extention of the Odd Inverse Weibull-G Family of Distributions: Bayesian and Non-Bayesian Estimation with Engineering Applications by Yassmen Y. Abdelall, Amal Soliman Hassan, Ehab M. Almetwally

“…In this work, we propose a novel generator called the "extended odd inverse Weibull-generator" to obtain better distribution flexibility. …”
Get full text

Polishing inner wall of crossed deep micropores using magnetic microabrasive jet technology by Zezhi WANG, Jie WANG, Xiaogang MA, Fan LI, Xinya FAN, Yan CHEN

“…In view of the problems of conventional finishing processing of cross deep micro-holes being limited by size, uneven processing, and poor quality, and combined with the characteristics of a stable removal function and strong adaptability of the abrasive jet, the magnetic micro-abrasive jet technology finishing processing method is proposed to improve the quality of the inner wall of cross deep micro-holes.MethodsAn independent magnetic abrasive jet device was used to carry out finishing tests on the cross deep micro-holes, and an electromagnetic device was used to generate a focusing magnetic force near the nozzle outlet. …”
Get full text

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer by Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu

“…PUM2 was carried m6A and recognized by IGF2BP2, and CPSF6 was recruited at the proximal polyadenylation signal (pPAS) to generate the short‐3′UTR transcript. The short PUM2 transcript was more stable than the long transcript, which promoted the malignant progression of OC. …”
Get full text

Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…We created tumor maps and derived plots showing the fraction of CD4 and CD8 T cells against the distance to the nearest vessel and oxygen pressure. To assess their function and transcriptional changes caused by hypoxia, effector T cells were generated and cultured under hypoxia (0.5% oxygen) or normoxia (21% oxygen). …”
Get full text

Transparent reporting items for simulation studies evaluating statistical methods: Foundations for reproducibility and reliability by Coralie Williams, Yefeng Yang, Malgorzata Lagisz, Kyle Morrison, Lorenzo Ricolfi, David I. Warton, Shinichi Nakagawa

“…Abstract Simulation studies are essential tools to assess statistical methods. Functioning as controlled experiments, simulations generate data from known underlying processes. …”
Get full text