The Impact of Non-Thyroidal Illness Syndromes on The Prognosis and Immune Profile in Severe Fever with Thrombocytopenia Syndrome Patients by Wu H, Mu Y, Liu Y, Zhang R, Xu Y, Zhang Y, Zhao C, Zhang W, Lin L, Chen Z

“…This study aims to evaluate the impact of NTIS on the prognosis of SFTS patients and to explore the relationship between thyroid hormones (THs) and immune cell profiles.Methods: Adult patients admitted to Yantai Qishan Hospital for SFTS from January 2023 to December 2023 with no prior history of thyroid disease were retrospectively recruited. …”
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Unveiling Key Biomarkers and Mechanisms in Septic Cardiomyopathy: A Comprehensive Transcriptome Analysis by Zhao D, Zhuang J, Wang L, Wu L, Xu W, Zhao L, Hong J, Jin W, Miao C

“…This study aimed to identify hub biomarkers in SCM and explore their potential mechanisms.Methods: We utilized the GSE53007 and GSE207363 datasets for transcriptome analysis of normal and SCM mice. …”
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Differences in the Effectiveness of Different Physical Therapy Modalities in the Treatment of Delayed-Onset Muscle Soreness: A Systematic Review and Bayesian Network Meta-Analysis by Chen J, Hu Q, Hu J, Liu S, Yin L

“…We employed a Bayesian meta-analysis to assess the efficacy and safety of physical therapy modalities (PTMs) for DOMS, aiming to provide robust, evidence-based medical insights for clinical application.Patients and Methods: We conducted a comprehensive search for randomized controlled trials (RCTs) evaluating PTMs for DOMS across databases, including CNKI, CSCD, CCD, CBM, PubMed, EMbase, Cochrane Library, and Web of Science, until October 22, 2024. …”
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Comparison of Oliceridine and Morphine in Postoperative Analgesia in Laparoscopic Total Hysterectomy, a Randomized Double-Blind Controlled Trial by Duan J, Wang X, Hou C, Yu T, Ju X, Wang S

“…Jinjuan Duan,* Xing Wang,* Chengjing Hou, Tong Yu, Xia Ju, Shengbin Wang Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Affiliated Anqing Hospital of China Pharmaceutical University, Anqing Municipal Hospital, Anqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xia Ju, Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Affiliated Anqing Hospital of China Pharmaceutical University, Anqing Municipal Hospital, No. 87 Tianzhushan East Road, Anqing, 246000, People’s Republic of China, Tel +86-13685563136, Email alcon2006@126.com Shengbin Wang, Department of Anesthesiology, Affiliated Anqing Medical Centre of Anhui Medical University, Affiliated Anqing Hospital of China Pharmaceutical University, Anqing Municipal Hospital, No. 87 Tianzhushan East Road, Anqing, 246000, People’s Republic of China, Tel +86-13955665151, Email shbw1965@126.comPurpose: Compare the analgesic efficacy and safety profiles of oliceridine and morphine in patient-controlled intravenous analgesia (PCIA) after laparoscopic total hysterectomy.Materials and Methods: This prospective, double-blind trial randomly allocated 60 patients undergoing elective laparoscopic total hysterectomy in a 1:1 ratio to receive either oliceridine (group O) or morphine (group M) via PCIA. …”
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Long-Term Surgical Outcome of Trabeculectomy with Mitomycin C: A Comparison Between Primary and Secondary Glaucoma in Thailand by Arampinyokul P, Rojananuangnit K

“…Ployroung Arampinyokul,1,2,* Kulawan Rojananuangnit1,* 1Department of Ophthalmology, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, Thailand; 2Mahidol Bumrungrak Nakhonsawan Medical Center, Nakhon Sawan, Thailand*These authors contributed equally to this workCorrespondence: Kulawan Rojananuangnit, Department of Ophthalmology, Mettapracharak (Wat Rai Khing) Hospital, 52 Moo 2 Rai Khing Sam Pran, Nakhon Pathom, 73210, Thailand, Email Kulawan@me.comPurpose: This study aimed to evaluate the long-term surgical outcomes of trabeculectomy with mitomycin C (MMC) and identify factors associated with surgical failure in Thai patients with primary and secondary glaucoma.Methods: This retrospective study included 421 eyes from 397 patients with glaucoma who underwent trabeculectomy with MMC from January 1, 2012, to December 31, 2015. …”
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The Burden of Obesity in Saudi Arabia: A Real-World Cost-of-Illness Study by Nagi MA, Almalki ZS, Thavorncharoensap M, Sangroongruangsri S, Turongkaravee S, Chaikledkaew U, Alqahtani AM, AlSharif LS, Alsubaihi IA, Alzarea AI, Alsultan MM

“…This study aimed to estimate the cost of obesity in the KSA in 2022.Methods: A prevalence-based cost-of-illness approach was used to determine the cost of obesity. …”
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Peripheral T Lymphocyte Predicts the Prognosis of Gastric Cancer Patients Undergoing Radical Gastrectomy: A Multicenter Retrospective Cohort Study by Xiao H, Zhang P, Zhang S, Xiao H, Zhou H, Liu D, Wu Z, Luo J

“…Hua Xiao,1,2,* Peng Zhang,3,* Sheng Zhang,4,* Haifan Xiao,5 Huijun Zhou,6 Dian Liu,7 Zhengchun Wu,1 Jia Luo1 1Department of Hepatobiliary and Intestinal Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 2Department of Gastroduodenal and Pancreatic Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 3Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 5Department of Cancer Prevention and Control, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 6Department of Gastroenterology and Urology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 7Department of Lamphoma and Abdominal Radiotherapy, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jia Luo, Department of Hepatobiliary and Intestinal Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha, 410013, Hunan, People’s Republic of China, Tel +86 731 89762031, Email luojia@hnca.org.cnObjective: The aim of this study was to investigate the predictive value of peripheral lymphocyte subsets for prognosis of gastric cancer (GC) patients following radical gastrectomy.Methods: Consecutive GC patients received curative resection and examined peripheral lymphocyte subsets in Hunan Cancer Hospital were enrolled as training cohort (n=231), and those from Wuhan Union Hospital and Wuhan Tongji Hospital were included as external validation cohort (n=159). …”
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ESTIMATION OF TENDENCIES IN THE HEIGHT OF THE SNOW COVERAT WEATHER STATIONS IN THE NORTHERN CAUCASUS by L. A. Kesheva

“…Materials and research methods: To obtain the results of changes in the snow cover regime from 1960/1961 to 2017/2018. …”
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S-Ketamine Reduces the Risk of Rebound Pain in Patients Following Total Knee Arthroplasty: A Randomized Controlled Trial by Li Q, Tian S, Zhang L, Chai D, Liu J, Sheng F, Jiang X, Feng W, Zhao Y, Zhu Y

“…Qun Li,1,* Shaoqi Tian,2,* Lei Zhang,1 Dongyue Chai,1 Jia Liu,1 Fang Sheng,1 Xin Jiang,3 Wei Feng,1 Yang Zhao,1 Youzhuang Zhu1 1Department of Anesthesiology, Shandong Provincial Key Medical and Health Laboratory of Anesthesia and Brain Function, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, 266000 People’s Republic of China; 2Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, 266000, People’s Republic of China; 3Phase I Clinical Trial Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province 266000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yang Zhao; Youzhuang Zhu, Department of Anesthesiology, Shandong Provincial Key Medical and Health Laboratory of Anesthesia and Brain Function, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, 266000, People’s Republic of China, Tel +860532-82919392, Email zhaoy1979@qdu.edu.cn; youzhuang_zhu@qdu.edu.cnPurpose: Investigating the effectiveness of S-ketamine in reducing rebound pain (RP) following total knee arthroplasty.Patients and Methods: This study was a randomized, double-blind, placebo-controlled trial involving 356 adult patients undergoing total knee arthroplasty. …”
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Efficacy and Safety of Lenvatinib Plus Programmed Death-1 Inhibitors with or Without Transarterial Chemoembolization in the Treatment of Unresectable Hepatocellular Carcinoma by Jin M, Jiang ZQ, Qin JH, Qin HX, Jiang KW, Ya HX, Gu J, Gui MR, Li YH, Xu LK, Fu HX, Xiao XH, Li SQ

“…This study aimed to evaluate the clinical benefits and tolerability of TACE added to a combination of lenvatinib and programmed death-1 (PD-1) inhibitor in patients with unresectable HCC (uHCC).Patients and Methods: We conducted a retrospective cohort study involving 144 patients with uHCC treated between August 2020 and August 2023. …”
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Effects of Oltipraz on the Glycolipid Metabolism and the Nrf2/HO-1 Pathway in Type 2 Diabetic Mice by Luo Y, Sun S, Zhang Y, Liu S, Zeng H, Li JE, Huang J, Fang L, Yang S, Yu P, Liu J

“…Hence, a comprehensive understanding of how oltipraz ameliorates diabetes, particularly inflammation and oxidative stress, is imperative.Methods: The negative control (NC), T2DM model (T2DM), and T2DM models treated with oltipraz (OLTI) and metformin (MET) were constructed. …”
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Long-Term Benefits of N-Butylphthalide in Preventing Ischemic Stroke Recurrence: A 12-Month Prospective Study by Liu W, Shao Y, Liu J, Hao J, Lu Y, Yang L, Wang J, Ning X

“…Wei Liu,1,* Yingzhe Shao,1,* Jie Liu,2,* Juan Hao,1 Yuting Lu,3 Li Yang,1 Jinghua Wang,1,4,5 Xianjia Ning1,4,5 1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, People’s Republic of China; 3School of Basic medical Sciences, Tianjin Medical University, Tianjin, 300070, People’s Republic of China; 4Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, 300052, People’s Republic of China; 5Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, 300052, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianjia Ning; Jinghua Wang, Department of Neurology, Tianjin Medical University General Hospital, Laboratory of Epidemiology, Tianjin Neurological Institute &Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, 154 Anshan Road, Heping District, Tianjin, 300052, People’s Republic of China, Tel +86-22-60817505 ; +86-22-60817504, Fax +86-22-60817448, Email xning@tmu.edu.cn; jwang3@tmu.edu.cnPurpose: This study evaluated the effects of 12 months of NBP treatment on stroke recurrence and examined the influence of age and gender on its efficacy.Methods: A prospective cohort of 1109 patients with non-cardioembolic ischemic stroke (IS) within six months was divided into NBP (n = 538) and control (n = 571) groups. …”
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The Suppression of Signal Transducer and Activator of Transcription-3 in A549 human Lung Carcinoma Cells Induced by Marine Sponge Callyspongia aerizusa by Hadisaputri YE, Nurhaniefah AA, Mutakin M, Hendriani R, Rezano A, Sopyan I, Yusnaini Y, Asikin Y, Abdulah R

“…Several reviews also validated the upregulation of pro-apoptotic molecules and the inhibition of anti-apoptotic molecules linked to the caspase-dependent signaling pathway.Purpose: The objective of this research was to extend the understanding of the effects of C. aerizusa extract on A549 lung carcinoma, examining its influence on various signaling pathways, malignancy, migration, and invasion.Materials and Methods: PCR was used to measure mRNA expression, targeting PTEN, Akt, mTOR, STAT-3, IL-6, VEGF, and HIF1α. …”
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Resting Heart Rate Mediates the Association Between Circulating Neutrophil Count and Arterial Stiffness Progression: The Kailuan Study by Wu Z, Wu D, Chen S, Xu S, Zhang S, Wu S

“…Zhaogui Wu,1,* Dan Wu,2,3,* Shuohua Chen,4 Sichi Xu,5,6 Shunming Zhang,7 Shouling Wu4 1Department of Cardiology, Xiangyang No. 1 People’s Hospital, Hubei University of Medicine, Xiangyang, Hubei, 441000, People’s Republic of China; 2Department of Pediatrics, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People’s Republic of China; 3Centre for Precision Health, Edith Cowan University School of Medical and Health Sciences, Joondalup, WA, Australia; 4Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei, 063001, People’s Republic of China; 5Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, People’s Republic of China; 6Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, People’s Republic of China; 7School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shouling Wu, Department of Cardiology, Kailuan General Hospital, No. 57, Xinhuadong Street, Lubei District, Tangshan, Hebei, 063001, People’s Republic of China, Tel +86 13363283666, Email drwusl@163.com Shunming Zhang, School of Public Health, Xi’an Jiaotong University Health Science Center, No. 76, Yanta West Road, Xi’an, Shaanxi, 710061, People’s Republic of China, Tel +86 19502920539, Email zhangshunming@xjtu.edu.cnObjective: This study aimed to longitudinally investigate the association between circulating neutrophil count and the progression of arterial stiffness and to ascertain whether resting heart rate (RHR) mediates this association.Methods: The current study included 56,760 participants with brachial-ankle pulse wave velocity (baPWV) measurements from a real-life, prospective cohort in China. …”
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Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition by Jing-Jing Liu, Xiao-qi Zhou, Jia-Lin Zhou, Li-Jun Tong, Ling-Xiang Hu, Xiang Liu, Li-Mei Hu, Chang-Xiao Zhou, Qi Dai

“…Groups A and B received equal volumes of normal saline. Serum and hepatic tissues were collected for analysis. …”
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Risks and Benefits of Nalmefene in the Treatment of Adult Alcohol Dependence: A Systematic Literature Review and Meta-Analysis of Published and Unpublished Double-Blind Randomized... by Clément Palpacuer, Bruno Laviolle, Rémy Boussageon, Jean Michel Reymann, Eric Bellissant, Florian Naudet

“…In sensitivity analyses, outcomes for participants who were lost to follow-up were included using baseline observation carried forward (BOCF); for binary measures, patients lost to follow-up were considered equal to failures (i.e., non-assessed patients were recorded as not having responded in both groups). …”
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Effects of an Emergency-Based FASE Strategy on Treating Geriatric Patients with Femoral Neck Fracture: A Retrospective Propensity Score-Matched Study by Zhou J, Shi L, Tian C, Gao Y, Wang J, Mao J, Li Y, Fan W, Chen X, Zhang C, Xie T, Rui Y

“…Jun Zhou,1,2,* Liu Shi,1,2,* Chuwei Tian,1,2 Yucheng Gao,1,2 Jinyu Wang,2,3 Jin Mao,2,4 Yan Li,2,4 Wenbin Fan,1,2 Xiangxu Chen,1,2 Cheng Zhang,1,2 Tian Xie,1,2 Yunfeng Rui1,2,* 1Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, People’s Republic of China; 2Multidisciplinary Team for Geriatric Hip Fracture Comprehensive Management, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, People’s Republic of China; 3Department of Rehabilitation, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, People’s Republic of China; 4Department of Emergency, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunfeng Rui, Department of Orthopaedics, Zhongda Hospital, School of Medicine, Southeast University, NO. 87 Ding Jia Qiao, Nanjing, Jiangsu, 210009, People’s Republic of China, Tel +86 13705182577, Email ruiyunfeng@126.comIntroduction: This study aims to assess the impacts of the Fast Access to Surgery in Emergency (FASE) strategy on (1) the workflow of multidisciplinary team (MDT) during hospitalization; (2) the clinical outcomes of geriatric femoral neck fracture (FNF) patients.Methods: A retrospective study was conducted in a single trauma center to evaluate the clinical data of geriatric FNF patients admitted through emergency from July 2017 to June 2022. …”
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Development and Psychometric Evaluation of an Instrument to Assess Physical Activity Participation Behavior Among Chinese Patients with Chronic Obstructive Pulmonary Disease by Liao Y, Wang H, Zhan Y, Liu Y, Wang W, Ke H, Lan F, Zhi Q, Li W, Yu J

“…Yuanyu Liao,1,2,* Huan Wang,3,* Yuxin Zhan,3 Yunfang Liu,4 Weiwei Wang,5 Hui Ke,6 Fenfen Lan,2 Qiongge Zhi,2 Wang Li,2 Jiaohua Yu1 1Department of Nursing, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 2School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 3Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 4Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 5Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 6Department of Wound Care Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiaohua Yu, Department of Nursing, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei, 430022, People’s Republic of China, Email yujiaohua2008@126.comPurpose: This study aimed to develop and evaluate a psychometrically reliable tool specifically designed to assess physical activity participation behavior in COPD patients in China.Patients and Methods: Using the Motivation-Opportunity-Ability (MOA) model as a framework, a scale was developed and evaluated through literature and guideline reviews, qualitative research, interdisciplinary expert consultations (n=21), and a pilot trial (n=50). …”
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Reasons for Hospital Admissions in Chronic Hypercapnic COPD Patients on Long-Term Nocturnal Noninvasive Ventilation – A Prospective Observational Study by Koschel S, Stanzel SB, Kroppen D, Duiverman M, Wollsching-Strobel M, Majorski D, Berger MP, Schumacher F, Holle JF, Windisch W, Zimmermann M

“…Simon Koschel,1,2,* Sarah Bettina Stanzel,1,2,* Doreen Kroppen,1,2 Marieke Duiverman,3,4 Maximilian Wollsching-Strobel,1,2 Daniel Majorski,1,2 Melanie Patricia Berger,1,2 Falk Schumacher,2,5 Johannes Fabian Holle,2,6 Wolfram Windisch,1,2 Maximilian Zimmermann1,2 1Cologne Merheim Hospital, Department of Pneumology, Kliniken der Stadt Köln gGmbH, Cologne, Germany; 2Witten/Herdecke University, Witten, Germany; 3Department of Pulmonary Diseases and Home Mechanical Ventilation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; 4Groningen Research Institute of Asthma and COPD (GRIAC), University of Groningen, Groningen, The Netherlands; 5Department of Rheumatology, Krankenhaus Porz Am Rhein, Cologne, Germany; 6Cologne Merheim Hospital, Department of Neurology, Kliniken der Stadt Köln gGmbH, Cologne, Germany*These authors contributed equally to this workCorrespondence: Maximilian Zimmermann, Department of Pneumology, Cologne Merheim Hospital; Kliniken der Stadt Köln gGmbH, Witten/Herdecke University, Faculty of Health/School of Medicine, Ostmerheimer Strasse 200, Köln, D-51109, Germany, Tel +49221890713468, Fax +4922189073666, Email zimmermannma@kliniken-koeln.deBackground: Non-invasive ventilation (NIV) is vital for managing chronic hypercapnic respiratory failure in COPD patients, yet the impact of handling issues like mask compliance triggering hospitalisations is often underestimated.Methods: A prospective, monocentric observational study was performed in COPD patients hospitalized for acute exacerbation with established home NIV therapy. …”
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Novel Antigen-Presenting Cell-Targeted Nanoparticles Enhance Split Vaccine Immunity Through Microneedles Inoculation by Xiu X, Fu H, Zhang R, Ma S, Guo P, Li Z, Zhu Y, Ma F

“…We designed and synthesized NPs that could form complexes with split H1N1 antigens, and evaluated the immunogenicity after loading them into dissolvable microneedle arrays (dMAs).Methods: Man-N-HACC was synthesized by conjugating mannose moieties to N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-HACC), followed by cross-linking with tripolyphosphate to form Man-N-HACC NPs. …”
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