COTE and Pulmonary Comorbidities Predict Moderate-to-Severe Acute Exacerbation and Hospitalization in COPD by Chen Q, Wang X, Yao X, Zhang L, Liu X

“…Qinglin Chen,1,* Xinmao Wang,1,* Xiujuan Yao,1 Luo Zhang,2– 4 Xiaofang Liu1 1Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission, Beijing, People’s Republic of China; 3Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education of China, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofang Liu, Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, No.2, Xinanhuan Road, Yizhuang District, Beijing, 100176, China, Email xfliutrhos@163.com Luo Zhang, Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University; Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education of China, Beijing Institute of Otolaryngology, No. 17, Hougou Hutong, Chongnei, Dongcheng District, Beijing, 100730, China, Email dr.luozhang@139.comPurpose: The aim of this study was to explore the predictive value of the chronic obstructive pulmonary disease (COPD) specific comorbidity test index (COTE) and pulmonary comorbidities for moderate-to-severe acute exacerbation and hospitalization in COPD patients.Patients and Methods: This was a retrospective cohort study. …”
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Impact of COVID-19 lockdown-associated visitor restrictions on mother-child interaction and emotional state of women in the puerperium – a retrospective cohort study by Irina Höhn, Anett Hernadi, Reto Zihlmann, Christina Coelius, Katharina Walter, Amr Hamza, Nicole Ochsenbein-Kölble, Leonhard Schäffer

“…We hypothesise that this is unlikely caused solely by isolation, as both groups were equally affected independently of the possibility of partner support. …”
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Survival Benefit of Adjuvant Treatment with Huaier Granules Plus Lenvatinib in Hepatocellular Carcinoma Patients with Tumors Greater Than 5 cm After Radical Hepatectomy by Liu C, Bai Y, Bai Q, Parra MA, Zhao L, Zou J, Cao Q, Liu H, Yang H

“…This study investigated potential adjuvant treatment strategies for HCC patients who exhibit multiple recurrence factors after radical resection.Methods: A retrospective analysis was conducted on data from 243 patients who underwent radical resection for HCC and exhibited high recurrence factors at the First Affiliated Hospital of Harbin Medical University. …”
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Spatial Epidemiologic Analysis of Fetal Birth Defects in Guangxi, China by Peng Z, Huang X, Wei J, Chen B, Liang L, Feng B, Wei Q, He S

“…Zhenren Peng,1– 5,* Xiuning Huang,4,5,* Jie Wei,4,5,* Biyan Chen,4,5 Lifang Liang,4,5 Baoying Feng,4,5 Qiufen Wei,1– 5 Sheng He1– 5 1Birth Defects Research Laboratory, Guangxi Clinical Research Center for Birth Defects, Nanning, 530002, People’s Republic of China; 2Birth Defects Research Laboratory, Guangxi Key Laboratory of Reproductive Health and Birth Defect Prevention, Nanning, 530002, People’s Republic of China; 3Birth Defects Research Laboratory, Guangxi Clinical Research Center for Pediatric Diseases, Nanning, 530002, People’s Republic of China; 4Birth Defects Research Laboratory, Birth Defects Prevention and Control Institute of Guangxi Zhuang Autonomous Region, Nanning, 530002, People’s Republic of China; 5Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiufen Wei, Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, No. 59 Xiangzhu Avenue, Nanning, Guangxi Zhuang Autonomous Region, 530002, People’s Republic of China, Email Wqf2024@163.com Sheng He, Birth Defects Research Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, No. 59 Xiangzhu Avenue, Nanning, Guangxi Zhuang Autonomous Region, 530002, People’s Republic of China, Email heshengbiol@163.comPurpose: To apply various spatial epidemiological approaches to detect spatial trends and geographical clusters of birth defects (BDs) prevalence in Guangxi, China, and to explore the risk factors for BDs.Methods: Between 2016 and 2022, the Guangxi Birth Defects Monitoring Network (GXBDMN) monitored a total of 4.57 million fetuses in this study. …”
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RGD-Functionalized Ginsenoside Rg3 Liposomes for Alleviating Oxidative Stress and Choroidal Neovascularization in Age-Related Macular Degeneration by Zhou J, Zhao D, Niu S, Meng W, Chen Z, Li H, Liu Y, Zou L, Li W

“…This study aimed to develop a multitargeted therapeutic strategy for AMD by leveraging the antioxidant and anti-angiogenic properties of ginsenoside Rg3 (Rg3).Methods: RGD-Rg3@Lips was formulated to encapsulate Rg3 and modified with (Arginine-Glycine-Aspartic Acid, RGD) peptides for targeted delivery. …”
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Insulin-Like Growth Factor Binding Protein, Acid-Labile Subunit Serum Level During the Acute and Convalescent Stage of SARS-CoV-2 Infection Depicted in a Longitudinal Study of 72 P... by Gad H, Mahmoud MA, Antar M, Sayed Ahmed A, Laudanski K

“…Here, we investigate if serum IGFALS during the acute response to SARS-CoV-2 will not be likely to accompany immune response during acute phase and convalescence.Patients and Methods: We recruited patients hospitalized with PCR-confirmed SARS-CoV-2 infection in 2020 and have blood collected after securing consent (tadm), at 48 hours (t48hrs), 7 days (t7d), and after discharge from hospital (tlong). …”
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The contribution of personalized video feedback to robotic partial nephrectomy training in realistic 3D tumor kidney models: design, production and implementation by Ahmet Furkan Sarıkaya, Kayhan Tarım, Ersin Köseoğlu, Arif Özkan, İbrahim Can Aykanat, Baris Esen, Umut Can Karaarslan, Mustafa Müdüroğlu, Şevval Kanlı, Murat Can Kiremit, Yakup Kordan, Mevlana Derya Balbay, Tarık Esen, Serdar Aydın, Serdar Aydın, Abdullah Erdem Canda, Abdullah Erdem Canda

“…This study investigates the impact of 3D-printed renal models and video-based feedback on skill acquisition in robotic partial nephrectomy training.MethodsForty urology residents without prior robotic surgery experience participated in this study. …”
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Analysis of Cardiotoxicity and Risk Factors of Breast Cancer Chemotherapy Drugs: A Five-Year Single-Centre Retrospective Study in Early Breast Cancer by Ju F, Gu H, Yu L, Zhao G, Liu Y, Yin D, Niu J, Xue T, Yin C, Jiao L, Li C, Wu J, Ji Y

“…Feng Ju,1,* Hong Gu,1,* Lijiang Yu,2 Guangyu Zhao,1 Yin Liu,1 Dengyang Yin,1 Jiali Niu,1 Ting Xue,1 Chunxia Yin,1 Lingyun Jiao,1 Chaoqun Li,1 Jian Wu,3 Yong Ji4 1Department of Pharmaceutical Administration, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 2Department of Oncology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 3Department of Rehabilitation, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China; 4Department of General Surgery, Jingjiang People’s Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Wu, Department of Rehabilitation, Jingjiang People’s Hospital Affiliated to Yangzhou University, No. 28, Zhongzhou Road, Jingjiang, Jiangsu, 214500, People’s Republic of China, Tel +86 0523-84995225, Email wu_wuwujianhh1201@21cn.com Yong Ji, Department of General Surgery, Jingjiang People’s Hospital Affiliated to Yangzhou University, No. 28, Zhongzhou Road, Jingjiang, Jiangsu, 214500, People’s Republic of China, Tel +86 0523-84995225, Email jiyong_jy615@163.comObjective: To investigate the cardiotoxicity of breast cancer (BC) chemotherapy drugs and analyse their risk factors.Methods: Through the electronic medical record system, the data of 415 patients with early BC (EBC) who had undergone a complete chemotherapy cycle were retrospectively collected within 5 years from the beginning of chemotherapy. …”
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Impact of Subsequent Treatment on Clinical Outcomes in Patients with EGFR-Mutant Non-Small Cell Lung Cancer Transformed to Small-Cell Lung Cancer by Chen CY, Ko HW, Hu PW, Chang CY, Chen CY, Chang SC, Chiu YC, Wei YF

“…This study aimed to investigate the clinical factors and treatments associated with outcomes in this group.Patients and Methods: This retrospective multicenter study enrolled patients with SCLC transformed from advanced NSCLC after progression on EGFR-TKI treatment. …”
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A Statistical Approach to Assess Biological Equivalent Mean Organ Dose (MOD) for Different Fractionations in Thoracic Radiotherapy by Siyao Zhong, Guangshan Wang, Xiaohang Qin, Yinghui Li, Bin Sun, Feng-Ming (Spring) Kong, Yuyan Gao, Jian-Yue Jin

“…<b>Purpose:</b> This study aims to provide an approach that can reasonably estimate the possibility of toxicity using a biological equivalent mean organ dose (MOD)-based model from the 2 Gy per fraction era for various fractionations. <b>Methods and Materials:</b> The dose volume histograms (DVHs) of 272 patients treated with radiotherapy for lung cancer at a prescribed dose of 2 Gy × 30 f were used for analysis. …”
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Adherence to Medical Treatment in Elderly Patients with Coronary Artery Disease in the Settings of Primary Outpatient Care by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebneva, N. N. Shindryaeva, D. A. Klyuev, L. N. Stepanyan, A. M. Lutsenko, A. T. Tsai, A. A. Danilova

“…To study medication adherence in elderly patients with coronary artery disease (CAD) in primary care practice.Material and methods. The study conducted in out-patient clinic of Moscow city. 293 elderly (≥65 years) patients with established CAD included. …”
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Distinct Airway Microbiome and Metabolite Profiles in Eosinophilic and Neutrophilic Asthma by Liu S, Lin Z, Zhou J, Yang X, You L, Yang Q, Li T, Hu Z, Zhan X, Jiang Y, Sun B

“…While allergen triggers are well-known, the role of the airway microbiome and metabolites in asthma exacerbations remains poorly understood.Methods: We recruited 64 participants (24 EA, 20 NEA, 20 healthy controls [HC]) for the discovery cohort, with validation in an external cohort (10 EA, 8 NEA, 8 HC). …”
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Comparing cervical cerclage, pessary and vaginal progesterone for prevention of preterm birth in women with a short cervix (SuPPoRT): A multicentre randomised controlled trial. by Natasha L Hezelgrave, Natalie Suff, Paul Seed, Vicky Robinson, Jenny Carter, Helena Watson, Alexandra Ridout, Anna L David, Susana Pereira, Fatemeh Hoveyda, Joanna Girling, Latha Vinayakarao, Rachel M Tribe, Andrew H Shennan, SuPPoRT Collaborating Team

“…<h4>Conclusions</h4>In this study, we found that for women who develop a short cervix, cerclage, pessary, and vaginal progesterone were equally efficacious at preventing PTB, as judged with a 20% equivalence margin. …”
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Rapid Initiation of Antiretroviral Therapy Suppresses T Cell Pathological Proliferation and Improves Immune Recovery in People Living with HIV by Ji J, Guo C, Li Z, Cai M, Wang R, Chen X, Zhang Y, Wu H, Zhang T, Zhang Y

“…The objective of this research is to examine how rapid ART affects T-cell pathological proliferation, immune recovery, and systemic inflammation in PWH.Patients and Methods: In this cross-sectional study (conducted at Beijing Youan Hospital, Capital Medical University, China, from April 1 to September 18, 2022), we recruited 39 PWH, including 23 in the rapid ART group (within 30 days) and 16 in the non-rapid ART group (after 180 days). …”
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Immunological Efficacy and Safety of a New Pneumococcal Polysaccharide Conjugated Thirteen-Valent Vaccine in the Immunization of Adults and Children (Results of Clinical Studies in... by I. V. Feldblium, M. H. Alyeva, A. V. Bikmieva, V. V. Romanenko, O. A. Rychkova, A. N. Galustyan

“…To evaluate the immunological efficacy and safety of the pneumococcal polysaccharide conjugate adsorbed thirteen-valent (PCV13) vaccine in the immunization of adults and children in theRussian Federation.Materials and methods. The immunological efficacy and safety of the pneumococcal polysaccharide conjugated adsorbed thirteen-valent vaccine were studied in a prospective comparative randomized double-blind study in parallel groups in adult volunteers aged 18 to 65 years and a multicenter open comparative study in parallel groups in young children. …”
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Uncovering the Mechanisms of BaBaoWuDanYaoMo Against Influenza A Virus and Virus-Induced Inflammation Based on Network Pharmacology and Pharmacological Evaluation by Lei B, Su Y, Chen R, Chen Z, Liu B, Chen Y, Zhou M, Wang X, Ma Q

“…To predict its therapeutic targets via network pharmacology and verify the therapeutic effect and the mechanism of BB against influenza virus in vitro and in vivo.Material and Methods: The potential active and underlying mechanism of BB in the treatment of influenza virus was predicted through network pharmacological strategies and Molecular Docking. …”
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Utility of 131I-HLX58-Der for the Precision Treatment: Evaluation of a Preclinical Radio-Antibody-Drug-Conjugate Approach in Mouse Models by Liu Y, Wang X, Zhang N, He S, Zhang J, Xu X, Song S

“…Leveraging the radiosensitizing ability of Deruxtecan (DXd) and the internal radiation therapy of 131I for tumors, we aimed to develop the first radio-antibody-drug conjugates (RADCs) for the treatment of gastric cancer.Methods: The CLDN18.2-specific antibody HLX58 was conjugated with the payload DXd through a cleavable maleimide glycynglycyn-phenylalanyn-glycyn (GGFG) peptide linker. …”
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Spleen Volume Dynamics and Survival Outcomes in HCC Patients Undergoing Immune Checkpoint Inhibitors: A Retrospective Analysis by Fu X, Jiang S, Li Y, Guo Y, Gong B, Lou J, Li Y, Wang S, Sun Y, Ren Y, Chen Q, Yang L

“…This study investigated the prognostic impact of spleen volume (SV) on the survival in hepatocellular carcinoma (HCC) patients receiving immune checkpoint inhibitors (ICIs).Patients and Methods: This retrospective study included 224 HCC patients treated with ICIs, categorized into Higher and Lower SV groups by median SV and further into SV increased and Non-SV increased groups based on changes in SV at 3 months after ICIs. …”
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Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget&amp;rsquo;s Disease: A Retrospective Clinical Analysis by Yang J, Yan J, Luo H, Li L, Jiang L, Chen X, Wu L, Chai J, Xue H, Gan L, Liu Y, Chen J, Fei W, Bai Y, Zhu Q, Chen Z, Guo L, Chen Y

“…Jing Yang,1,&amp;ast; Jianna Yan,1,&amp;ast; Hao Luo,1 Liang Li,1 Long Jiang,1 Xuewen Chen,1 Ling Wu,1 Jingxiu Chai,1 Huan Xue,1 Leimeng Gan,1 Yeqiang Liu,2 Jia Chen,3 Wu Fei,2 Yun Bai,4 Quangang Zhu,5 Zhongjian Chen,5 Lehang Guo,6 Yuchong Chen1 1Department of Surgery, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 2Department of Pathology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 3Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 4Department of Central Laboratory, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 5Department of Pharmacy, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 6Department of Ultrasonography, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yuchong Chen, Department of Dermatologic Surgery Division, Shanghai Skin Disease Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China, Email 973309637@qq.comBackground: To investigate the clinical efficacy of narrow-margin modified Mohs microsurgery (mMMS) in the treatment of extramammary Paget’s disease (EMPD).Methods: A retrospective cohort review was conducted on 52 patients with EMPD who were treated at the Skin Disease Hospital of Tongji University in Shanghai between 2017 and 2023. …”
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Real-World Efficacy and Safety of Anti-PD-1 Antibody Plus Apatinib and Temozolomide for Advanced Acral Melanoma by Zhang J, Tian H, Mao L, Li C, Wei X, Gu J, Wang X, Zhou L, Lian B, Tang B, Yan X, Li S, Cui C, Chi Z, Sheng X, Guo J, Si L

“…The aim of this retrospective study was to evaluate the efficacy and safety of the triplet regimen for advanced AM in the real-world setting.Methods: The data of patients with advanced AM who received anti-PD-1 antibody plus apatinib and temozolomide at Peking University Cancer Hospital and Institute between September 2019 and December 2023 were analyzed. …”
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